EA201692316A1 - Производные холана для применения при лечении и/или профилактике fxr и tgr5/gpbar1-опосредованных заболеваний - Google Patents

Производные холана для применения при лечении и/или профилактике fxr и tgr5/gpbar1-опосредованных заболеваний

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Publication number
EA201692316A1
EA201692316A1 EA201692316A EA201692316A EA201692316A1 EA 201692316 A1 EA201692316 A1 EA 201692316A1 EA 201692316 A EA201692316 A EA 201692316A EA 201692316 A EA201692316 A EA 201692316A EA 201692316 A1 EA201692316 A1 EA 201692316A1
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EA
Eurasian Patent Office
Prior art keywords
gpbar1
tgr5
fxr
prevention
treatment
Prior art date
Application number
EA201692316A
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English (en)
Other versions
EA032820B1 (ru
Inventor
Анджела Цампелла
Стефано Фьоруччи
Original Assignee
Бар Фармасьютикалз С.Р.Л.
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Application filed by Бар Фармасьютикалз С.Р.Л. filed Critical Бар Фармасьютикалз С.Р.Л.
Publication of EA201692316A1 publication Critical patent/EA201692316A1/ru
Publication of EA032820B1 publication Critical patent/EA032820B1/ru

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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
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    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
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    • C07—ORGANIC CHEMISTRY
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    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

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Abstract

Изобретение относится к соединениям, имеющим каркасную структуру холана формулы (I), указанным соединениям для применения при лечении и/или профилактике FXR- и TGR5/GPBAR1-опосредованных заболеваний.
EA201692316A 2014-05-29 2015-05-28 Производные холана для применения при лечении и/или профилактике fxr- и tgr5/gpbar1-опосредованных заболеваний EA032820B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITFI20140130 2014-05-29
PCT/EP2015/061802 WO2015181275A1 (en) 2014-05-29 2015-05-28 Cholane derivatives for use in the treatment and/or prevention of fxr and tgr5/gpbar1 mediated diseases

Publications (2)

Publication Number Publication Date
EA201692316A1 true EA201692316A1 (ru) 2017-03-31
EA032820B1 EA032820B1 (ru) 2019-07-31

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EA201692316A EA032820B1 (ru) 2014-05-29 2015-05-28 Производные холана для применения при лечении и/или профилактике fxr- и tgr5/gpbar1-опосредованных заболеваний

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US (2) US10407462B2 (ru)
EP (2) EP3149019B1 (ru)
JP (1) JP6820253B2 (ru)
KR (1) KR102491556B1 (ru)
CN (2) CN110003301B (ru)
AU (1) AU2015265893B2 (ru)
CA (1) CA2948585C (ru)
CY (1) CY1122631T1 (ru)
DK (2) DK3626725T3 (ru)
EA (1) EA032820B1 (ru)
ES (2) ES2938874T3 (ru)
FI (1) FI3626725T3 (ru)
HR (2) HRP20230170T1 (ru)
HU (2) HUE048351T2 (ru)
LT (2) LT3626725T (ru)
MA (1) MA39881B1 (ru)
MX (2) MX2020004024A (ru)
PH (1) PH12016502327A1 (ru)
PL (2) PL3626725T3 (ru)
PT (2) PT3626725T (ru)
RS (2) RS59910B1 (ru)
SG (2) SG10201809362RA (ru)
SI (2) SI3149019T1 (ru)
WO (1) WO2015181275A1 (ru)

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