EA201590504A1 - Индолкарбоксамидные производные и их применение - Google Patents
Индолкарбоксамидные производные и их применениеInfo
- Publication number
- EA201590504A1 EA201590504A1 EA201590504A EA201590504A EA201590504A1 EA 201590504 A1 EA201590504 A1 EA 201590504A1 EA 201590504 A EA201590504 A EA 201590504A EA 201590504 A EA201590504 A EA 201590504A EA 201590504 A1 EA201590504 A1 EA 201590504A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- indolkarboxamid
- derivatives
- application
- present
- irreplaceable
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
Abstract
Настоящее изобретение относится к соединениям формулы (I), для которых показано, что они являются пригодными в лечении заболевания, расстройства или синдрома, которые опосредованы транспортировкой незаменимых молекул в mmpL3 пути: (I) где R, R, R, R, Rи Rопределены в настоящем изобретении.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261698033P | 2012-09-07 | 2012-09-07 | |
PCT/IB2013/058318 WO2014037900A1 (en) | 2012-09-07 | 2013-09-05 | Indole carboxamide derivatives and uses thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201590504A1 true EA201590504A1 (ru) | 2015-07-30 |
EA028093B1 EA028093B1 (ru) | 2017-10-31 |
Family
ID=49585451
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201590504A EA028093B1 (ru) | 2012-09-07 | 2013-09-05 | Индолкарбоксамидные производные и их применение |
Country Status (11)
Country | Link |
---|---|
US (3) | US9447039B2 (ru) |
EP (1) | EP2892880B1 (ru) |
JP (1) | JP6223452B2 (ru) |
KR (1) | KR20150048759A (ru) |
CN (1) | CN104603106B (ru) |
BR (1) | BR112015004666B1 (ru) |
CA (1) | CA2881351A1 (ru) |
EA (1) | EA028093B1 (ru) |
ES (1) | ES2660210T3 (ru) |
IN (1) | IN2015DN01163A (ru) |
WO (1) | WO2014037900A1 (ru) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2944240A1 (en) | 2014-04-04 | 2015-10-08 | Iomet Pharma Ltd | Indole derivatives as ido/tdo inhibitors |
WO2015164482A1 (en) * | 2014-04-22 | 2015-10-29 | The Johns Hopkins University | Inhibitors of drug-resistant mycobacterium tuberculosis |
AR102426A1 (es) * | 2014-10-24 | 2017-03-01 | Bristol Myers Squibb Co | Compuestos de indolcarboxamida como inhibidores de btk |
CN107298650B (zh) * | 2016-04-15 | 2022-11-15 | 浙江中科创越药业有限公司 | 杂环羧酸酰胺配体及其在铜催化芳基卤代物偶联反应中的用途 |
CN110305798B (zh) * | 2016-06-15 | 2021-11-19 | 中国医学科学院医药生物技术研究所 | 一株曲霉菌的用途及由该曲霉菌制备的化合物及其用途 |
US10383848B2 (en) * | 2016-08-04 | 2019-08-20 | Creighton University | Indole-based therapeutics |
US10858319B2 (en) | 2016-10-03 | 2020-12-08 | Iomet Pharma Ltd. | Indole derivatives for use in medicine |
US11938114B2 (en) | 2017-03-10 | 2024-03-26 | Rutgers, The State University Of New Jersey | Bacterial efflux pump inhibitors |
WO2018165612A1 (en) | 2017-03-10 | 2018-09-13 | Rutgers, The State University Of New Jersey | Bacterial efflux pump inhibitors |
US11826357B2 (en) | 2017-05-26 | 2023-11-28 | Rutgers, The State University Of New Jersey | Bacterial efflux pump inhibitors |
WO2019005841A1 (en) * | 2017-06-26 | 2019-01-03 | Rutgers, The State University Of New Jersey | THERAPEUTIC COMPOUNDS AND METHODS FOR TREATING INFECTION |
US11718633B2 (en) | 2018-05-17 | 2023-08-08 | Council Of Scientific And Industrial Research | Indole compounds, process for the preparation and use thereof |
KR102219563B1 (ko) * | 2019-02-15 | 2021-02-24 | 에스티팜 주식회사 | 페나진 유도체 제조를 위한 중간체 및 그의 제조방법 |
CN110577483B (zh) * | 2019-09-26 | 2020-05-12 | 海南医学院 | 一种3,3-二取代-2-吲哚酮的绿色合成方法 |
WO2021062318A1 (en) * | 2019-09-26 | 2021-04-01 | The Global Alliance For Tb Drug Development, Inc. | Thiazole carboxamide compounds and use thereof for the treatment of mycobacterial infections |
CN114746090A (zh) * | 2019-09-26 | 2022-07-12 | 结核病药物开发全球联盟公司 | 用于治疗分枝杆菌感染的氮杂吲哚甲酰胺化合物 |
BR112022005723A2 (pt) * | 2019-09-26 | 2022-08-23 | The Global Alliance For Tb Drug Dev Inc | Compostos de indol carboxamida e seu uso para o tratamento de infecções micobacterianas |
RU2767542C1 (ru) * | 2021-05-24 | 2022-03-17 | Федеральное государственное автономное образовательное учреждение высшего образования "Пермский государственный национальный исследовательский университет" (ПГНИУ) | Противотуберкулезное средство на основе 4-((гет)ароил)-3- гидрокси-1-(2-гидроксифенил)-5-(фенилтио)-1,5-дигидро-2Н-пиррол-2-онов |
CN115583908A (zh) * | 2021-07-05 | 2023-01-10 | 西北农林科技大学 | 一种吲哚甲酰胺类化合物及其制备方法和用途 |
US20230039586A1 (en) * | 2021-07-12 | 2023-02-09 | Nido Biosciences, Inc. | Bicyclic compounds as androgen receptor modulators |
Family Cites Families (19)
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US883049A (en) * | 1907-09-12 | 1908-03-24 | John W Piver | Tongue-and-groove joint for flooring. |
FR2705095B1 (fr) * | 1993-05-12 | 1995-06-23 | Adir | Nouveaux indoles substitués, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |
HU227197B1 (en) * | 2000-10-24 | 2010-10-28 | Richter Gedeon Nyrt | Nmda receptor antagonist carboxylic acid amide derivatives and pharmaceutical compositions containing them |
WO2003000657A1 (fr) | 2001-06-20 | 2003-01-03 | Daiichi Pharmaceutical Co., Ltd. | Derives de diamine |
JP4623962B2 (ja) | 2001-10-22 | 2011-02-02 | ザ・リサーチ・ファウンデーション・オブ・ステイト・ユニバーシティ・オブ・ニューヨーク | タンパク質キナーゼおよびホスファターゼ阻害剤、それらを設計する方法、ならびにそれらを使用する方法 |
CN1315806C (zh) | 2001-12-04 | 2007-05-16 | 霍夫曼·拉罗奇有限公司 | 取代的2-氨基-环烷烃甲酰胺和它们作为半胱氨酸蛋白酶抑制剂的用途 |
US6759428B2 (en) | 2001-12-04 | 2004-07-06 | Roche Palo Alto Llc | Indole nitriles |
WO2004078163A2 (en) | 2003-02-28 | 2004-09-16 | Transform Pharmaceuticals, Inc. | Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen |
AU2003227360A1 (en) * | 2002-04-25 | 2003-11-10 | Yamanouchi Pharmaceutical Co., Ltd. | Novel amide derivatives or salts thereof |
GB0428173D0 (en) * | 2004-12-23 | 2005-01-26 | Astrazeneca Ab | Compounds |
US8691859B2 (en) * | 2005-08-12 | 2014-04-08 | The United States Of America As Represented By The Secretary Of The Army | Broad spectrum antibacterial compounds |
JP5111491B2 (ja) | 2006-04-04 | 2013-01-09 | フィブロジェン, インコーポレイテッド | ピロロ−およびピラゾロ−ピリミジン化合物、およびそれらの使用方法 |
WO2009063495A2 (en) | 2007-09-20 | 2009-05-22 | Cadila Healthcare Limited | Substituted indole and its derivatives as cannabinoid modulators |
JP5487214B2 (ja) * | 2008-12-19 | 2014-05-07 | ブリストル−マイヤーズ スクイブ カンパニー | キナーゼ阻害剤として有用なカルバゾールカルボキシアミド化合物 |
CN104856991A (zh) | 2009-02-27 | 2015-08-26 | 西佳技术公司 | 用于治疗和预防登革热病毒感染的噻吩并吡啶衍生物 |
CN102596959A (zh) | 2009-07-31 | 2012-07-18 | 拜奥克里斯特制药公司 | 吡咯并[1,2-b]哒嗪衍生物作为janus激酶抑制剂 |
CA2781888C (en) | 2009-12-11 | 2019-06-18 | Nono Inc. | Agents and methods for treating ischemic and other diseases |
JP2012107001A (ja) * | 2010-10-22 | 2012-06-07 | Shionogi & Co Ltd | インドールアミド化合物を含有する医薬 |
US9200046B2 (en) * | 2011-06-29 | 2015-12-01 | Cornell University | Reporter system for high throughput screening of compounds and uses thereof |
-
2013
- 2013-09-05 BR BR112015004666-5A patent/BR112015004666B1/pt active IP Right Grant
- 2013-09-05 WO PCT/IB2013/058318 patent/WO2014037900A1/en active Application Filing
- 2013-09-05 CA CA2881351A patent/CA2881351A1/en not_active Abandoned
- 2013-09-05 EP EP13792084.9A patent/EP2892880B1/en active Active
- 2013-09-05 ES ES13792084.9T patent/ES2660210T3/es active Active
- 2013-09-05 KR KR1020157005663A patent/KR20150048759A/ko not_active Application Discontinuation
- 2013-09-05 JP JP2015530536A patent/JP6223452B2/ja active Active
- 2013-09-05 EA EA201590504A patent/EA028093B1/ru not_active IP Right Cessation
- 2013-09-05 US US14/420,074 patent/US9447039B2/en active Active
- 2013-09-05 CN CN201380046508.9A patent/CN104603106B/zh active Active
-
2015
- 2015-02-12 IN IN1163DEN2015 patent/IN2015DN01163A/en unknown
-
2016
- 2016-08-19 US US15/242,160 patent/US20160355477A1/en not_active Abandoned
-
2020
- 2020-06-12 US US16/899,931 patent/US20210032202A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
BR112015004666A2 (pt) | 2017-07-04 |
JP6223452B2 (ja) | 2017-11-01 |
EP2892880A1 (en) | 2015-07-15 |
EA028093B1 (ru) | 2017-10-31 |
WO2014037900A1 (en) | 2014-03-13 |
EP2892880B1 (en) | 2017-11-22 |
ES2660210T3 (es) | 2018-03-21 |
IN2015DN01163A (ru) | 2015-06-26 |
BR112015004666B1 (pt) | 2022-04-26 |
AU2013311235B2 (en) | 2016-03-24 |
AU2013311235A1 (en) | 2015-02-26 |
KR20150048759A (ko) | 2015-05-07 |
CN104603106A (zh) | 2015-05-06 |
US20150175539A1 (en) | 2015-06-25 |
US20210032202A1 (en) | 2021-02-04 |
CN104603106B (zh) | 2017-05-10 |
CA2881351A1 (en) | 2014-03-13 |
JP2015527388A (ja) | 2015-09-17 |
US9447039B2 (en) | 2016-09-20 |
US20160355477A1 (en) | 2016-12-08 |
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MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG TJ TM |