ECSP15007358A - Pirrol carboxamidas fluorometilo sustituidas - Google Patents

Pirrol carboxamidas fluorometilo sustituidas

Info

Publication number
ECSP15007358A
ECSP15007358A ECIEPI20157358A ECPI201507358A ECSP15007358A EC SP15007358 A ECSP15007358 A EC SP15007358A EC IEPI20157358 A ECIEPI20157358 A EC IEPI20157358A EC PI201507358 A ECPI201507358 A EC PI201507358A EC SP15007358 A ECSP15007358 A EC SP15007358A
Authority
EC
Ecuador
Prior art keywords
pirrol
fluoromethyl
carboxamides substituted
carboxamides
compounds
Prior art date
Application number
ECIEPI20157358A
Other languages
English (en)
Inventor
Melanie Reich
Kathy Sutton
Philip Skone
Nils Damann
Marc Rogers
Stefan Schunk
Henning Steinhagen
Robert Kirby
Richard Hamlyn
Original Assignee
Collecte Localisation Satellites
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Collecte Localisation Satellites filed Critical Collecte Localisation Satellites
Publication of ECSP15007358A publication Critical patent/ECSP15007358A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/323—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to the ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

La invención se refiere a las carboxamidas de pirrol que tienen una fracción de fluorometilo como bloqueadores de canales de calcio activados por voltaje, a composiciones farmacéuticas que contienen estos compuestos y al uso de estos compuestos para el tratamiento y/o profilaxis del dolor y otras enfermedades y/o trastornos.
ECIEPI20157358A 2012-08-29 2015-02-27 Pirrol carboxamidas fluorometilo sustituidas ECSP15007358A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP12006120 2012-08-29

Publications (1)

Publication Number Publication Date
ECSP15007358A true ECSP15007358A (es) 2015-12-31

Family

ID=46851247

Family Applications (1)

Application Number Title Priority Date Filing Date
ECIEPI20157358A ECSP15007358A (es) 2012-08-29 2015-02-27 Pirrol carboxamidas fluorometilo sustituidas

Country Status (28)

Country Link
US (1) US9302988B2 (es)
EP (1) EP2906534B1 (es)
JP (1) JP6114392B2 (es)
KR (1) KR20150046321A (es)
CN (1) CN104755459A (es)
AR (1) AR092279A1 (es)
AU (1) AU2013307645B2 (es)
BR (1) BR112015004306A2 (es)
CA (1) CA2883242A1 (es)
CL (1) CL2015000460A1 (es)
CY (1) CY1118542T1 (es)
DK (1) DK2906534T3 (es)
EA (1) EA027640B1 (es)
EC (1) ECSP15007358A (es)
ES (1) ES2618520T3 (es)
HK (1) HK1212685A1 (es)
HR (1) HRP20170338T1 (es)
HU (1) HUE032691T2 (es)
IL (1) IL237393A (es)
LT (1) LT2906534T (es)
MX (1) MX2015002357A (es)
PE (1) PE20150403A1 (es)
PL (1) PL2906534T3 (es)
PT (1) PT2906534T (es)
RS (1) RS55702B1 (es)
SI (1) SI2906534T1 (es)
TW (1) TW201416348A (es)
WO (1) WO2014032801A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105073728A (zh) 2013-03-15 2015-11-18 全球血液疗法股份有限公司 化合物及其用于调节血红蛋白的用途
EA201992707A1 (ru) 2013-11-18 2020-06-30 Глобал Блад Терапьютикс, Инк. Соединения и их применения для модуляции гемоглобина
ES2660760T3 (es) * 2013-12-19 2018-03-26 Grünenthal GmbH Pirrolocarboxamidas fluorometil-sustituidas como bloqueantes del canal de Ca CaV2.2
EP3083612A1 (en) 2013-12-19 2016-10-26 Grünenthal GmbH Fluoromethyl-substituted pyrrole carboxamides as cav2.2 calcium channel blockers
JP2016540823A (ja) 2013-12-19 2016-12-28 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング フルオロ置換ピロールカルボキサミドｉｖ
TW201718557A (zh) * 2015-10-08 2017-06-01 歌林達有限公司 經吡唑基取代之四氫吡喃基碸
TW201726128A (zh) * 2015-10-08 2017-08-01 歌林達有限公司 經吡唑基取代之四氫哌喃基碸
TWI731540B (zh) * 2019-01-04 2021-06-21 大陸商蘇州亞盛藥業有限公司 製備磺胺類藥物的方法
MX2021008364A (es) * 2019-01-11 2021-08-05 Gruenenthal Gmbh Amidas de pirrolidina iii sustituidas.

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19963174A1 (de) * 1999-12-27 2001-07-12 Gruenenthal Gmbh Substituierte Pyrrol-Mannichbasen
WO2003057669A1 (fr) * 2001-12-28 2003-07-17 Takeda Chemical Industries, Ltd. Antagonistes du recepteur androgene
EP1546183A4 (en) * 2002-09-23 2008-06-18 Du Pont ISOLATION AND USE OF RYANODINE RECEPTORS
DE10261130A1 (de) * 2002-12-20 2004-07-01 Grünenthal GmbH Arzneimittel enthaltend substituierte 2,5-Diaminomethyl-1H-pyrrole
DE102006027229A1 (de) * 2006-06-09 2007-12-20 Grünenthal GmbH 1,3-Disubstituierte 4-Methyl-1H-pyrrol-2-carbonsäureamide und ihre Verwendung zur Herstellung von Arzneimitteln
US9115132B2 (en) * 2010-07-09 2015-08-25 Convergence Pharmaceuticals Limited Tetrazole compounds as calcium channel blockers

Also Published As

Publication number Publication date
CA2883242A1 (en) 2014-03-06
PT2906534T (pt) 2017-03-08
CY1118542T1 (el) 2017-07-12
ES2618520T3 (es) 2017-06-21
KR20150046321A (ko) 2015-04-29
SI2906534T1 (sl) 2017-03-31
EA027640B1 (ru) 2017-08-31
US9302988B2 (en) 2016-04-05
JP6114392B2 (ja) 2017-04-12
PE20150403A1 (es) 2015-04-16
JP2015526488A (ja) 2015-09-10
IL237393A (en) 2017-02-28
CL2015000460A1 (es) 2015-05-29
TW201416348A (zh) 2014-05-01
HUE032691T2 (hu) 2017-10-30
EA201500270A8 (ru) 2016-01-29
DK2906534T3 (en) 2017-01-23
PL2906534T3 (pl) 2017-06-30
LT2906534T (lt) 2017-02-27
AR092279A1 (es) 2015-04-08
US20140066426A1 (en) 2014-03-06
HRP20170338T1 (hr) 2017-04-21
AU2013307645A1 (en) 2015-04-16
AU2013307645B2 (en) 2017-03-30
CN104755459A (zh) 2015-07-01
WO2014032801A1 (en) 2014-03-06
MX2015002357A (es) 2015-06-05
IL237393A0 (en) 2015-04-30
BR112015004306A2 (pt) 2017-07-04
EA201500270A1 (ru) 2015-07-30
HK1212685A1 (zh) 2016-06-17
EP2906534A1 (en) 2015-08-19
EP2906534B1 (en) 2016-12-07
RS55702B1 (sr) 2017-07-31

Similar Documents

Publication Publication Date Title
ECSP15007358A (es) Pirrol carboxamidas fluorometilo sustituidas
ECSP13012573A (es) 6-amino-nicotinamidas sustituidas como moduladores de KCNQ2/3
CR20150067A (es) Pirazoles sustituidos como bloqueadores del canal de calcio tipo n
GT201400111A (es) Triazolopiridinas sustituidas
DOP2015000245A (es) Derivados de 3-acetilamino-1 (fenil-heteroaril-aminocarbonil o fenil-heteroaril-carbonilamino) benceno para el tratamiento de desordenes hiperproliferativos
ECSP14017269A (es) Compuestos para tratar la atrofia muscular espinal
CL2016002615A1 (es) Heterociclil-sulfonas sustituidas con heteroarilo y su uso contra el dolor, accidente cerebrovascular, transtornos anímicos, epilepsia, esquizofrenia y trastornos neurodegenerativos.
PA8780201A1 (es) Derivados de pirasol sustituidos con heteroaril utiles para tratar trastornos hiperproliferativos y enfermedades asociadas con angiogénesis
UY35040A (es) Pirrolopirimidinilamino-benzotiazolonas sustituidas
ECSP12012270A (es) Compuestos de pirazol como inhibidores del receptor sigma
DOP2016000253A (es) Nuevos compuestos
ECSP13012453A (es) 2-oxi-quinolina-3-carboxamidas sustituidas como moduladores KCNQ2/3
HN2012000023A (es) Compuestos y composiciones para el tratamiento de enfermedades parasitarias
UY32937A (es) Compuestos y composiciones como moduladores de la actividad de gpr119
CR20150070A (es) Pirrolopirazoles como bloqueadores del canal de calcio tipo n
NI201700078A (es) Pirazolpiridinaminas
BR112018007006A2 (pt) tetra-hidropiranilsulfonas substituídas por pirazolil
CR20160016A (es) Pirazolpiridinas sustituidas
UY35848A (es) Tienopirimidinas
DOP2016000251A (es) Inhibidores de las vías de señalización de wnt
BR112018007004A2 (pt) tetra-hidropiranilsulfonas substituídas por pirazolil
BR112016012552A8 (pt) derivado de cromona como um antagonista do receptor d3 de dopamina, seu uso e sua composição farmacêutica
ECSP13012460A (es) 2-oxo- y 2-tioxo-dihidroquinolina-3-carboxamidas sustituidos como moduladores KCNQ2/3
MX2016007955A (es) Pirrol carboxamidas iii fluorometil-sustituidas.
BR112016023926A2 (pt) heterociclil sulfonas substituídas por aril