IN2013DN02555A - - Google Patents

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Publication number
IN2013DN02555A
IN2013DN02555A IN2555DEN2013A IN2013DN02555A IN 2013DN02555 A IN2013DN02555 A IN 2013DN02555A IN 2555DEN2013 A IN2555DEN2013 A IN 2555DEN2013A IN 2013DN02555 A IN2013DN02555 A IN 2013DN02555A
Authority
IN
India
Prior art keywords
compounds
processes
relates
disorders
preparing
Prior art date
Application number
Inventor
Alessandra Bartolozzi
Todd Bosanac
Zhidong Chen
Lombaert Stéphane De
Jonathon Alan Dines
John D Huber
Weimin Liu
Pui Leng Loke
Tina Marie Morwick
Alan Olague
Doris Riether
Heather Tye
Lifen Wu
Renee M Zindell
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44720163&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IN2013DN02555(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of IN2013DN02555A publication Critical patent/IN2013DN02555A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

The present invention relates to compounds of formula (I) and (IA) and pharmaceutically acceptable salts thereof wherein R1 R5 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds methods of using these compounds in the treatment of various diseases and disorders processes for preparing these compounds and intermediates useful in these processes.
IN2555DEN2013 2010-09-23 2011-09-20 IN2013DN02555A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38573310P 2010-09-23 2010-09-23
US201161533349P 2011-09-12 2011-09-12
PCT/US2011/052254 WO2012040139A1 (en) 2010-09-23 2011-09-20 Oxadiazole inhibitors of leukotriene production

Publications (1)

Publication Number Publication Date
IN2013DN02555A true IN2013DN02555A (en) 2015-08-07

Family

ID=44720163

Family Applications (1)

Application Number Title Priority Date Filing Date
IN2555DEN2013 IN2013DN02555A (en) 2010-09-23 2011-09-20

Country Status (18)

Country Link
US (1) US8575201B2 (en)
EP (1) EP2619197B1 (en)
JP (1) JP5713511B2 (en)
KR (1) KR20130109122A (en)
CN (1) CN103261193A (en)
AU (1) AU2011305667A1 (en)
BR (1) BR112013008638A2 (en)
CA (1) CA2812449A1 (en)
CL (1) CL2013000788A1 (en)
CO (1) CO6710902A2 (en)
EA (1) EA201300389A1 (en)
EC (1) ECSP13012548A (en)
IN (1) IN2013DN02555A (en)
MX (1) MX2013003202A (en)
PE (1) PE20131398A1 (en)
SG (1) SG188604A1 (en)
WO (1) WO2012040139A1 (en)
ZA (1) ZA201301747B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5862669B2 (en) * 2010-08-26 2016-02-16 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Leukotriene-producing oxadiazole inhibitors
CA2812449A1 (en) 2010-09-23 2012-03-29 Boehringer Ingelheim International Gmbh Oxadiazole inhibitors of leukotriene production
WO2012040137A1 (en) * 2010-09-23 2012-03-29 Boehringer Ingelheim International Gmbh Oxadiazole inhibitors of leukotriene production
AR089853A1 (en) 2012-02-01 2014-09-24 Boehringer Ingelheim Int OXADIAZOL INHIBITORS FROM THE PRODUCTION OF LEUCOTRIENS FOR COMBINATION THERAPY, PHARMACEUTICAL COMPOSITION, USE
ES2706399T3 (en) * 2013-02-04 2019-03-28 Janssen Pharmaceutica Nv Modulators of FLAP
ES2596248T3 (en) 2013-11-26 2017-01-05 Citrage N-Carbamoylputrescine to improve muscle protein synthesis

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1188410C (en) 1999-08-06 2005-02-09 詹森药业有限公司 Nonsteroid IL-5 inhibitor, its preparation method and medical composition containing the inhibitor
WO2005039485A2 (en) * 2003-08-13 2005-05-06 Chiron Corporation Gsk-3 inhibitors and uses thereof
US7319108B2 (en) 2004-01-25 2008-01-15 Sanofi-Aventis Deutschland Gmbh Aryl-substituted heterocycles, process for their preparation and their use as medicaments
EP1814877B1 (en) 2004-10-18 2009-03-11 Merck & Co., Inc. Diphenyl substituted alkanes as flap inhibitors
US7977359B2 (en) * 2005-11-04 2011-07-12 Amira Pharmaceuticals, Inc. 5-lipdxygenase-activating protein (FLAP) inhibitors
US8399666B2 (en) * 2005-11-04 2013-03-19 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
GB2431927B (en) 2005-11-04 2010-03-17 Amira Pharmaceuticals Inc 5-Lipoxygenase-activating protein (FLAP) inhibitors
EP2013174B1 (en) * 2006-04-11 2013-05-08 Merck Sharp & Dohme Corp. Diaryl substituted alkanes
WO2008002591A2 (en) 2006-06-26 2008-01-03 Amgen Inc Methods for treating atherosclerosis
EP2064204B1 (en) * 2006-09-01 2012-02-01 Merck Sharp & Dohme Corp. Inhibitors of 5 -lipoxygenase activating protein ( flap)
JP2010524861A (en) 2007-04-20 2010-07-22 メルク フロスト カナダ リミテツド Novel heteroaromatic compounds as inhibitors of stearoyl-coenzyme A delta-9 desaturase
EP2546232A1 (en) 2007-06-20 2013-01-16 Merck Sharp & Dohme Corp. Diphenyl Substituted Alkanes
EP2209761A4 (en) 2007-10-10 2012-01-04 Merck Sharp & Dohme Diphenyl substituted cycloalkanes
DE102008037790A1 (en) * 2008-08-14 2010-02-18 Merck Patent Gmbh Bicyclic triazole derivatives
MX2011004570A (en) * 2008-10-31 2011-06-17 Merck Sharp & Dohme P2x3, receptor antagonists for treatment of pain.
JP2012516885A (en) 2009-02-04 2012-07-26 ファイザー・インク 4-amino-7,8-dihydropyrido [4,3-d] pyrimidin-5 (6H) -one derivatives
CA2798514A1 (en) 2010-05-12 2011-11-17 P. Jeffrey Conn Heterocyclic sulfone mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
NZ605690A (en) * 2010-08-16 2014-06-27 Boehringer Ingelheim Int Oxadiazole inhibitors of leukotriene production
JP5862669B2 (en) * 2010-08-26 2016-02-16 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Leukotriene-producing oxadiazole inhibitors
CA2812449A1 (en) 2010-09-23 2012-03-29 Boehringer Ingelheim International Gmbh Oxadiazole inhibitors of leukotriene production
WO2012040137A1 (en) * 2010-09-23 2012-03-29 Boehringer Ingelheim International Gmbh Oxadiazole inhibitors of leukotriene production

Also Published As

Publication number Publication date
CN103261193A (en) 2013-08-21
BR112013008638A2 (en) 2016-06-21
JP5713511B2 (en) 2015-05-07
CL2013000788A1 (en) 2013-06-28
EA201300389A1 (en) 2013-09-30
SG188604A1 (en) 2013-04-30
EP2619197B1 (en) 2015-08-05
US20120295896A1 (en) 2012-11-22
US8575201B2 (en) 2013-11-05
ZA201301747B (en) 2014-08-27
CO6710902A2 (en) 2013-07-15
EP2619197A1 (en) 2013-07-31
JP2013537909A (en) 2013-10-07
WO2012040139A1 (en) 2012-03-29
CA2812449A1 (en) 2012-03-29
KR20130109122A (en) 2013-10-07
AU2011305667A1 (en) 2013-03-21
PE20131398A1 (en) 2013-12-19
ECSP13012548A (en) 2013-06-28
MX2013003202A (en) 2013-04-24

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