EA201691780A1 - Наноструктурированный песок, способ получения наноструктурированного песка, способ разделения смеси загрязняющее вещество-вода с помощью наноструктурированного песка и дополнительные применения - Google Patents

Наноструктурированный песок, способ получения наноструктурированного песка, способ разделения смеси загрязняющее вещество-вода с помощью наноструктурированного песка и дополнительные применения

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Publication number
EA201691780A1
EA201691780A1 EA201691780A EA201691780A EA201691780A1 EA 201691780 A1 EA201691780 A1 EA 201691780A1 EA 201691780 A EA201691780 A EA 201691780A EA 201691780 A EA201691780 A EA 201691780A EA 201691780 A1 EA201691780 A1 EA 201691780A1
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Prior art keywords
nanostructured sand
bbb
sand
nanostructured
antibody
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EA201691780A
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English (en)
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EA035480B1 (ru
Inventor
Даника Станимирович
Кристин Кеммерич
Арсалан С. Хаккани
Трайан Сули
Меди Арбаби-Гаруди
Бернар Масси
Рено Жильбер
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Нэшнл Рисеч Каунсил Оф Канада
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Publication of EA201691780A1 publication Critical patent/EA201691780A1/ru
Publication of EA035480B1 publication Critical patent/EA035480B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0058—Antibodies
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
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    • G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
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Abstract

Гематоэнцефалический барьер (ГЭБ) препятствует прохождению молекул массой более 500 Да из крови в мозг. Рецепторно-опосредованный трансцитоз (RMT) облегчает прохождение через ГЭБ специфических молекул, которые связывают рецепторы на эндотелиальных клетках мозга, образующих ГЭБ. Обнаружено антитело или его фрагмент, связывающее рецептор инсулиноподобного фактора роста 1, которое проходит ГЭБ посредством RMT. Антитело или фрагмент используют для доставки молекулы груза через ГЭБ, где молекула груза может представлять собой терапевтический или детектируемый агент. Антитело представляет собой верблюжий VHH, полученный иммунизацией ламы полипептидом IGF1R, состоящим из 933 аминокислот. Гуманизированные формы верблюжьего VHH также получены.
EA201691780A 2014-03-06 2014-12-04 Антитела, специфические к рецептору инсулиноподобного фактора роста 1 и их применения EA035480B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461948818P 2014-03-06 2014-03-06
PCT/CA2014/000861 WO2015131257A1 (en) 2014-03-06 2014-12-04 Insulin-like growth factor 1 receptor -specific antibodies and uses thereof

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EA201691780A1 true EA201691780A1 (ru) 2017-01-30
EA035480B1 EA035480B1 (ru) 2020-06-23

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US (1) US10112998B2 (ru)
EP (1) EP3114141B1 (ru)
JP (1) JP6541237B2 (ru)
KR (1) KR102355310B1 (ru)
CN (1) CN106559993B (ru)
AU (1) AU2014385800B2 (ru)
CA (1) CA2942154C (ru)
DK (1) DK3114141T3 (ru)
EA (1) EA035480B1 (ru)
IL (1) IL247606B (ru)
MX (1) MX2016011561A (ru)
NZ (1) NZ724868A (ru)
PE (1) PE20161311A1 (ru)
UA (1) UA121028C2 (ru)
WO (1) WO2015131257A1 (ru)
ZA (1) ZA201606211B (ru)

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CA2942154A1 (en) 2015-09-11
ZA201606211B (en) 2019-01-30
AU2014385800B2 (en) 2020-10-22
DK3114141T3 (da) 2020-08-10
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MX2016011561A (es) 2017-04-13
CA2942154C (en) 2023-06-27
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EP3114141B1 (en) 2020-05-06
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UA121028C2 (uk) 2020-03-25
IL247606A0 (en) 2016-11-30
BR112016020628A2 (pt) 2018-01-23
IL247606B (en) 2020-04-30
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EA035480B1 (ru) 2020-06-23

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