CR20150070A - Pirrolopirazoles como bloqueadores del canal de calcio tipo n - Google Patents

Pirrolopirazoles como bloqueadores del canal de calcio tipo n

Info

Publication number
CR20150070A
CR20150070A CR20150070A CR20150070A CR20150070A CR 20150070 A CR20150070 A CR 20150070A CR 20150070 A CR20150070 A CR 20150070A CR 20150070 A CR20150070 A CR 20150070A CR 20150070 A CR20150070 A CR 20150070A
Authority
CR
Costa Rica
Prior art keywords
pirrolopirazoles
blockers
channel type
calcium channel
syndromes
Prior art date
Application number
CR20150070A
Other languages
English (en)
Inventor
Michael P Winters
Zhihua Sui
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49170857&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CR20150070(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of CR20150070A publication Critical patent/CR20150070A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se describen compuestos, composiciones y métodos para el tratamiento de varias enfermedades, síndromes, afecciones y trastornos, que incluyen el dolor.
CR20150070A 2012-08-16 2015-02-10 Pirrolopirazoles como bloqueadores del canal de calcio tipo n CR20150070A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261683780P 2012-08-16 2012-08-16
PCT/US2013/055275 WO2014028805A1 (en) 2012-08-16 2013-08-16 Pyrrolopyrazoles as n-type calcium channel blockers

Publications (1)

Publication Number Publication Date
CR20150070A true CR20150070A (es) 2015-05-18

Family

ID=49170857

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20150070A CR20150070A (es) 2012-08-16 2015-02-10 Pirrolopirazoles como bloqueadores del canal de calcio tipo n

Country Status (19)

Country Link
US (1) US8846949B2 (es)
EP (1) EP2885304B8 (es)
JP (1) JP6250674B2 (es)
KR (1) KR20150042271A (es)
CN (1) CN104936960B (es)
AU (1) AU2013302473B2 (es)
BR (1) BR112015003359A2 (es)
CA (1) CA2882127A1 (es)
CL (1) CL2015000359A1 (es)
CR (1) CR20150070A (es)
EA (1) EA201590379A1 (es)
ES (1) ES2607839T3 (es)
IL (1) IL237192A0 (es)
IN (1) IN2015DN01230A (es)
MX (1) MX2015002039A (es)
PE (1) PE20151139A1 (es)
PH (1) PH12015500310A1 (es)
SG (1) SG11201501133WA (es)
WO (1) WO2014028805A1 (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9974775B2 (en) 2013-08-16 2018-05-22 Janssen Pharmaceutica Nv Substituted imidazoles as N-type calcium channel blockers

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA201590381A1 (ru) 2012-08-16 2015-07-30 Янссен Фармацевтика Нв Замещенные пиразолы, используемые в качестве блокаторов кальциевых каналов n-типа
US10683294B2 (en) 2017-05-31 2020-06-16 Chemocentryx, Inc. 5-5 fused rings as C5a inhibitors
US10562896B2 (en) 2017-05-31 2020-02-18 Chemocentryx, Inc. 6-5 fused rings as C5a inhibitors
US10759807B2 (en) * 2017-12-22 2020-09-01 Chemocentryx, Inc. Diaryl substituted 5,5-fused ring compounds as C5aR inhibitors
BR112020012270A2 (pt) 2017-12-22 2020-11-24 Chemocentryx, Inc. compostos de anel 6,5-fundido substituído por diarila como inibidores de c5ar
MX2020010390A (es) 2018-04-02 2021-01-15 Chemocentryx Inc Profarmacos de antagonistas de c5ar biciclicos fusionados.
CN112300169B (zh) * 2019-07-26 2022-03-04 上海美迪西生物医药股份有限公司 吡咯并吡唑类衍生物、其制备方法及其在医药上的应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1287174B1 (it) * 1996-11-15 1998-08-04 Angelini Ricerche Spa Diaril-ciclometilenpirazoli farmacologicamente attivi,procedimento per prepararli e composizioni farmaceutiche che li contengono
JP2006522130A (ja) * 2003-04-03 2006-09-28 メルク　エンド　カムパニー　インコーポレーテッド ナトリウムチャンネル遮断薬としてのビアリール置換ピラゾール
US7145012B2 (en) * 2003-04-23 2006-12-05 Pfizer Inc. Cannabinoid receptor ligands and uses thereof
BRPI0414541B8 (pt) * 2003-09-17 2021-05-25 Janssen Pharmaceutica Nv compostos heterocíclicos fundidos tendo atividade de modulação de receptor de serotonina, método de preparação de compostos intermediários
FR2864958B1 (fr) * 2004-01-12 2006-02-24 Sanofi Synthelabo Derive de n-[(1,5-diphenyl-1h-pyrazol-3-yl)methyl] sulfonamide, leur preparation et leur application en therapeutique.
BRPI0508594A (pt) * 2004-03-08 2007-08-21 Wyeth Corp moduladores de canal de ìon
CA2558224A1 (en) * 2004-03-08 2005-09-22 Wyeth Ion channel modulators

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9974775B2 (en) 2013-08-16 2018-05-22 Janssen Pharmaceutica Nv Substituted imidazoles as N-type calcium channel blockers

Also Published As

Publication number Publication date
PE20151139A1 (es) 2015-08-07
PH12015500310A1 (en) 2015-04-20
SG11201501133WA (en) 2015-04-29
BR112015003359A2 (pt) 2017-07-04
AU2013302473A1 (en) 2015-02-26
EP2885304B1 (en) 2016-09-21
CN104936960B (zh) 2016-12-28
JP2015524853A (ja) 2015-08-27
US8846949B2 (en) 2014-09-30
US20140051688A1 (en) 2014-02-20
WO2014028805A1 (en) 2014-02-20
MX2015002039A (es) 2016-01-22
AU2013302473B2 (en) 2017-08-10
CL2015000359A1 (es) 2015-04-24
CN104936960A (zh) 2015-09-23
IL237192A0 (en) 2015-04-30
EP2885304A1 (en) 2015-06-24
EP2885304B8 (en) 2016-12-07
EA201590379A1 (ru) 2015-06-30
JP6250674B2 (ja) 2017-12-20
ES2607839T3 (es) 2017-04-04
CA2882127A1 (en) 2014-02-20
KR20150042271A (ko) 2015-04-20
IN2015DN01230A (en) 2015-06-26

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