EA201890156A1 - Антагонисты рецептора cgrp - Google Patents

Антагонисты рецептора cgrp

Info

Publication number
EA201890156A1
EA201890156A1 EA201890156A EA201890156A EA201890156A1 EA 201890156 A1 EA201890156 A1 EA 201890156A1 EA 201890156 A EA201890156 A EA 201890156A EA 201890156 A EA201890156 A EA 201890156A EA 201890156 A1 EA201890156 A1 EA 201890156A1
Authority
EA
Eurasian Patent Office
Prior art keywords
receptor antagonists
cgrp receptor
cgrp
compound
formula
Prior art date
Application number
EA201890156A
Other languages
English (en)
Inventor
Дэвид Эндрю Коутс
Кевин Чарльз Фортнер
Стивен Марк Месси
Джейсон Кеннет Майерс
Антонио Наварро
Майлз Гудман Сиджел
Рассел Дин Стаки
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA201890156A1 publication Critical patent/EA201890156A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/04—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Abstract

В изобретении предложено соединение формулы IIили его фармацевтически приемлемая соль.
EA201890156A 2015-08-12 2016-08-05 Антагонисты рецептора cgrp EA201890156A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562203996P 2015-08-12 2015-08-12
US201562266867P 2015-12-14 2015-12-14
PCT/US2016/045698 WO2017027345A1 (en) 2015-08-12 2016-08-05 Cgrp receptor antagonists

Publications (1)

Publication Number Publication Date
EA201890156A1 true EA201890156A1 (ru) 2018-07-31

Family

ID=56684300

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201890156A EA201890156A1 (ru) 2015-08-12 2016-08-05 Антагонисты рецептора cgrp

Country Status (36)

Country Link
US (1) US9708297B2 (ru)
EP (1) EP3334721B1 (ru)
JP (1) JP6619503B2 (ru)
KR (1) KR20180030582A (ru)
CN (1) CN107922385B (ru)
AU (1) AU2016304769B2 (ru)
BR (1) BR112018000513A2 (ru)
CA (1) CA2992622A1 (ru)
CL (1) CL2018000290A1 (ru)
CO (1) CO2018001383A2 (ru)
CR (1) CR20180043A (ru)
CY (1) CY1124413T1 (ru)
DK (1) DK3334721T3 (ru)
DO (1) DOP2018000042A (ru)
EA (1) EA201890156A1 (ru)
EC (1) ECSP18009366A (ru)
ES (1) ES2875600T3 (ru)
HK (1) HK1249095A1 (ru)
HR (1) HRP20211013T1 (ru)
HU (1) HUE055609T2 (ru)
IL (1) IL256572A (ru)
LT (1) LT3334721T (ru)
MD (1) MD3334721T2 (ru)
MX (1) MX2018001672A (ru)
NZ (1) NZ738990A (ru)
PE (1) PE20180655A1 (ru)
PH (1) PH12018500282A1 (ru)
PL (1) PL3334721T3 (ru)
PT (1) PT3334721T (ru)
RS (1) RS62041B1 (ru)
SI (1) SI3334721T1 (ru)
SV (1) SV2018005631A (ru)
TN (1) TN2018000026A1 (ru)
TW (1) TWI636041B (ru)
WO (1) WO2017027345A1 (ru)
ZA (1) ZA201800452B (ru)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR111665A1 (es) 2017-05-15 2019-08-07 Lilly Co Eli Derivados de 3-metil-pirrolidina-2,5-diona útiles como antagonistas del receptor cgrp
WO2018213056A1 (en) 2017-05-15 2018-11-22 Eli Lilly And Company Cgrp receptor antagonists
WO2019112024A1 (ja) * 2017-12-08 2019-06-13 キッセイ薬品工業株式会社 ピロリジン化合物
MA54823A (fr) 2019-01-24 2022-04-27 Takeda Pharmaceuticals Co Composé hétérocyclique et son utilisation
JP2021050161A (ja) 2019-09-25 2021-04-01 武田薬品工業株式会社 複素環化合物及びその用途
US20230096051A1 (en) * 2019-12-12 2023-03-30 Eli Lilly And Company Cgrp antigonists useful as tracer compounds for positron emission tomography

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001501628A (ja) * 1996-10-04 2001-02-06 ノボ ノルディスク アクティーゼルスカブ Ｎ―置換化アザ複素環式化合物
US6680387B2 (en) 2000-04-24 2004-01-20 Aryx Therapeutics Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis
WO2007141285A1 (en) * 2006-06-08 2007-12-13 Boehringer Ingelheim International Gmbh Treatment of gastrointestinal disorders with cgrp-antagonists
CA2680307A1 (en) * 2007-03-12 2008-09-18 Merck & Co., Inc. Monocyclic anilide spirolactam cgrp receptor antagonists
WO2012129013A1 (en) * 2011-03-18 2012-09-27 Merck Sharp & Dohme Corp. Piperidinone carboxamide spirohydantoin cgrp receptor antagonists
US9227972B2 (en) * 2012-05-09 2016-01-05 Merck Sharp & Dohme Corp. Aliphatic spirolactam CGRP receptor antagonists
FR3009961A1 (fr) * 2013-08-30 2015-03-06 Ct Hospitalier Universitaire De Clermont Fd Agent bloqueur des canaux cav3 dans le traitement de la douleur
WO2015161011A1 (en) * 2014-04-17 2015-10-22 Merck Sharp & Dohme Corp. Benzamide cgrp receptor antagonists

Also Published As

Publication number Publication date
ZA201800452B (en) 2019-07-31
DOP2018000042A (es) 2018-10-31
HRP20211013T1 (hr) 2021-10-01
KR20180030582A (ko) 2018-03-23
JP2018522933A (ja) 2018-08-16
CN107922385B (zh) 2020-09-08
DK3334721T3 (da) 2021-06-28
PH12018500282A1 (en) 2018-08-13
WO2017027345A1 (en) 2017-02-16
US9708297B2 (en) 2017-07-18
MX2018001672A (es) 2018-05-28
TN2018000026A1 (en) 2019-07-08
HK1249095A1 (zh) 2018-10-26
NZ738990A (en) 2019-03-29
LT3334721T (lt) 2021-07-26
TWI636041B (zh) 2018-09-21
HUE055609T2 (hu) 2021-12-28
MD3334721T2 (ro) 2021-09-30
ECSP18009366A (es) 2018-04-30
IL256572A (en) 2018-02-28
SI3334721T1 (sl) 2021-08-31
EP3334721B1 (en) 2021-04-28
TW201718481A (zh) 2017-06-01
US20170044138A1 (en) 2017-02-16
RS62041B1 (sr) 2021-07-30
PT3334721T (pt) 2021-06-17
JP6619503B2 (ja) 2019-12-11
CN107922385A (zh) 2018-04-17
BR112018000513A2 (pt) 2018-09-18
CL2018000290A1 (es) 2018-07-13
EP3334721A1 (en) 2018-06-20
CA2992622A1 (en) 2017-02-16
PL3334721T3 (pl) 2021-10-18
CY1124413T1 (el) 2022-07-22
AU2016304769B2 (en) 2018-09-13
CR20180043A (es) 2018-02-22
ES2875600T3 (es) 2021-11-10
CO2018001383A2 (es) 2018-05-21
AU2016304769A1 (en) 2018-01-25
SV2018005631A (es) 2018-04-24
PE20180655A1 (es) 2018-04-17

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