EA201990619A1 - Fgf21 мутанты и их применение - Google Patents

Fgf21 мутанты и их применение

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Publication number
EA201990619A1
EA201990619A1 EA201990619A EA201990619A EA201990619A1 EA 201990619 A1 EA201990619 A1 EA 201990619A1 EA 201990619 A EA201990619 A EA 201990619A EA 201990619 A EA201990619 A EA 201990619A EA 201990619 A1 EA201990619 A1 EA 201990619A1
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EA
Eurasian Patent Office
Prior art keywords
application
fgf21 mutant
fgf21 mutants
polypeptides
mutant polypeptides
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Application number
EA201990619A
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English (en)
Inventor
Кеннет В. Уолкер
Колин В. мл. Джегг
Рэнди И. Хейт
Эдвард Дж. Белоуски
Юэ-Шэн Ли
Марк Л. Майклс
Цзин Сюй
Мюриэль М. Эллисон
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Амген Инк.
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Application filed by Амген Инк. filed Critical Амген Инк.
Publication of EA201990619A1 publication Critical patent/EA201990619A1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Данное изобретение представляет молекулы нуклеиновой кислоты, кодирующие FGF21 мутантные полипептиды, FGF21 мутантные полипептиды, фармацевтические композиции, включающие FGF21 мутантные полипептиды, и способы лечения метаболических расстройств с использованием таких нуклеиновых кислот, полипептидов или фармацевтических композиций.
EA201990619A 2008-10-10 2009-10-08 Fgf21 мутанты и их применение EA201990619A1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US19576108P 2008-10-10 2008-10-10

Publications (1)

Publication Number Publication Date
EA201990619A1 true EA201990619A1 (ru) 2019-07-31

Family

ID=41571715

Family Applications (2)

Application Number Title Priority Date Filing Date
EA201100516A EA032727B1 (ru) 2008-10-10 2009-10-08 Мутантный резистентный к протеолизу полипептид fgf21 и его применение
EA201990619A EA201990619A1 (ru) 2008-10-10 2009-10-08 Fgf21 мутанты и их применение

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EA201100516A EA032727B1 (ru) 2008-10-10 2009-10-08 Мутантный резистентный к протеолизу полипептид fgf21 и его применение

Country Status (21)

Country Link
US (2) US9279013B2 (ru)
EP (1) EP2358749B1 (ru)
JP (2) JP5878757B2 (ru)
KR (1) KR101651703B1 (ru)
CN (1) CN102625811B (ru)
AU (1) AU2009302318A1 (ru)
CA (1) CA2739615C (ru)
CL (1) CL2011000792A1 (ru)
CO (1) CO6362020A2 (ru)
CR (1) CR20110245A (ru)
EA (2) EA032727B1 (ru)
IL (1) IL212061A0 (ru)
MA (1) MA32771B1 (ru)
MX (1) MX341149B (ru)
NZ (1) NZ592009A (ru)
PE (1) PE20120021A1 (ru)
SG (1) SG195542A1 (ru)
TN (1) TN2011000161A1 (ru)
UA (1) UA105016C2 (ru)
WO (1) WO2010042747A2 (ru)
ZA (1) ZA201103356B (ru)

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