AR111665A1 - Derivados de 3-metil-pirrolidina-2,5-diona útiles como antagonistas del receptor cgrp - Google Patents

Derivados de 3-metil-pirrolidina-2,5-diona útiles como antagonistas del receptor cgrp

Info

Publication number
AR111665A1
AR111665A1 ARP180101138A ARP180101138A AR111665A1 AR 111665 A1 AR111665 A1 AR 111665A1 AR P180101138 A ARP180101138 A AR P180101138A AR P180101138 A ARP180101138 A AR P180101138A AR 111665 A1 AR111665 A1 AR 111665A1
Authority
AR
Argentina
Prior art keywords
useful
pirrolidine
diona
antagonists
derivatives
Prior art date
Application number
ARP180101138A
Other languages
English (en)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of AR111665A1 publication Critical patent/AR111665A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Abstract

La presente proporciona un compuesto de fórmula (1) o una sal aceptable para uso farmacéutico o hidrato del mismo, útil como un antagonista del receptor CGRP. Reivindicación 1: Un compuesto de la fórmula (1) o una sal aceptable para uso farmacéutico o hidrato del mismo.
ARP180101138A 2017-05-15 2018-05-02 Derivados de 3-metil-pirrolidina-2,5-diona útiles como antagonistas del receptor cgrp AR111665A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762506204P 2017-05-15 2017-05-15

Publications (1)

Publication Number Publication Date
AR111665A1 true AR111665A1 (es) 2019-08-07

Family

ID=62245454

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP180101138A AR111665A1 (es) 2017-05-15 2018-05-02 Derivados de 3-metil-pirrolidina-2,5-diona útiles como antagonistas del receptor cgrp

Country Status (18)

Country Link
US (1) US10336726B2 (es)
EP (1) EP3625221B1 (es)
JP (1) JP6794583B2 (es)
CN (1) CN110662741B (es)
AR (1) AR111665A1 (es)
CA (1) CA3061762C (es)
CY (1) CY1124032T1 (es)
DK (1) DK3625221T3 (es)
ES (1) ES2870325T3 (es)
HR (1) HRP20210655T1 (es)
HU (1) HUE054448T2 (es)
LT (1) LT3625221T (es)
PL (1) PL3625221T3 (es)
PT (1) PT3625221T (es)
RS (1) RS61657B1 (es)
SI (1) SI3625221T1 (es)
TW (1) TW201904955A (es)
WO (1) WO2018213059A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018213056A1 (en) 2017-05-15 2018-11-22 Eli Lilly And Company Cgrp receptor antagonists
EP4073059A1 (en) * 2019-12-12 2022-10-19 Eli Lilly and Company Cgrp antigonists useful as tracer compounds for positron emission tomography
CN115704811B (zh) * 2022-12-26 2023-03-31 南京威凯尔生物医药科技有限公司 一种高效液相色谱法检测乌布吉泮及其对映体和非对映体杂质的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6680387B2 (en) 2000-04-24 2004-01-20 Aryx Therapeutics Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis
US9227972B2 (en) 2012-05-09 2016-01-05 Merck Sharp & Dohme Corp. Aliphatic spirolactam CGRP receptor antagonists
TW201718574A (zh) 2015-08-12 2017-06-01 美國禮來大藥廠 Ｃｇｒｐ受體拮抗劑
TWI636041B (zh) * 2015-08-12 2018-09-21 美國禮來大藥廠 Ｃｇｒｐ受體拮抗劑

Also Published As

Publication number Publication date
CN110662741B (zh) 2022-08-16
CN110662741A (zh) 2020-01-07
CA3061762A1 (en) 2018-11-22
JP6794583B2 (ja) 2020-12-02
US10336726B2 (en) 2019-07-02
HUE054448T2 (hu) 2021-09-28
CA3061762C (en) 2021-11-09
SI3625221T1 (sl) 2021-04-30
US20180327384A1 (en) 2018-11-15
PL3625221T3 (pl) 2021-08-23
EP3625221B1 (en) 2021-03-03
RS61657B1 (sr) 2021-04-29
CY1124032T1 (el) 2022-05-27
TW201904955A (zh) 2019-02-01
WO2018213059A1 (en) 2018-11-22
LT3625221T (lt) 2021-04-26
DK3625221T3 (da) 2021-04-19
EP3625221A1 (en) 2020-03-25
HRP20210655T1 (hr) 2021-05-28
ES2870325T3 (es) 2021-10-26
PT3625221T (pt) 2021-04-15
JP2020519686A (ja) 2020-07-02

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