EA201592006A1 - Новые биспецифические связывающие молекулы с противоопухолевой активностью - Google Patents
Новые биспецифические связывающие молекулы с противоопухолевой активностьюInfo
- Publication number
- EA201592006A1 EA201592006A1 EA201592006A EA201592006A EA201592006A1 EA 201592006 A1 EA201592006 A1 EA 201592006A1 EA 201592006 A EA201592006 A EA 201592006A EA 201592006 A EA201592006 A EA 201592006A EA 201592006 A1 EA201592006 A1 EA 201592006A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- amino acid
- seq
- bispecific binding
- binding molecules
- tumor activity
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/10—Protein-tyrosine kinases (2.7.10)
- C12Y207/10002—Non-specific protein-tyrosine kinase (2.7.10.2), i.e. spleen tyrosine kinase
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2318/00—Antibody mimetics or scaffolds
- C07K2318/20—Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
Abstract
Изобретение относится к биспецифической связывающей молекуле, которая специфически связывается с (i) CD3 и (ii) поверхностным антигеном-мишенью на раковых клетках, где связывающая молекула включает в себя (a) антитело, специфически связывающееся с CD3, и (b) Fyn-SH3-производный полипептид, связывающийся с поверхностным антигеном-мишенью на раковых клетках, где указанный Fyn-SH3-производный полипептид состоит из аминокислотной последовательности SEQ ID NO: 1 при условии, что (i) по меньшей мере одна аминокислота в аминокислотных положениях с 10 по 19 в SEQ ID NO: 1 заменена, удалена или добавлена и (ii) по меньшей мере одна аминокислота в аминокислотных положениях с 29 по 36 в SEQ ID NO: 1 заменена, удалена или добавлена при условии, что указанный полипептид имеет по меньшей мере 85% идентичности последовательности с аминокислотной последовательностью SEQ ID NO: 1, где определение идентичности исключает аминокислотные положения с 12 по 17 и с 31 по 34 в SEQ ID NO: 1.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13164555 | 2013-04-19 | ||
| PCT/EP2014/054390 WO2014170063A1 (en) | 2013-04-19 | 2014-03-06 | Novel bispecific binding molecules with antitumoral activity |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EA201592006A1 true EA201592006A1 (ru) | 2016-03-31 |
Family
ID=48128216
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201592006A EA201592006A1 (ru) | 2013-04-19 | 2014-03-06 | Новые биспецифические связывающие молекулы с противоопухолевой активностью |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP2986630B1 (ru) |
| JP (2) | JP6694808B2 (ru) |
| KR (1) | KR20160002882A (ru) |
| CN (1) | CN105189544A (ru) |
| AU (1) | AU2014256037B2 (ru) |
| BR (1) | BR112015026143A2 (ru) |
| CA (1) | CA2908988A1 (ru) |
| CL (1) | CL2015003085A1 (ru) |
| EA (1) | EA201592006A1 (ru) |
| HK (1) | HK1214605A1 (ru) |
| MX (1) | MX2015014608A (ru) |
| PH (1) | PH12015502278A1 (ru) |
| SG (1) | SG11201508231UA (ru) |
| WO (1) | WO2014170063A1 (ru) |
| ZA (1) | ZA201507752B (ru) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012088266A2 (en) | 2010-12-22 | 2012-06-28 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3 |
| AR091424A1 (es) | 2012-06-13 | 2015-02-04 | Incyte Corp | Compuestos triciclicos sustituidos como inhibidores de receptores del factor de crecimiento del fibroplasto (fgfr) |
| TWI649318B (zh) | 2013-04-19 | 2019-02-01 | 英塞特控股公司 | 作為ｆｇｆｒ抑制劑之雙環雜環 |
| PE20161217A1 (es) | 2013-12-17 | 2016-11-16 | Genentech Inc | Anticuerpos anti-cd3 y metodos de uso |
| US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| MA41551A (fr) | 2015-02-20 | 2017-12-26 | Incyte Corp | Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4 |
| MX2017010673A (es) | 2015-02-20 | 2018-03-21 | Incyte Corp | Heterociclos biciclicos como inhibidores de receptores del factor de crecimiento fibroblastico (fgfr). |
| WO2016204966A1 (en) | 2015-06-16 | 2016-12-22 | Genentech, Inc. | Anti-cd3 antibodies and methods of use |
| FI126633B (en) | 2015-07-10 | 2017-03-15 | Next Biomed Therapies Oy | Method of Preparation of a Library comprising Recombinant Derivatives of the SH3 Domain of Nephrocystin (NPHP1) |
| KR20190074300A (ko) | 2016-11-15 | 2019-06-27 | 제넨테크, 인크. | 항-cd20/항-cd3 이중특이적 항체에 의한 치료를 위한 투약 |
| US10722589B2 (en) | 2017-04-03 | 2020-07-28 | Covagen Ag | FGFR3 binding molecules |
| SG11201909498XA (en) * | 2017-04-24 | 2019-11-28 | Glenmark Pharmaceuticals Sa | T cell redirecting bispecific antibodies for the treatment of egfr positive cancers |
| AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
| WO2019033050A1 (en) * | 2017-08-11 | 2019-02-14 | City Of Hope | BISPECIFIC MOLECULE FOR BINDING TO ANTIGEN |
| CA3072575A1 (en) | 2017-08-11 | 2019-02-14 | City Of Hope | Rna aptamers against transferrin receptor (tfr) |
| JP2020534811A (ja) * | 2017-09-08 | 2020-12-03 | マベリック セラピューティクス， インコーポレイテッドＭａｖｅｒｉｃｋ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． | Ｆｃ領域を含有する条件的に活性化された結合部分 |
| SG11202002089RA (en) | 2017-09-08 | 2020-04-29 | Maverick Therapeutics Inc | Constrained conditionally activated binding proteins |
| US20190153096A1 (en) | 2017-10-02 | 2019-05-23 | Covagen Ag | Cd3/cd33 bispecific binding molecules |
| US20190100587A1 (en) * | 2017-10-02 | 2019-04-04 | Covagen Ag | IgG1 Fc MUTANTS WITH ABLATED EFFECTOR FUNCTIONS |
| MA51793A (fr) | 2018-02-08 | 2020-12-16 | Hoffmann La Roche | Molécules bispécifiques de liaison à l'antigène et procédés d'utilisation |
| CA3099116A1 (en) | 2018-05-04 | 2019-11-07 | Incyte Corporation | Salts of an fgfr inhibitor |
| MA52494A (fr) | 2018-05-04 | 2021-03-10 | Incyte Corp | Formes solides d'un inhibiteur de fgfr et leurs procédés de préparation |
| US11628162B2 (en) | 2019-03-08 | 2023-04-18 | Incyte Corporation | Methods of treating cancer with an FGFR inhibitor |
| US11591329B2 (en) | 2019-07-09 | 2023-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| PE20221085A1 (es) | 2019-10-14 | 2022-07-05 | Incyte Corp | Heterociclos biciclicos como inhibidores de fgfr |
| US11566028B2 (en) | 2019-10-16 | 2023-01-31 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| US11407750B2 (en) | 2019-12-04 | 2022-08-09 | Incyte Corporation | Derivatives of an FGFR inhibitor |
| JP2023505258A (ja) | 2019-12-04 | 2023-02-08 | インサイト・コーポレイション | Ｆｇｆｒ阻害剤としての三環式複素環 |
| AU2020401755A1 (en) | 2019-12-11 | 2022-08-04 | Cilag Gmbh International | Multispecific binding molecules comprising LTBR and EDB binding domains and uses thereof |
| IL293423A (en) | 2019-12-13 | 2022-07-01 | Genentech Inc | Anti-ly6g6d antibodies and methods of use |
| AR126102A1 (es) | 2021-06-09 | 2023-09-13 | Incyte Corp | Heterociclos tricíclicos como inhibidores de fgfr |
| WO2023044483A2 (en) | 2021-09-20 | 2023-03-23 | Voyager Therapeutics, Inc. | Compositions and methods for the treatment of her2 positive cancer |
| WO2023092004A1 (en) | 2021-11-17 | 2023-05-25 | Voyager Therapeutics, Inc. | Compositions and methods for the treatment of tau-related disorders |
| WO2023201291A1 (en) | 2022-04-13 | 2023-10-19 | Genentech, Inc. | Pharmaceutical compositions of mosunetuzumab and methods of use |
| WO2023220695A2 (en) | 2022-05-13 | 2023-11-16 | Voyager Therapeutics, Inc. | Compositions and methods for the treatment of her2 positive cancer |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1892248A1 (en) * | 2006-08-21 | 2008-02-27 | Eidgenössische Technische Hochschule Zürich | Specific and high affinity binding proteins comprising modified SH3 domains of FYN kinase |
| AU2010288542B2 (en) * | 2009-08-27 | 2014-05-22 | Covagen Ag | IL-17 binding compounds and medical uses thereof |
| WO2011116387A1 (en) * | 2010-03-19 | 2011-09-22 | Tetragenetics, Inc. | Production of aglycosylated monoclonal antibodies in ciliates |
| CA2800785C (en) * | 2010-05-27 | 2019-09-24 | Genmab A/S | Monoclonal antibodies against her2 |
-
2014
- 2014-03-06 AU AU2014256037A patent/AU2014256037B2/en not_active Ceased
- 2014-03-06 MX MX2015014608A patent/MX2015014608A/es unknown
- 2014-03-06 SG SG11201508231UA patent/SG11201508231UA/en unknown
- 2014-03-06 EA EA201592006A patent/EA201592006A1/ru unknown
- 2014-03-06 WO PCT/EP2014/054390 patent/WO2014170063A1/en active Application Filing
- 2014-03-06 KR KR1020157031680A patent/KR20160002882A/ko not_active Application Discontinuation
- 2014-03-06 CA CA2908988A patent/CA2908988A1/en not_active Abandoned
- 2014-03-06 CN CN201480022196.2A patent/CN105189544A/zh active Pending
- 2014-03-06 BR BR112015026143A patent/BR112015026143A2/pt not_active IP Right Cessation
- 2014-03-06 EP EP14710220.6A patent/EP2986630B1/en active Active
- 2014-03-06 JP JP2016508054A patent/JP6694808B2/ja not_active Expired - Fee Related
-
2015
- 2015-09-30 PH PH12015502278A patent/PH12015502278A1/en unknown
- 2015-10-16 ZA ZA2015/07752A patent/ZA201507752B/en unknown
- 2015-10-19 CL CL2015003085A patent/CL2015003085A1/es unknown
-
2016
- 2016-03-01 HK HK16102370.8A patent/HK1214605A1/zh unknown
-
2019
- 2019-01-30 JP JP2019013831A patent/JP2019106997A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2014256037A1 (en) | 2015-10-29 |
| HK1214605A1 (zh) | 2016-07-29 |
| JP2016516789A (ja) | 2016-06-09 |
| JP6694808B2 (ja) | 2020-05-20 |
| ZA201507752B (en) | 2017-03-29 |
| CN105189544A (zh) | 2015-12-23 |
| CA2908988A1 (en) | 2014-10-23 |
| WO2014170063A1 (en) | 2014-10-23 |
| PH12015502278A1 (en) | 2016-02-01 |
| KR20160002882A (ko) | 2016-01-08 |
| AU2014256037B2 (en) | 2017-09-21 |
| BR112015026143A2 (pt) | 2017-10-17 |
| EP2986630B1 (en) | 2018-08-15 |
| JP2019106997A (ja) | 2019-07-04 |
| MX2015014608A (es) | 2016-03-03 |
| CL2015003085A1 (es) | 2016-06-03 |
| EP2986630A1 (en) | 2016-02-24 |
| SG11201508231UA (en) | 2015-11-27 |
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