EA201692204A1 - Композиции и способы модулирования экспрессии фактора комплемента b - Google Patents

Композиции и способы модулирования экспрессии фактора комплемента b

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Publication number
EA201692204A1
EA201692204A1 EA201692204A EA201692204A EA201692204A1 EA 201692204 A1 EA201692204 A1 EA 201692204A1 EA 201692204 A EA201692204 A EA 201692204A EA 201692204 A EA201692204 A EA 201692204A EA 201692204 A1 EA201692204 A1 EA 201692204A1
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EA
Eurasian Patent Office
Prior art keywords
compositions
methods
factor
modulating
expression
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Application number
EA201692204A
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English (en)
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EA036496B1 (ru
Inventor
Тража П. Пракаш
Пунит П. Сэт
Эрик Э. Свэйз
Тамар Р. Гроссмэн
Майкл Л. Маккалеб
Эндрю Т. Ватт
Сьюзан М. Фрэйер
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Ионис Фармасьютикалз, Инк.
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Application filed by Ионис Фармасьютикалз, Инк. filed Critical Ионис Фармасьютикалз, Инк.
Publication of EA201692204A1 publication Critical patent/EA201692204A1/ru
Publication of EA036496B1 publication Critical patent/EA036496B1/ru

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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • C12N2310/3525—MOE, methoxyethoxy

Abstract

В вариантах реализации настоящего изобретения предложены способы, соединения и композиции для лечения, предупреждения или облегчения заболевания, связанного с дисрегуляцией альтернативного пути комплемента, посредством введения субъекту специфического ингибитора фактора комплемента В (CFB).
EA201692204A 2014-05-01 2015-05-01 Конъюгированные олигонуклеотиды для модулирования экспрессии фактора комплемента b EA036496B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461987471P 2014-05-01 2014-05-01
US201462076273P 2014-11-06 2014-11-06
PCT/US2015/028916 WO2015168635A2 (en) 2014-05-01 2015-05-01 Compositions and methods for modulating complement factor b expression

Publications (2)

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EA201692204A1 true EA201692204A1 (ru) 2017-04-28
EA036496B1 EA036496B1 (ru) 2020-11-17

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US (4) US10280423B2 (ru)
EP (3) EP3137596B1 (ru)
JP (2) JP6637442B2 (ru)
KR (1) KR102369736B1 (ru)
CN (2) CN106232804B (ru)
AU (1) AU2015252858C1 (ru)
BR (1) BR112016022593B1 (ru)
CA (1) CA2943894A1 (ru)
CL (2) CL2016002764A1 (ru)
CR (2) CR20200228A (ru)
DK (1) DK3137596T3 (ru)
DO (1) DOP2016000291A (ru)
EA (1) EA036496B1 (ru)
ES (2) ES2745825T3 (ru)
HR (1) HRP20191664T1 (ru)
HU (1) HUE046272T2 (ru)
IL (2) IL247883B (ru)
LT (1) LT3137596T (ru)
MX (1) MX2016014294A (ru)
PE (2) PE20170010A1 (ru)
PH (1) PH12016502062A1 (ru)
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PT (1) PT3137596T (ru)
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RU (1) RU2701645C2 (ru)
SG (2) SG11201608502TA (ru)
SI (1) SI3137596T1 (ru)
WO (1) WO2015168635A2 (ru)

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EP3336189A1 (en) * 2012-04-20 2018-06-20 Ionis Pharmaceuticals, Inc. Oligomeric compounds comprising bicyclic nucleotides and uses thereof
PL2992009T3 (pl) 2013-05-01 2020-11-30 Ionis Pharmaceuticals, Inc. Kompozycje i sposoby modulowania ekspresji apolipoproteiny(a)
MX371518B (es) * 2013-09-13 2020-01-31 Ionis Pharmaceuticals Inc Moduladores del factor del complemento b.
RS59182B1 (sr) 2014-05-01 2019-10-31 Ionis Pharmaceuticals Inc Kompozicije i postupci za modulaciju ekspresije faktora b komplementa
ES2812099T3 (es) 2014-05-01 2021-03-16 Ionis Pharmaceuticals Inc Composiciones y métodos para modular la expresión del receptor de la hormona del crecimiento
SG11201702877TA (en) 2014-10-10 2017-05-30 Hoffmann La Roche Galnac phosphoramidites, nucleic acid conjugates thereof and their use
MX2018005277A (es) * 2015-11-06 2018-08-01 Ionis Pharmaceuticals Inc Modular la expresion de apolipoproteina (a).
EP3484908A4 (en) 2016-07-15 2020-04-08 AM Chemicals Llc NON-NUCLEOSIDIC SOLID CARRIERS AND PHOSPHORAMIDITE BUILDING BLOCKS FOR OLIGONUCLEOTID SYNTHESIS
JOP20190215A1 (ar) * 2017-03-24 2019-09-19 Ionis Pharmaceuticals Inc مُعدّلات التعبير الوراثي عن pcsk9
WO2020109343A1 (en) 2018-11-29 2020-06-04 F. Hoffmann-La Roche Ag Combination therapy for treatment of macular degeneration
AU2020340987A1 (en) * 2019-09-03 2022-04-14 Arcturus Therapeutics, Inc. Asialoglycoprotein receptor mediated delivery of therapeutically active conjugates
IL297680A (en) * 2020-04-30 2022-12-01 Alnylam Pharmaceuticals Inc IRNA compounds complement factor b (cfb) and methods of using them
KR20240051221A (ko) 2021-09-02 2024-04-19 사일런스 테라퓨틱스 게엠베하 세포에서 보체 인자 b (cfb)의 발현을 억제하기 위한 핵산
CA3234636A1 (en) * 2021-10-29 2023-05-04 Alnylam Pharmaceuticals, Inc. Complement factor b (cfb) irna compositions and methods of use thereof

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