HK1249095A1 - Cgrp受體拮抗劑 - Google Patents

Cgrp受體拮抗劑

Info

Publication number
HK1249095A1
HK1249095A1 HK18107951.2A HK18107951A HK1249095A1 HK 1249095 A1 HK1249095 A1 HK 1249095A1 HK 18107951 A HK18107951 A HK 18107951A HK 1249095 A1 HK1249095 A1 HK 1249095A1
Authority
HK
Hong Kong
Prior art keywords
receptor antagonists
cgrp receptor
cgrp
antagonists
receptor
Prior art date
Application number
HK18107951.2A
Other languages
English (en)
Inventor
David Andrew Coates
Kevin Charles Fortner
Steven Marc Massey
Jason Kenneth Myers
Antonio Navarro
Miles Goodman Siegel
Russell Dean Stucky
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of HK1249095A1 publication Critical patent/HK1249095A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/03—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C309/04—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton containing only one sulfo group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
HK18107951.2A 2015-08-12 2018-06-21 Cgrp受體拮抗劑 HK1249095A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562203996P 2015-08-12 2015-08-12
US201562266867P 2015-12-14 2015-12-14
PCT/US2016/045698 WO2017027345A1 (en) 2015-08-12 2016-08-05 Cgrp receptor antagonists

Publications (1)

Publication Number Publication Date
HK1249095A1 true HK1249095A1 (zh) 2018-10-26

Family

ID=56684300

Family Applications (1)

Application Number Title Priority Date Filing Date
HK18107951.2A HK1249095A1 (zh) 2015-08-12 2018-06-21 Cgrp受體拮抗劑

Country Status (36)

Country Link
US (1) US9708297B2 (zh)
EP (1) EP3334721B1 (zh)
JP (1) JP6619503B2 (zh)
KR (1) KR20180030582A (zh)
CN (1) CN107922385B (zh)
AU (1) AU2016304769B2 (zh)
BR (1) BR112018000513A2 (zh)
CA (1) CA2992622A1 (zh)
CL (1) CL2018000290A1 (zh)
CO (1) CO2018001383A2 (zh)
CR (1) CR20180043A (zh)
CY (1) CY1124413T1 (zh)
DK (1) DK3334721T3 (zh)
DO (1) DOP2018000042A (zh)
EA (1) EA201890156A1 (zh)
EC (1) ECSP18009366A (zh)
ES (1) ES2875600T3 (zh)
HK (1) HK1249095A1 (zh)
HR (1) HRP20211013T1 (zh)
HU (1) HUE055609T2 (zh)
IL (1) IL256572A (zh)
LT (1) LT3334721T (zh)
MD (1) MD3334721T2 (zh)
MX (1) MX2018001672A (zh)
NZ (1) NZ738990A (zh)
PE (1) PE20180655A1 (zh)
PH (1) PH12018500282A1 (zh)
PL (1) PL3334721T3 (zh)
PT (1) PT3334721T (zh)
RS (1) RS62041B1 (zh)
SI (1) SI3334721T1 (zh)
SV (1) SV2018005631A (zh)
TN (1) TN2018000026A1 (zh)
TW (1) TWI636041B (zh)
WO (1) WO2017027345A1 (zh)
ZA (1) ZA201800452B (zh)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201904955A (zh) 2017-05-15 2019-02-01 美商美國禮來大藥廠 可作為cgrp受體拮抗劑之3-甲基-吡咯啶-2,5-二酮衍生物
WO2018213056A1 (en) 2017-05-15 2018-11-22 Eli Lilly And Company Cgrp receptor antagonists
WO2019112024A1 (ja) * 2017-12-08 2019-06-13 キッセイ薬品工業株式会社 ピロリジン化合物
WO2020153414A1 (ja) 2019-01-24 2020-07-30 武田薬品工業株式会社 複素環化合物及びその用途
JP2021050161A (ja) 2019-09-25 2021-04-01 武田薬品工業株式会社 複素環化合物及びその用途
EP4073059A1 (en) 2019-12-12 2022-10-19 Eli Lilly and Company Cgrp antigonists useful as tracer compounds for positron emission tomography

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0934314A1 (en) * 1996-10-04 1999-08-11 Novo Nordisk A/S N-substituted azaheterocyclic compounds
US6680387B2 (en) 2000-04-24 2004-01-20 Aryx Therapeutics Materials and methods for the treatment of diabetes, hyperlipidemia, hypercholesterolemia, and atherosclerosis
EP2029234A1 (en) * 2006-06-08 2009-03-04 Boehringer Ingelheim International GmbH Treatment of gastrointestinal disorders with cgrp-antagonists
CA2680307A1 (en) * 2007-03-12 2008-09-18 Merck & Co., Inc. Monocyclic anilide spirolactam cgrp receptor antagonists
EP2685826B1 (en) * 2011-03-18 2016-02-03 Merck Sharp & Dohme Corp. Piperidinone carboxamide spirohydantoin cgrp receptor antagonists
US9227972B2 (en) * 2012-05-09 2016-01-05 Merck Sharp & Dohme Corp. Aliphatic spirolactam CGRP receptor antagonists
FR3009961A1 (fr) * 2013-08-30 2015-03-06 Ct Hospitalier Universitaire De Clermont Fd Agent bloqueur des canaux cav3 dans le traitement de la douleur
WO2015161011A1 (en) * 2014-04-17 2015-10-22 Merck Sharp & Dohme Corp. Benzamide cgrp receptor antagonists

Also Published As

Publication number Publication date
DK3334721T3 (da) 2021-06-28
JP6619503B2 (ja) 2019-12-11
PE20180655A1 (es) 2018-04-17
EP3334721B1 (en) 2021-04-28
AU2016304769A1 (en) 2018-01-25
ES2875600T3 (es) 2021-11-10
EA201890156A1 (ru) 2018-07-31
PH12018500282A1 (en) 2018-08-13
US9708297B2 (en) 2017-07-18
EP3334721A1 (en) 2018-06-20
IL256572A (en) 2018-02-28
AU2016304769B2 (en) 2018-09-13
JP2018522933A (ja) 2018-08-16
DOP2018000042A (es) 2018-10-31
TN2018000026A1 (en) 2019-07-08
CA2992622A1 (en) 2017-02-16
PT3334721T (pt) 2021-06-17
MD3334721T2 (ro) 2021-09-30
CN107922385B (zh) 2020-09-08
BR112018000513A2 (pt) 2018-09-18
KR20180030582A (ko) 2018-03-23
HRP20211013T1 (hr) 2021-10-01
SV2018005631A (es) 2018-04-24
CL2018000290A1 (es) 2018-07-13
TWI636041B (zh) 2018-09-21
MX2018001672A (es) 2018-05-28
HUE055609T2 (hu) 2021-12-28
TW201718481A (zh) 2017-06-01
US20170044138A1 (en) 2017-02-16
PL3334721T3 (pl) 2021-10-18
RS62041B1 (sr) 2021-07-30
CR20180043A (es) 2018-02-22
LT3334721T (lt) 2021-07-26
WO2017027345A1 (en) 2017-02-16
ECSP18009366A (es) 2018-04-30
CY1124413T1 (el) 2022-07-22
CN107922385A (zh) 2018-04-17
CO2018001383A2 (es) 2018-05-21
NZ738990A (en) 2019-03-29
SI3334721T1 (sl) 2021-08-31
ZA201800452B (en) 2019-07-31

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