EA201590092A1 - АЗОТСОДЕРЖАЩИЕ 5-ЧЛЕННЫЕ ГЕТЕРОЦИКЛЫ, ЗАМЕЩЕННЫЕ КАРБОКСАМИДОМ ИЛИ СУЛЬФОНАМИДОМ, В КАЧЕСТВЕ МОДУЛЯТОРОВ ДЛЯ ЯДЕРНОГО ОРФАНОВОГО РЕЦЕПТОРА RORγ - Google Patents
АЗОТСОДЕРЖАЩИЕ 5-ЧЛЕННЫЕ ГЕТЕРОЦИКЛЫ, ЗАМЕЩЕННЫЕ КАРБОКСАМИДОМ ИЛИ СУЛЬФОНАМИДОМ, В КАЧЕСТВЕ МОДУЛЯТОРОВ ДЛЯ ЯДЕРНОГО ОРФАНОВОГО РЕЦЕПТОРА RORγInfo
- Publication number
- EA201590092A1 EA201590092A1 EA201590092A EA201590092A EA201590092A1 EA 201590092 A1 EA201590092 A1 EA 201590092A1 EA 201590092 A EA201590092 A EA 201590092A EA 201590092 A EA201590092 A EA 201590092A EA 201590092 A1 EA201590092 A1 EA 201590092A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- modulators
- carboxamide
- rorγ
- sulphonamide
- nitrogen
- Prior art date
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- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
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Abstract
В настоящем изобретении предложены модуляторы для ядерного орфанового рецептора RORγ и способы лечения заболеваний, опосредованных RORγ, путем введения указанных новых модуляторов RORγ человеку или млекопитающему, нуждающемуся в указанном лечении. В частности, в настоящем изобретении предложены циклические соединения, содержащие карбоксамид, формул (1)-(5)энантиомеры, диастереомеры, таутомеры, N-оксиды, сольваты и фармацевтически приемлемые соли указанных соединений.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US201261681296P | 2012-08-09 | 2012-08-09 | |
EP12005789 | 2012-08-09 | ||
PCT/EP2013/001594 WO2014023367A1 (en) | 2012-08-09 | 2013-05-29 | Carboxamide or sulfonamide substituted nitrogen-containing 5-membered heterocycles as modulators for the orphan nuclear receptor ror gamma |
Publications (3)
Publication Number | Publication Date |
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EA201590092A1 true EA201590092A1 (ru) | 2015-08-31 |
EA027953B1 EA027953B1 (ru) | 2017-09-29 |
EA027953B9 EA027953B9 (ru) | 2018-01-31 |
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Family Applications (1)
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EA201590092A EA027953B9 (ru) | 2012-08-09 | 2013-05-29 | АЗОТСОДЕРЖАЩИЕ 5-ЧЛЕННЫЕ ГЕТЕРОЦИКЛЫ, ЗАМЕЩЕННЫЕ КАРБОКСАМИДОМ ИЛИ СУЛЬФОНАМИДОМ, В КАЧЕСТВЕ МОДУЛЯТОРОВ ДЛЯ ЯДЕРНОГО ОРФАНОВОГО РЕЦЕПТОРА RORγ |
Country Status (28)
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US (1) | US9458104B2 (ru) |
EP (2) | EP3118189A1 (ru) |
JP (1) | JP6097829B2 (ru) |
KR (1) | KR101732973B1 (ru) |
CN (1) | CN104603105B (ru) |
AR (1) | AR091193A1 (ru) |
AU (1) | AU2013301914B2 (ru) |
BR (1) | BR112015002738A2 (ru) |
CA (1) | CA2879478C (ru) |
CL (1) | CL2015000300A1 (ru) |
CO (1) | CO7310529A2 (ru) |
EA (1) | EA027953B9 (ru) |
GT (1) | GT201500024A (ru) |
HK (1) | HK1211584A1 (ru) |
IL (1) | IL236695A (ru) |
IN (1) | IN2015DN01815A (ru) |
JO (1) | JO3215B1 (ru) |
MX (1) | MX364453B (ru) |
NO (1) | NO344067B1 (ru) |
NZ (1) | NZ704512A (ru) |
PE (1) | PE20150463A1 (ru) |
PH (1) | PH12015500142B1 (ru) |
SG (1) | SG11201500955RA (ru) |
TW (2) | TW201527278A (ru) |
UA (1) | UA115145C2 (ru) |
UY (1) | UY34833A (ru) |
WO (1) | WO2014023367A1 (ru) |
ZA (1) | ZA201500534B (ru) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
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TWI659019B (zh) * | 2014-02-28 | 2019-05-11 | 日商帝人製藥股份有限公司 | 吡唑醯胺衍生物 |
US9868724B2 (en) * | 2014-05-28 | 2018-01-16 | Glaxosmithkline Intellectual Property Development Limited | Compounds |
CA2949559C (en) * | 2014-06-06 | 2023-08-29 | Research Triangle Institute | Apelin receptor (apj) agonists and uses thereof |
JOP20200117A1 (ar) | 2014-10-30 | 2017-06-16 | Janssen Pharmaceutica Nv | كحولات ثلاثي فلوروميثيل كمُعدلات للمستقبل النووي جاما تي المرتبط بحمض الريتيونَويك ROR?t |
TR201820513T4 (tr) | 2014-10-30 | 2019-02-21 | Janssen Pharmaceutica Nv | Roryt modülatörleri olarak tiazoller. |
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