PA8780201A1 - Derivados de pirasol sustituidos con heteroaril utiles para tratar trastornos hiperproliferativos y enfermedades asociadas con angiogénesis - Google Patents
Derivados de pirasol sustituidos con heteroaril utiles para tratar trastornos hiperproliferativos y enfermedades asociadas con angiogénesisInfo
- Publication number
- PA8780201A1 PA8780201A1 PA20088780201A PA8780201A PA8780201A1 PA 8780201 A1 PA8780201 A1 PA 8780201A1 PA 20088780201 A PA20088780201 A PA 20088780201A PA 8780201 A PA8780201 A PA 8780201A PA 8780201 A1 PA8780201 A1 PA 8780201A1
- Authority
- PA
- Panama
- Prior art keywords
- pirasol
- heteroaril
- angiogenesis
- hyperproliferative disorders
- useful
- Prior art date
Links
- 230000003463 hyperproliferative effect Effects 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 2
- 230000033115 angiogenesis Effects 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000004615 ingredient Substances 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/423—Oxazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Abstract
LA PRESENTE INVENCIÓN SE REFIERE A NUEVOS COMPUESTOS DE PIRAZOL SUSTITUIDOS CON HETEROARILO, A COMPOSICIONES FARMACÉUTICAS QUE CONTIENEN ESTOS COMPUESTOS Y AL USO DE ESTOS COMPUESTOS O COMPOSICIONES PARA TRATAR TRASTORNOS HIPERPROLIFERATIVOS Y/O ANGIOGÉNESIS, COMO UN ÚNICO AGENTE O EN COMBINACIÓN CON OTROS INGREDIENTES ACTIVOS O MEDIDAS TERAPÉUTICAS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US93081607P | 2007-05-18 | 2007-05-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
PA8780201A1 true PA8780201A1 (es) | 2009-02-09 |
Family
ID=39760483
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PA20088780201A PA8780201A1 (es) | 2007-05-18 | 2008-05-12 | Derivados de pirasol sustituidos con heteroaril utiles para tratar trastornos hiperproliferativos y enfermedades asociadas con angiogénesis |
Country Status (19)
Country | Link |
---|---|
US (1) | US8796253B2 (es) |
EP (1) | EP2148877A2 (es) |
JP (1) | JP5702138B2 (es) |
KR (1) | KR20100016617A (es) |
CN (1) | CN101765596B (es) |
AR (1) | AR066617A1 (es) |
AU (1) | AU2008253311A1 (es) |
BR (1) | BRPI0812361A2 (es) |
CA (1) | CA2687306A1 (es) |
CL (1) | CL2008001372A1 (es) |
IL (1) | IL201537A0 (es) |
MX (1) | MX2009012000A (es) |
PA (1) | PA8780201A1 (es) |
PE (1) | PE20090297A1 (es) |
RU (1) | RU2009146851A (es) |
TW (1) | TW200909428A (es) |
UY (1) | UY31080A1 (es) |
WO (1) | WO2008141731A2 (es) |
ZA (1) | ZA200907999B (es) |
Families Citing this family (50)
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BRPI0921257A2 (pt) * | 2008-11-14 | 2016-02-23 | Bayer Schering Pharma Ag | composto de arila heterociclicamente subsittuidos como inibidores hif |
DE102009041242A1 (de) | 2009-09-11 | 2011-12-15 | Bayer Schering Pharma Aktiengesellschaft | Heterocyclisch substituierte Aryl-Verbindungen und ihre Verwendung |
KR20110082570A (ko) * | 2008-11-14 | 2011-07-19 | 바이엘 쉐링 파마 악티엔게젤샤프트 | Hif 억제제로서 사용하기 위한 헤테로방향족 화합물 |
DE102008057344A1 (de) * | 2008-11-14 | 2010-05-20 | Bayer Schering Pharma Aktiengesellschaft | Aminoalkyl-substituierte Aryl-Verbindungen und ihre Verwendung |
DE102009041241A1 (de) | 2009-09-11 | 2011-08-04 | Bayer Schering Pharma Aktiengesellschaft, 13353 | Substituierte Aryl-Verbindungen und ihre Verwendung |
SI2382215T1 (sl) * | 2008-12-29 | 2020-06-30 | Sanofi | Derivati 2-piridin-2-il-pirazol-3(2H)-ona, njihova priprava in njihova terapevtska uporaba |
FR2940652B1 (fr) * | 2008-12-29 | 2011-02-11 | Sanofi Aventis | Derives de 2-pyridin-2-yl-pyrazol-3(2h)-one,leur preparation et leur application en therapeutique |
CA2748411A1 (fr) | 2008-12-29 | 2010-07-08 | Sanofi | Derives de 2-pyridin-2-yl-pyrazol-3(2h)-one, leur preparation et leur application en therapeutique comme activateurs de hif |
WO2010085582A1 (en) | 2009-01-23 | 2010-07-29 | Bristol-Myers Squibb Company | Substituted oxadiazole derivatives as s1p agonists in the treatment of autoimmune and inflammatory diseases |
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US8242284B1 (en) * | 2009-09-21 | 2012-08-14 | The United States Of America As Represented By The United States Department Of Energy | Anti-cancer agents based on 6-trifluoromethoxybenzimidazole derivatives and method of making |
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US9115120B2 (en) | 2012-08-24 | 2015-08-25 | Board Of Regents, The University Of Texas Systems | Heterocyclic modulators of HIF activity for treatment of disease |
EP2888256A4 (en) * | 2012-08-24 | 2016-02-17 | Univ Texas | HETEROCYCLIC HIF ACTIVITY MODULATORS FOR THE TREATMENT OF DISEASES |
CN104968667B (zh) * | 2013-02-05 | 2017-06-20 | 山东轩竹医药科技有限公司 | 四并环激酶抑制剂 |
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WO2017039318A1 (en) * | 2015-09-01 | 2017-03-09 | Kainos Medicine, Inc. | Benzimidazole derivatives for dna methylation inhibitors |
CN108164520B (zh) * | 2018-01-15 | 2021-03-19 | 东南大学 | 缺氧抑制剂与抗肿瘤药物的偶联化合物及其制备和应用 |
CA3097219A1 (en) | 2018-05-09 | 2019-11-14 | Akebia Therapeutics, Inc. | Process for preparing 2-[[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino]acetic acid |
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CN110257393A (zh) * | 2019-06-28 | 2019-09-20 | 西安医学院 | 翻译后水平低氧调控基因、应用及其调控方法 |
CN112110908A (zh) * | 2020-09-25 | 2020-12-22 | 山东大学 | 一种1,3-二取代吲唑类化合物及其制备方法和应用 |
CN112426422A (zh) * | 2020-12-02 | 2021-03-02 | 安徽医科大学 | 吡啶甲酰胺衍生物AMSP-30m在制备防治类风湿关节炎药物中的应用 |
WO2022131146A1 (ja) * | 2020-12-17 | 2022-06-23 | 国立大学法人京都大学 | 含窒素複素環式化合物 |
CN117800894A (zh) * | 2022-09-30 | 2024-04-02 | 苏州阿尔脉生物科技有限公司 | 饱和环类衍生物、包含其的药物组合物及其医药用途 |
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GB0508472D0 (en) * | 2005-04-26 | 2005-06-01 | Glaxo Group Ltd | Compounds |
CA2613522A1 (en) | 2005-06-27 | 2007-01-04 | Exelixis, Inc. | Imidazole based lxr modulators |
WO2007034279A2 (en) | 2005-09-19 | 2007-03-29 | Pfizer Products Inc. | C3a antagonists and pharmaceutical compositions thereof |
BR112012028651A2 (pt) * | 2010-05-08 | 2016-08-09 | Bayer Ip Gmbh | heterociclilbenzilpirazóis substituídos e uso do mesmo |
-
2008
- 2008-05-08 CA CA002687306A patent/CA2687306A1/en not_active Abandoned
- 2008-05-08 US US12/600,640 patent/US8796253B2/en not_active Expired - Fee Related
- 2008-05-08 BR BRPI0812361-6A2A patent/BRPI0812361A2/pt not_active IP Right Cessation
- 2008-05-08 JP JP2010508718A patent/JP5702138B2/ja not_active Expired - Fee Related
- 2008-05-08 AU AU2008253311A patent/AU2008253311A1/en not_active Abandoned
- 2008-05-08 EP EP20080758408 patent/EP2148877A2/en not_active Withdrawn
- 2008-05-08 CN CN200880015925.6A patent/CN101765596B/zh not_active Expired - Fee Related
- 2008-05-08 WO PCT/EP2008/003681 patent/WO2008141731A2/en active Application Filing
- 2008-05-08 RU RU2009146851/04A patent/RU2009146851A/ru not_active Application Discontinuation
- 2008-05-08 KR KR1020097023930A patent/KR20100016617A/ko not_active Application Discontinuation
- 2008-05-08 MX MX2009012000A patent/MX2009012000A/es not_active Application Discontinuation
- 2008-05-09 CL CL2008001372A patent/CL2008001372A1/es unknown
- 2008-05-09 UY UY31080A patent/UY31080A1/es not_active Application Discontinuation
- 2008-05-12 PA PA20088780201A patent/PA8780201A1/es unknown
- 2008-05-12 PE PE2008000823A patent/PE20090297A1/es not_active Application Discontinuation
- 2008-05-16 AR ARP080102099A patent/AR066617A1/es not_active Application Discontinuation
- 2008-05-16 TW TW097117928A patent/TW200909428A/zh unknown
-
2009
- 2009-10-15 IL IL201537A patent/IL201537A0/en unknown
- 2009-11-13 ZA ZA2009/07999A patent/ZA200907999B/en unknown
Also Published As
Publication number | Publication date |
---|---|
ZA200907999B (en) | 2011-06-29 |
CN101765596A (zh) | 2010-06-30 |
EP2148877A2 (en) | 2010-02-03 |
WO2008141731A3 (en) | 2009-03-26 |
WO2008141731A2 (en) | 2008-11-27 |
US20100249085A1 (en) | 2010-09-30 |
BRPI0812361A2 (pt) | 2015-02-03 |
US8796253B2 (en) | 2014-08-05 |
RU2009146851A (ru) | 2011-06-27 |
MX2009012000A (es) | 2009-11-19 |
JP5702138B2 (ja) | 2015-04-15 |
AU2008253311A1 (en) | 2008-11-27 |
KR20100016617A (ko) | 2010-02-12 |
CL2008001372A1 (es) | 2008-12-05 |
PE20090297A1 (es) | 2009-03-27 |
JP2010527378A (ja) | 2010-08-12 |
CA2687306A1 (en) | 2008-11-27 |
CN101765596B (zh) | 2015-04-29 |
TW200909428A (en) | 2009-03-01 |
UY31080A1 (es) | 2009-01-05 |
IL201537A0 (en) | 2010-05-31 |
AR066617A1 (es) | 2009-09-02 |
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