EA201691136A1 - Производное на основе 1,2-нафтохинона и способ его получения - Google Patents

Производное на основе 1,2-нафтохинона и способ его получения

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Publication number
EA201691136A1
EA201691136A1 EA201691136A EA201691136A EA201691136A1 EA 201691136 A1 EA201691136 A1 EA 201691136A1 EA 201691136 A EA201691136 A EA 201691136A EA 201691136 A EA201691136 A EA 201691136A EA 201691136 A1 EA201691136 A1 EA 201691136A1
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Eurasian Patent Office
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naftohinon
derivative
obtaining
basis
pharmaceutically acceptable
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EA201691136A
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English (en)
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EA035576B1 (ru
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Вхее Сеонг Ли
Ми Дзунг Ли
Бо Дзунг Ким
Тае Чеул Рох
Сеунг Хоон Ли
Киу Дае Ли
Ю-Хуи Ли
Тае Хван Квак
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КейТи ЭНД Джи ЛАЙФ САЙЕНСИЗ КОРПОРЕЙШН
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Publication of EA201691136A1 publication Critical patent/EA201691136A1/ru
Publication of EA035576B1 publication Critical patent/EA035576B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
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    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

Настоящее изобретение раскрывает соединение, представленное формулой (1), или его фармацевтически приемлемую соль, гидрат, сольват, пролекарство, таутомер, энантиомер или фармацевтически приемлемый диастереомер, способ их получения и содержащую их фармацевтическую композицию, которая обладает эффектами лечения или предотвращения метаболических синдромов, где R-R, X-Xи n являются такими же, как определено в п.1.
EA201691136A 2013-12-30 2014-12-30 Производное на основе 1,2-нафтохинона и способ его получения EA035576B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20130166585 2013-12-30
PCT/KR2014/013040 WO2015102371A1 (ko) 2013-12-30 2014-12-30 1,2 나프토퀴논 유도체 및 이의 제조방법

Publications (2)

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EA201691136A1 true EA201691136A1 (ru) 2016-10-31
EA035576B1 EA035576B1 (ru) 2020-07-09

Family

ID=53493653

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EA201691136A EA035576B1 (ru) 2013-12-30 2014-12-30 Производное на основе 1,2-нафтохинона и способ его получения

Country Status (12)

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US (2) US9975883B2 (ru)
EP (1) EP3091003A4 (ru)
JP (1) JP6680679B2 (ru)
KR (1) KR101739361B1 (ru)
CN (2) CN112300078A (ru)
AU (1) AU2014374603B2 (ru)
CA (1) CA2935317C (ru)
CL (1) CL2016001587A1 (ru)
EA (1) EA035576B1 (ru)
MX (1) MX2016008665A (ru)
WO (1) WO2015102371A1 (ru)
ZA (1) ZA201604328B (ru)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112300078A (zh) * 2013-12-30 2021-02-02 永进药品工业株式会社 1,2-萘醌的衍生物及其制备方法
KR102005068B1 (ko) * 2015-03-27 2019-07-30 주식회사 휴엔 1,2 나프토퀴논 유도체 및 이의 제조방법
CN105541732B (zh) * 2015-12-18 2018-01-30 新乡医学院 一种β‑拉帕醌衍生物及其制备方法和医药用途
JP2018083799A (ja) 2016-11-15 2018-05-31 バイオエレクトロン テクノロジー コーポレイション ２−置換アミノ−ナフト［１，２−ｄ］イミダゾール−５−オン化合物またはその製薬学上許容される塩
WO2019198977A1 (ko) 2018-04-09 2019-10-17 영진약품 주식회사 1,2-나프토퀴논 유도체 화합물을 포함하는 고형암 또는 혈액암의 예방 또는 치료용 약학 조성물
US11717511B2 (en) 2018-04-09 2023-08-08 Huen Co., Ltd. Pharmaceutical composition comprising derivative compound of 1,2-naphthoquinone for preventing or treating solid cancer or blood cancer
WO2020063824A1 (zh) * 2018-09-29 2020-04-02 江苏亚虹医药科技有限公司 硝羟喹啉前药及其用途
CN111153938A (zh) * 2018-11-08 2020-05-15 香港理工大学深圳研究院 手性单齿苯并咪唑-吲哚膦配体化合物及其制备方法和应用
KR102201768B1 (ko) * 2019-02-28 2021-01-12 주식회사 엘마이토테라퓨틱스 벤조인다졸론 화합물 및 그 용도
KR102247694B1 (ko) 2019-05-31 2021-05-03 주식회사 엘마이토테라퓨틱스 나프토퀴논 또는 벤조인다졸 화합물을 유효성분으로 포함하는 염증성 질환 치료용 약학적 조성물
IL299755A (en) 2020-07-10 2023-03-01 Nadianbio Ltd A pharmaceutical preparation for the prevention or treatment of cancer that contains a naphthoquinone-based compound and inhibits an immune checkpoint as active ingredients
EP4212530A1 (en) * 2020-08-17 2023-07-19 Lmito Therapeutics Inc. Imidazolquinoline or benzoindazolone compound and intermediate for preparing same

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4815786B2 (ja) * 2004-11-08 2011-11-16 ソニー株式会社 表示素子用有機材料および表示素子
EP1994168A4 (en) 2006-02-15 2009-05-27 Md Bioalpha Co Ltd METHOD OF CONTROLLING NAD (P) / NAD (P) H RATIO BY OXIDOREDUCTASE
KR20080047957A (ko) * 2006-11-27 2008-05-30 주식회사 엠디바이오알파 고혈압의 치료 및 예방을 위한 약제 조성물
WO2008066300A1 (en) * 2006-11-27 2008-06-05 Mazence Inc. Naphthoquinone-based pharmaceutical composition for treatment or prevention of diseases involving obesity, diabetes, metabolic syndrome, neuro-degenerative diseases and mitochondria dysfunction diseases
CN112300078A (zh) * 2013-12-30 2021-02-02 永进药品工业株式会社 1,2-萘醌的衍生物及其制备方法

Also Published As

Publication number Publication date
WO2015102371A1 (ko) 2015-07-09
EP3091003A4 (en) 2017-06-28
KR101739361B1 (ko) 2017-05-25
CA2935317A1 (en) 2015-07-09
CL2016001587A1 (es) 2016-12-02
US10766882B2 (en) 2020-09-08
KR20150080423A (ko) 2015-07-09
CN112300078A (zh) 2021-02-02
EA035576B1 (ru) 2020-07-09
ZA201604328B (en) 2018-08-29
EP3091003A1 (en) 2016-11-09
CN105992759B (zh) 2020-10-30
CN105992759A (zh) 2016-10-05
JP6680679B2 (ja) 2020-04-15
US20160376258A1 (en) 2016-12-29
US20180258079A1 (en) 2018-09-13
US9975883B2 (en) 2018-05-22
AU2014374603B2 (en) 2019-06-06
BR112016015290A2 (pt) 2017-08-08
MX2016008665A (es) 2017-02-15
CA2935317C (en) 2022-11-22
JP2017502976A (ja) 2017-01-26
AU2014374603A1 (en) 2016-06-30

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