MX2015012111A - Moduladores de ship1 y métodos relacionados con éstos. - Google Patents

Moduladores de ship1 y métodos relacionados con éstos.

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Publication number
MX2015012111A
MX2015012111A MX2015012111A MX2015012111A MX2015012111A MX 2015012111 A MX2015012111 A MX 2015012111A MX 2015012111 A MX2015012111 A MX 2015012111A MX 2015012111 A MX2015012111 A MX 2015012111A MX 2015012111 A MX2015012111 A MX 2015012111A
Authority
MX
Mexico
Prior art keywords
compounds
ship1
methods related
modulators
ship1 modulators
Prior art date
Application number
MX2015012111A
Other languages
English (en)
Inventor
David Bogucki
Jeffery R Raymond
Lloyd F Mackenzie
Thomas B Macrury
Jeremy D Pettigrew
Curtis Harwig
Original Assignee
Aquinox Pharmaceuticals Canada Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aquinox Pharmaceuticals Canada Inc filed Critical Aquinox Pharmaceuticals Canada Inc
Publication of MX2015012111A publication Critical patent/MX2015012111A/es

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    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
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    • C07C2601/14—The ring being saturated
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    • C07C2602/14—All rings being cycloaliphatic
    • C07C2602/24—All rings being cycloaliphatic the ring system containing nine carbon atoms, e.g. perhydroindane

Abstract

Compuestos de fórmula (II): (Ver formula) en donde A, R1, R2, R5 y R13 se describen en este documento, o un estereoisómero, enantiómero o tautómero de los mismos o mezclas de los mismos, o una sal o solvato farmaceuticamente aceptables de los mismos, se describen en este documento, asi como otros compuestos; estos compuestos tienen actividad como moduladores del SHIP1 y así pueden ser útiles en el tratamiento de una variedad de enfermedades, trastornos o afecciones que se beneficiarían de la modulación de SHIP1; también se describen composiciones que comprenden un compuesto de la invención, así como métodos de modulación de SHIP1 por administración de dichos compuestos a un animal en necesidad de los mismos.
MX2015012111A 2013-03-14 2014-02-27 Moduladores de ship1 y métodos relacionados con éstos. MX2015012111A (es)

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