EA201592212A8 - Кристаллические полиморфные формы свободного основания 2-гидрокси-6-((2-(1-изопропил-1н-пиразол-5-ил)пиридин-3-ил)метокси)бензальдегида - Google Patents

Кристаллические полиморфные формы свободного основания 2-гидрокси-6-((2-(1-изопропил-1н-пиразол-5-ил)пиридин-3-ил)метокси)бензальдегида

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Publication number
EA201592212A8
EA201592212A8 EA201592212A EA201592212A EA201592212A8 EA 201592212 A8 EA201592212 A8 EA 201592212A8 EA 201592212 A EA201592212 A EA 201592212A EA 201592212 A EA201592212 A EA 201592212A EA 201592212 A8 EA201592212 A8 EA 201592212A8
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EA
Eurasian Patent Office
Prior art keywords
pyrazol
benzaldehyde
isopropyl
hydroxy
methox
Prior art date
Application number
EA201592212A
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English (en)
Other versions
EA201592212A1 (ru
EA028529B1 (ru
Inventor
Чжэ Ли
Стефан Д. Пэрент
Тревис Хьюстон
Original Assignee
Глобал Блад Терапьютикс, Инк.
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53774359&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201592212(A8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Глобал Блад Терапьютикс, Инк. filed Critical Глобал Блад Терапьютикс, Инк.
Publication of EA201592212A1 publication Critical patent/EA201592212A1/ru
Publication of EA201592212A8 publication Critical patent/EA201592212A8/ru
Publication of EA028529B1 publication Critical patent/EA028529B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

В настоящей заявке раскрыты формы кристаллического десольвата свободного основания 2-гидрокси-6-((2-(1-изопропил-1Н-пиразол-5-ил)пиридин-3-ил)метокси)бензальдегида (или Соединения 1), такие как форма I, форма II и вещество N свободного основания. Также раскрыты кристаллические сольваты свободного основания 2-гидрокси-6-((2-(1-изопропил-1Н-пиразол-5-ил)пиридин-3-ил)метокси)бензальдегида (или Соединения 1).
EA201592212A 2014-02-07 2015-02-05 Кристаллические полиморфные формы свободного основания 2-гидрокси-6-((2-(1-изопропил-1н-пиразол-5-ил)пиридин-3-ил)метокси)бензальдегида EA028529B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461937404P 2014-02-07 2014-02-07
US201461937393P 2014-02-07 2014-02-07
PCT/US2015/014589 WO2015120133A1 (en) 2014-02-07 2015-02-05 Crystalline polymorphs of the free base of 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)pyridin-3-yl)methoxy)benzaldehyde

Publications (3)

Publication Number Publication Date
EA201592212A1 EA201592212A1 (ru) 2016-05-31
EA201592212A8 true EA201592212A8 (ru) 2016-07-29
EA028529B1 EA028529B1 (ru) 2017-11-30

Family

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EA201592212A EA028529B1 (ru) 2014-02-07 2015-02-05 Кристаллические полиморфные формы свободного основания 2-гидрокси-6-((2-(1-изопропил-1н-пиразол-5-ил)пиридин-3-ил)метокси)бензальдегида

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US (6) US9447071B2 (ru)
EP (2) EP3102208B1 (ru)
JP (4) JP6809681B2 (ru)
KR (2) KR102345380B1 (ru)
CN (4) CN114181194A (ru)
AP (1) AP2016009261A0 (ru)
AU (3) AU2015214182B2 (ru)
BR (1) BR112015032160B1 (ru)
CA (1) CA2916564C (ru)
CY (1) CY1124097T1 (ru)
DK (1) DK3102208T3 (ru)
EA (1) EA028529B1 (ru)
ES (1) ES2860648T3 (ru)
HR (1) HRP20210388T1 (ru)
HU (1) HUE053706T2 (ru)
IL (2) IL243214B (ru)
LT (1) LT3102208T (ru)
MX (2) MX361810B (ru)
MY (1) MY189995A (ru)
NZ (1) NZ715029A (ru)
PE (2) PE20201444A1 (ru)
PL (1) PL3102208T3 (ru)
PT (1) PT3102208T (ru)
RS (1) RS61653B1 (ru)
SA (1) SA516370358B1 (ru)
SG (4) SG10201804139VA (ru)
SI (1) SI3102208T1 (ru)
TW (4) TWI799115B (ru)
WO (1) WO2015120133A1 (ru)

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