EA201590022A1 - Новые производные 1,3-дигидро-2h-бензимидазол-2-она, замещенные гетероциклами, в качестве противовирусных средств против респираторного синцитиального вируса - Google Patents

Новые производные 1,3-дигидро-2h-бензимидазол-2-она, замещенные гетероциклами, в качестве противовирусных средств против респираторного синцитиального вируса

Info

Publication number
EA201590022A1
EA201590022A1 EA201590022A EA201590022A EA201590022A1 EA 201590022 A1 EA201590022 A1 EA 201590022A1 EA 201590022 A EA201590022 A EA 201590022A EA 201590022 A EA201590022 A EA 201590022A EA 201590022 A1 EA201590022 A1 EA 201590022A1
Authority
EA
Eurasian Patent Office
Prior art keywords
virus
benzimidazol
heterocycles
dihydro
new derivatives
Prior art date
Application number
EA201590022A
Other languages
English (en)
Other versions
EA028240B1 (ru
Inventor
Абделлах Тахри
Тим Хьюго Мария Йонкерс
Пьер Жан-Мари Бернар Рабуассон
Сандрин Мари Элен Вендевилль
Лили Ху
Самюэль Доминик Демэн
Людвиг Поль Коиманс
Original Assignee
ЯНССЕН Ар ЭНД Ди АЙРЛЭНД
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ЯНССЕН Ар ЭНД Ди АЙРЛЭНД filed Critical ЯНССЕН Ар ЭНД Ди АЙРЛЭНД
Publication of EA201590022A1 publication Critical patent/EA201590022A1/ru
Publication of EA028240B1 publication Critical patent/EA028240B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Abstract

Настоящее изобретение относится к новым производным 1,3-дигидро-2H-бензимидазол-2-она, замещенных гетероциклами, характеризующимся формулой (I)их стереоизомерным формам, а также их фармацевтически приемлемым солям присоединения и сольватам, где R, R, Z и Het имеют значение, определенное в формуле изобретения. Соединения по настоящему изобретению применяются в качестве ингибиторов репликации респираторного синцитиального вируса (RSV). Настоящее изобретение дополнительно относится к получению таких новых соединений, композиций, содержащих эти соединения, а также к соединениям для применения при лечении инфекции, вызванной респираторным синцитиальным вирусом.
EA201590022A 2012-06-15 2013-06-14 Производные 1,3-дигидро-2h-бензимидазол-2-она, замещенные гетероциклами, в качестве противовирусных средств против респираторного синцитиального вируса EA028240B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12172271 2012-06-15
EP12182550 2012-08-31
PCT/EP2013/062322 WO2013186333A1 (en) 2012-06-15 2013-06-14 1,3 -dihydro- 2h-benzimidazol- 2 -one derivatives substituted with heterocycles as respiratory syncytial virus antiviral agents

Publications (2)

Publication Number Publication Date
EA201590022A1 true EA201590022A1 (ru) 2015-04-30
EA028240B1 EA028240B1 (ru) 2017-10-31

Family

ID=48613635

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201590022A EA028240B1 (ru) 2012-06-15 2013-06-14 Производные 1,3-дигидро-2h-бензимидазол-2-она, замещенные гетероциклами, в качестве противовирусных средств против респираторного синцитиального вируса

Country Status (20)

Country Link
US (2) US20150111868A1 (ru)
EP (1) EP2864323B1 (ru)
JP (1) JP6259451B2 (ru)
KR (1) KR102092612B1 (ru)
CN (1) CN104540817B (ru)
AR (1) AR091455A1 (ru)
AU (1) AU2013276519B2 (ru)
CA (1) CA2873920C (ru)
CY (1) CY1119289T1 (ru)
DK (1) DK2864323T3 (ru)
EA (1) EA028240B1 (ru)
ES (1) ES2632914T3 (ru)
HR (1) HRP20171050T1 (ru)
HU (1) HUE033848T2 (ru)
LT (1) LT2864323T (ru)
PL (1) PL2864323T3 (ru)
PT (1) PT2864323T (ru)
SI (1) SI2864323T1 (ru)
TW (1) TWI643850B (ru)
WO (1) WO2013186333A1 (ru)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI527814B (zh) 2010-12-16 2016-04-01 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之氮雜苯并咪唑類
TWI515187B (zh) 2010-12-16 2016-01-01 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之吲哚類
TWI501967B (zh) * 2010-12-16 2015-10-01 Janssen R&D Ireland 作為呼吸道融合病毒抗病毒劑之氮雜吲哚類
LT2864323T (lt) 2012-06-15 2017-07-25 Janssen Sciences Ireland Uc 1,3-dihidro-2h-benzimidazol-2-ono dariniai, turintys heterociklų pakaitų, kaip antivirusiniai agentai prieš respiratorinį sincitinį virusą
SG11201600977XA (en) 2013-08-21 2016-03-30 Alios Biopharma Inc Antiviral compounds
SG10201901010PA (en) * 2014-08-05 2019-03-28 Alios Biopharma Inc Combination therapy for treating a paramyxovirus
MA41614A (fr) 2015-02-25 2018-01-02 Alios Biopharma Inc Composés antiviraux
CA3077309A1 (en) 2017-09-29 2019-04-04 Enanta Pharmaceuticals, Inc. Combination pharmaceutical agents as rsv inhibitors
WO2021083998A1 (en) * 2019-10-30 2021-05-06 Janssen Sciences Ireland Unlimited Company Synthesis of 3-({5-chloro-1-[3-(methylsulfonyl)propyl]-1h-indol-2 yl} methyl)-1-(2,2,2-trifluoroethyl)-1,3-dihydro-2h-imidazo[4,5-c]pyridin-2-one

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0960102A1 (en) 1996-07-08 1999-12-01 Du Pont Pharmaceuticals Company AMIDINOINDOLES, AMIDINOAZOLES, AND ANALOGS THEREOF AS INHIBITORS OF FACTOR Xa AND OF THROMBIN
AU1099000A (en) 1998-10-05 2000-04-26 Axys Pharmaceuticals, Inc. Novel compounds and compositions for treating hepatitis c infections
CZ20012006A3 (cs) 1998-12-18 2002-03-13 Axys Pharmaceuticals, Inc. Sloučenina a farmaceutický prostředek
DE60013836T2 (de) 1999-06-28 2006-01-19 Janssen Pharmaceutica N.V. Replikationsinhibitoren des respiratorischen synzytialvirus
TR200103806T2 (tr) 1999-06-28 2002-06-21 Janssen Pharmaceutica N. V. Solunum sistemi sinsitiyal virüsünün replikasyonunu inhibe edici maddeler.
WO2001012600A1 (en) 1999-08-12 2001-02-22 Cor Therapeutics, Inc. INHIBITORS OF FACTOR Xa
US20020019395A1 (en) 2000-02-01 2002-02-14 Bing-Yan Zhu Indalone and benzimidazolone inhibitors of factor Xa
WO2001057020A1 (en) 2000-02-01 2001-08-09 Cor Therapeutics, Inc. INDOLE AND BENZIMIDAZOLE INHIBITORS OF FACTOR Xa
US6489338B2 (en) * 2000-06-13 2002-12-03 Bristol-Myers Squibb Company Imidazopyridine and imidazopyrimidine antiviral agents
US6506738B1 (en) 2000-09-27 2003-01-14 Bristol-Myers Squibb Company Benzimidazolone antiviral agents
EP1461036A4 (en) * 2001-12-10 2005-11-16 Bristol Myers Squibb Co BIS HYDROCHLORIDE SALT MONOHYDRATE OF A SYNCYTIAL RESPIRATORY VIRUS FUSION INHIBITOR (RSV)
US6919331B2 (en) 2001-12-10 2005-07-19 Bristol-Myers Squibb Company Substituted 2-methyl-benzimidazole respiratory syncytial virus antiviral agents
AU2002358219A1 (en) 2001-12-21 2003-07-15 Sense Proteomic Limited Protein analysis using mass spectrometry
AU2003294249A1 (en) 2002-11-08 2004-06-03 Trimeris, Inc. Hetero-substituted benzimidazole compounds and antiviral uses thereof
PE20050068A1 (es) * 2003-02-06 2005-03-11 Novartis Ag 2-cianopirrolopirimidinas como inhibidores de la catepsina s
US7343930B2 (en) 2004-12-03 2008-03-18 Masco Corporation Of Indiana Sprayer with non-faucet control
MY140748A (en) 2004-12-06 2010-01-15 Astrazeneca Ab Novel pyrrolo [3,2-d] pyrimidin-4-one derivatives and their use in therapy
WO2008147697A1 (en) * 2007-05-22 2008-12-04 Boehringer Ingelheim International Gmbh Benzimidazolone chymase inhibitors
FR2926556B1 (fr) 2008-01-22 2010-02-19 Sanofi Aventis Derives de carboxamides n-azabicycliques, leur preparation et leur application en therapeutique
TWI515187B (zh) 2010-12-16 2016-01-01 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之吲哚類
TWI527814B (zh) * 2010-12-16 2016-04-01 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之氮雜苯并咪唑類
TWI530495B (zh) * 2010-12-16 2016-04-21 健生科學愛爾蘭無限公司 苯并咪唑呼吸道融合病毒抑制劑
TWI501967B (zh) 2010-12-16 2015-10-01 Janssen R&D Ireland 作為呼吸道融合病毒抗病毒劑之氮雜吲哚類
TWI541241B (zh) 2010-12-16 2016-07-11 健生科學愛爾蘭無限公司 作為呼吸道融合病毒抗病毒劑之咪唑并吡啶類
US20130261561A1 (en) 2010-12-17 2013-10-03 Sanofi-Aventis Deutschland Gmbh Medicament Administration
KR20150033645A (ko) 2012-06-15 2015-04-01 얀센 알 앤드 디 아일랜드 호흡기 합포체 바이러스의 항바이러스제로서의 벤즈이미다졸로 치환된 1,3-디하이드로-2h-벤즈이미다졸-2-온 유도체
CN104507916A (zh) 2012-06-15 2015-04-08 爱尔兰詹森研发公司 作为呼吸道合胞病毒抗病毒剂的被苯并咪唑取代的4-取代的1,3-二氢-2h-苯并咪唑-2-酮衍生物
LT2864323T (lt) 2012-06-15 2017-07-25 Janssen Sciences Ireland Uc 1,3-dihidro-2h-benzimidazol-2-ono dariniai, turintys heterociklų pakaitų, kaip antivirusiniai agentai prieš respiratorinį sincitinį virusą
KR20150032283A (ko) 2012-06-15 2015-03-25 얀센 알 앤드 디 아일랜드 호흡기 합포체 바이러스의 항바이러스제로서의 헤테로사이클로 치환된 1,3-디하이드로-2h-벤즈이미다졸-2-온 유도체
CN104903313B (zh) 2012-10-16 2017-12-29 爱尔兰詹森科学公司 Rsv抗病毒化合物

Also Published As

Publication number Publication date
WO2013186333A1 (en) 2013-12-19
KR102092612B1 (ko) 2020-03-25
TWI643850B (zh) 2018-12-11
US20160122346A1 (en) 2016-05-05
AR091455A1 (es) 2015-02-04
EP2864323B1 (en) 2017-04-19
TW201410669A (zh) 2014-03-16
EP2864323A1 (en) 2015-04-29
CY1119289T1 (el) 2018-02-14
JP2015519386A (ja) 2015-07-09
KR20150033646A (ko) 2015-04-01
CA2873920C (en) 2021-07-20
PL2864323T3 (pl) 2017-09-29
DK2864323T3 (en) 2017-08-14
AU2013276519A1 (en) 2014-12-04
ES2632914T3 (es) 2017-09-18
PT2864323T (pt) 2017-07-14
CN104540817B (zh) 2017-03-01
LT2864323T (lt) 2017-07-25
AU2013276519B2 (en) 2017-05-25
US20150111868A1 (en) 2015-04-23
CA2873920A1 (en) 2013-12-19
HUE033848T2 (en) 2018-01-29
JP6259451B2 (ja) 2018-01-10
HRP20171050T1 (hr) 2017-10-06
SI2864323T1 (sl) 2017-08-31
EA028240B1 (ru) 2017-10-31
CN104540817A (zh) 2015-04-22
US9845321B2 (en) 2017-12-19

Similar Documents

Publication Publication Date Title
EA201590023A1 (ru) Новые 4-замещенные производные 1,3-дигидро-2h-бензимидазол-2-она, замещенные бензимидазолами, в качестве противовирусных средств против респираторного синцитиального вируса
EA201590020A1 (ru) Новые производные 1,3-дигидро-2h-бензимидазол-2-она, замещенные бензимидазолами, в качестве противовирусных средств против респираторного синцитиального вируса
EA201590022A1 (ru) Новые производные 1,3-дигидро-2h-бензимидазол-2-она, замещенные гетероциклами, в качестве противовирусных средств против респираторного синцитиального вируса
EA201590021A1 (ru) Новые замещенные производные 1,3-дигидро-2h-бензимидазол-2-она, замещенные гетероциклами, в качестве противовирусных средств против респираторного синцитиального вируса
EA201590748A1 (ru) Противовирусные соединения против rsv
EA201591195A1 (ru) Новые хинолоновые производные
EA201790389A1 (ru) Пирролопиримидиновые соединения, используемые в качестве агониста tlr7
EA201591890A1 (ru) Производные n-фенилкарбоксамида и их применение в качестве лекарственных препаратов для лечения гепатита b
EA201390766A1 (ru) БЕНЗОКСАЗЕПИНЫ КАК ИНГИБИТОРЫ PI3K/mTOR И СПОСОБЫ ИХ ИСПОЛЬЗОВАНИЯ И ПОЛУЧЕНИЯ
GEP20207105B (en) 1,1,1-trifluoro-3-hydroxypropan-2-yl carbamate derivatives and 1,1,1-trifluoro-4-hydroxybutan-2yl carbamate derivatives as magl inhibitors
EA202090486A3 (ru) Соединения для лечения спинальной мышечной атрофии
EA201492204A1 (ru) Нуклеозиды на основе урацила и спирооксетана
EA201490228A1 (ru) Новые производные трифторметилоксадиазола и их применение для лечения заболевания
EA201491672A1 (ru) Гетероциклильные соединения как ингибиторы mek
EA201891063A1 (ru) Производные дигидроимидазопиразинона, применимые в лечении рака
EA201791955A1 (ru) ИНГИБИТОРЫ TGF-β
MD20160078A2 (ru) Ингибиторы Syk
MX2015017192A (es) Inhibidores de fosfatidilinositol 3-cinasa.
EA201491060A1 (ru) Новые производные трифторметилоксадиазола и их применение для лечения заболевания
EA201692249A1 (ru) Ингибиторы фосфатидилинозитол-3-киназы
ECSP14004812A (es) Triazolopiridinas sustituidas
EA201600366A1 (ru) Производные бензимидазол-пролина
EA201690888A1 (ru) Новые гетероциклические соединения
EA201490471A1 (ru) Пиридазиноновые соединения и их применение в качестве ингибиторов daao
EA201490103A1 (ru) Гидроксиметиларилзамещенные пирролотриазины в качестве ингибиторов alk1

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG TJ TM