PT1387842E - 2-aminobenzoxazolsulfonamidas inibidoras de largo espectro da protease hiv - Google Patents

2-aminobenzoxazolsulfonamidas inibidoras de largo espectro da protease hiv Download PDF

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Publication number
PT1387842E
PT1387842E PT02735354T PT02735354T PT1387842E PT 1387842 E PT1387842 E PT 1387842E PT 02735354 T PT02735354 T PT 02735354T PT 02735354 T PT02735354 T PT 02735354T PT 1387842 E PT1387842 E PT 1387842E
Authority
PT
Portugal
Prior art keywords
broadspectrum
amino
protease inhibitors
hiv protease
benzoxazole sulfonamide
Prior art date
Application number
PT02735354T
Other languages
English (en)
Inventor
Herman Augustinus De Kock
Marie-Pierre T M M G D Bethune
Dominique Louis Nest Surleraux
Sandrine Marie Hele Vendeville
Wim Gaston Verschueren
Abdellah Tahri
Original Assignee
Tibotec Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd
Publication of PT1387842E publication Critical patent/PT1387842E/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
PT02735354T 2001-05-11 2002-05-10 2-aminobenzoxazolsulfonamidas inibidoras de largo espectro da protease hiv PT1387842E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP01201732 2001-05-11

Publications (1)

Publication Number Publication Date
PT1387842E true PT1387842E (pt) 2009-07-20

Family

ID=8180286

Family Applications (1)

Application Number Title Priority Date Filing Date
PT02735354T PT1387842E (pt) 2001-05-11 2002-05-10 2-aminobenzoxazolsulfonamidas inibidoras de largo espectro da protease hiv

Country Status (32)

Country Link
US (2) US7622490B2 (pt)
EP (1) EP1387842B1 (pt)
JP (1) JP4467889B2 (pt)
KR (1) KR100878853B1 (pt)
CN (1) CN100549007C (pt)
AP (1) AP1652A (pt)
AR (1) AR035970A1 (pt)
AT (1) ATE429431T1 (pt)
AU (1) AU2002310818B2 (pt)
BG (1) BG66350B1 (pt)
BR (1) BR0209594A (pt)
CA (1) CA2444895C (pt)
CY (1) CY1109247T1 (pt)
CZ (1) CZ304524B6 (pt)
DE (1) DE60232067D1 (pt)
DK (1) DK1387842T3 (pt)
EA (1) EA009590B1 (pt)
EE (1) EE05307B1 (pt)
ES (1) ES2325809T3 (pt)
HK (1) HK1062912A1 (pt)
HR (1) HRP20031026B1 (pt)
HU (1) HUP0400438A3 (pt)
IL (1) IL158093A0 (pt)
MX (1) MXPA03010258A (pt)
NO (1) NO326883B1 (pt)
NZ (1) NZ529250A (pt)
OA (1) OA13134A (pt)
PL (1) PL209029B1 (pt)
PT (1) PT1387842E (pt)
SK (1) SK287952B6 (pt)
WO (1) WO2002092595A1 (pt)
ZA (1) ZA200307799B (pt)

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JP5767429B2 (ja) 1999-11-12 2015-08-19 アッヴィ・インコーポレイテッド 固体分散剤中の結晶化阻害剤
DE10026698A1 (de) 2000-05-30 2001-12-06 Basf Ag Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung
WO2003057173A2 (en) 2002-01-07 2003-07-17 Sequoia Pharmaceuticals Broad spectrum inhibitors
US7157489B2 (en) 2002-03-12 2007-01-02 The Board Of Trustees Of The University Of Illinois HIV protease inhibitors
US8025899B2 (en) 2003-08-28 2011-09-27 Abbott Laboratories Solid pharmaceutical dosage form
CA2537877C (en) * 2003-09-30 2015-03-17 Tibotec Pharmaceuticals Ltd. Methods for the preparation of benzoxazole sulfonamide compounds and intermediates thereof
US20050131042A1 (en) * 2003-12-11 2005-06-16 Flentge Charles A. HIV protease inhibiting compounds
US8193227B2 (en) 2003-12-11 2012-06-05 Abbott Laboratories HIV protease inhibiting compounds
US7772411B2 (en) 2003-12-23 2010-08-10 Tibotec Pharmaceuticals Ltd. Process for the preparation of (3R,3aS,6aR)-hexahydrofuro [2,3-b] furan-3-yl (1S,2R)-3[[(4-aminophenyl) sulfonyl] (isobutyl) amino]-1-benzyl-2-hydroxypropylcarbamate
KR101192859B1 (ko) 2003-12-23 2012-10-19 얀센 알 앤드 디 아일랜드 （3ｒ,3ａｓ,6ａｒ）-헥사하이드로푸로〔2,3-ｂ〕푸란-3-일（1ｓ,2ｒ）-3-〔〔（4-아미노페닐）설포닐〕（이소부틸）아미노〕-1-벤질-2-하이드록시프로필카바메이트의 제조방법
AU2005244121B2 (en) * 2004-05-07 2012-01-19 Sequoia Pharmaceuticals, Inc. Resistance-repellent retroviral protease inhibitors
MX2007010378A (es) 2005-02-25 2007-09-25 Tibotec Pharm Ltd Sintesis del precursor inhibidor de la proteasa.
AR053845A1 (es) * 2005-04-15 2007-05-23 Tibotec Pharm Ltd 5-tiazolilmetil[(1s,2r)-3-[[(2-amino-6-benzoxazolil)sulfonil)](2-metilpropil)amino]-2-hidroxi-1-(fenilmetil)propil]carbamato como mejorador de farmacos metabolizados por el citocromo p450
US20120220520A1 (en) * 2006-10-17 2012-08-30 Van T Klooster Gerben Albert Eleutherius Bioavailable combinations for hcv treatment
WO2014194519A1 (en) 2013-06-07 2014-12-11 Merck Sharp & Dohme Corp. Imidazole derivatives and methods of use thereof for improving pharmacokinetics of drug

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SE8204879D0 (sv) 1982-08-26 1982-08-26 Haessle Ab Novel chemical intermediates
ATE141635T1 (de) 1990-03-09 1996-09-15 Milliken Res Corp Organische materialien, die sulfonamidogebundene poly(oxyalkylen)gruppen tragen und ihre herstellung
US5145684A (en) 1991-01-25 1992-09-08 Sterling Drug Inc. Surface modified drug nanoparticles
CA2142998C (en) * 1992-08-25 2008-01-29 Michael L. Vazquez N-(alkanoylamino-2-hydroxypropyl)-sulfonamides useful as retroviral protease inhibitors
PH30929A (en) 1992-09-03 1997-12-23 Janssen Pharmaceutica Nv Beads having a core coated with an antifungal and a polymer.
EP0715618B1 (en) * 1993-08-24 1998-12-16 G.D. Searle & Co. Hydroxyethylamino sulphonamides useful as retroviral protease inhibitors
JP3732508B2 (ja) 1993-10-01 2006-01-05 アストラ・アクチエボラーグ 粉末状薬剤の製造方法
AU4700896A (en) 1995-01-20 1996-08-07 G.D. Searle & Co. Bis-sulfonamide hydroxyethylamino retroviral protease inhibitors
US5756533A (en) * 1995-03-10 1998-05-26 G.D. Searle & Co. Amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
RU2174519C2 (ru) 1995-03-10 2001-10-10 Джи. Ди. Сирл Энд Ко. Гидроксиэтиламино сульфонамиды гетероциклокарбонил аминокислоты, ингибирующие ретровирусную протеазу
US5705500A (en) * 1995-03-10 1998-01-06 G.D. Searle & Co. Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
US6150556A (en) * 1995-03-10 2000-11-21 G. D. Dearle & Co. Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors
AU7722296A (en) * 1995-11-15 1997-06-05 G.D. Searle & Co. Substituted sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
EP0904060B1 (en) 1996-05-20 2003-12-10 Janssen Pharmaceutica N.V. Antifungal compositions with improved bioavailability
EE03904B1 (et) 1997-03-26 2002-12-16 Janssen Pharmaceutica N.V. Graanul, farmatseutiline doseerimisvorm, graanulite valmistamismeetod ja ravimiga kaetud graanulid
GB9717849D0 (en) 1997-08-23 1997-10-29 Seal Sands Chemicals Limited Preparation of pyridene derivatives
AU2012199A (en) 1997-12-24 1999-07-19 Vertex Pharmaceuticals Incorporated Prodrugs of aspartyl protease inhibitors
ID25551A (id) 1997-12-24 2000-10-12 Vertex Pharma Bahan baku obat penghambat protease aspartil
US6436989B1 (en) 1997-12-24 2002-08-20 Vertex Pharmaceuticals, Incorporated Prodrugs of aspartyl protease inhibitors
AU2010299A (en) 1997-12-24 1999-07-19 Vertex Pharmaceuticals Incorporated Prodrugs os aspartyl protease inhibitors
AU4828199A (en) * 1998-06-23 2000-01-10 Board Of Trustees Of The University Of Illinois, The Multi-drug resistant retroviral protease inhibitors and associated methods
ATE500823T1 (de) 1998-06-23 2011-03-15 Us Of America Represented By The Secretary Dept Of Health And Human Services Arzneimittel zur behandlung von hiv-infizierten säugetieren
SK288232B6 (sk) * 2001-04-09 2014-11-04 Tibotec Pharmaceuticals Ltd. 2-(substituovaný amino)benzoxazolsulfónamidový derivát, jeho aplikácie ako liečiva, farmaceutická kompozícia s jeho obsahom a spôsob in vitro inhibície retrovírusovej replikácie

Also Published As

Publication number Publication date
EA009590B1 (ru) 2008-02-28
DK1387842T3 (da) 2009-08-10
NO326883B1 (no) 2009-03-09
CA2444895C (en) 2011-02-15
OA13134A (en) 2006-12-13
BG108309A (bg) 2004-12-30
NZ529250A (en) 2005-05-27
ZA200307799B (en) 2005-03-30
PL209029B1 (pl) 2011-07-29
CY1109247T1 (el) 2014-07-02
HUP0400438A3 (en) 2007-08-28
CA2444895A1 (en) 2002-11-21
BG66350B1 (bg) 2013-08-30
CN1507446A (zh) 2004-06-23
KR20040022417A (ko) 2004-03-12
EP1387842A1 (en) 2004-02-11
WO2002092595A1 (en) 2002-11-21
KR100878853B1 (ko) 2009-01-15
ES2325809T3 (es) 2009-09-18
EE200300547A (et) 2004-02-16
AR035970A1 (es) 2004-07-28
JP2004534757A (ja) 2004-11-18
EP1387842B1 (en) 2009-04-22
HRP20031026B1 (en) 2012-07-31
AP2003002904A0 (en) 2003-12-31
US7622490B2 (en) 2009-11-24
CZ20033290A3 (cs) 2004-05-12
CZ304524B6 (cs) 2014-06-18
EE05307B1 (et) 2010-06-15
US7863306B2 (en) 2011-01-04
DE60232067D1 (de) 2009-06-04
JP4467889B2 (ja) 2010-05-26
US20040106661A1 (en) 2004-06-03
BR0209594A (pt) 2004-03-30
PL366780A1 (en) 2005-02-07
MXPA03010258A (es) 2005-03-07
ATE429431T1 (de) 2009-05-15
NO20034988D0 (no) 2003-11-10
AP1652A (en) 2006-08-11
HK1062912A1 (en) 2004-12-03
SK14902003A3 (sk) 2004-07-07
AU2002310818B2 (en) 2007-12-13
US20100029632A1 (en) 2010-02-04
EA200301234A1 (ru) 2004-04-29
HUP0400438A2 (hu) 2004-08-30
CN100549007C (zh) 2009-10-14
IL158093A0 (en) 2004-03-28
SK287952B6 (sk) 2012-06-04
HRP20031026A2 (en) 2005-10-31

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