EA201491227A1 - Новые производные морфолинила, подходящие для применения в качестве ингибиторов mogat-2 - Google Patents

Новые производные морфолинила, подходящие для применения в качестве ингибиторов mogat-2

Info

Publication number
EA201491227A1
EA201491227A1 EA201491227A EA201491227A EA201491227A1 EA 201491227 A1 EA201491227 A1 EA 201491227A1 EA 201491227 A EA201491227 A EA 201491227A EA 201491227 A EA201491227 A EA 201491227A EA 201491227 A1 EA201491227 A1 EA 201491227A1
Authority
EA
Eurasian Patent Office
Prior art keywords
morfolinil
mogat
inhibitors
new
derivatives suitable
Prior art date
Application number
EA201491227A
Other languages
English (en)
Other versions
EA024182B1 (ru
Inventor
Мария Росарио Гонсалес-Гарсиа
Мария Кармен Фернандес
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48905712&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201491227(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA201491227A1 publication Critical patent/EA201491227A1/ru
Publication of EA024182B1 publication Critical patent/EA024182B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
    • C07C57/145—Maleic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms

Abstract

В изобретении предложены соединения формулы Iили их фармацевтически приемлемые соли, способы лечения гипертриглицеридемии с применением соединений и способы получения соединений.
EA201491227A 2012-01-31 2013-01-24 Новые производные морфолинила, подходящие для применения в качестве ингибиторов mogat-2 EA024182B1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP12382037 2012-01-31
US201261617093P 2012-03-29 2012-03-29
EP12382433 2012-11-06
PCT/US2013/022828 WO2013116065A1 (en) 2012-01-31 2013-01-24 Novel morpholinyl derivatives useful as mogat-2 inhibitors

Publications (2)

Publication Number Publication Date
EA201491227A1 true EA201491227A1 (ru) 2015-01-30
EA024182B1 EA024182B1 (ru) 2016-08-31

Family

ID=48905712

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201491227A EA024182B1 (ru) 2012-01-31 2013-01-24 Новые производные морфолинила, подходящие для применения в качестве ингибиторов mogat-2

Country Status (24)

Country Link
US (1) US8993568B2 (ru)
EP (1) EP2809661B1 (ru)
JP (1) JP5852269B2 (ru)
KR (1) KR20140107641A (ru)
CN (1) CN104080777B (ru)
AP (1) AP2014007793A0 (ru)
AU (1) AU2013215549B2 (ru)
BR (1) BR112014018712A8 (ru)
CA (1) CA2859992A1 (ru)
CL (1) CL2014001862A1 (ru)
CO (1) CO7020914A2 (ru)
CR (1) CR20140325A (ru)
DO (1) DOP2014000177A (ru)
EA (1) EA024182B1 (ru)
ES (1) ES2571577T3 (ru)
GT (1) GT201400169A (ru)
HK (1) HK1199024A1 (ru)
IL (1) IL233542A0 (ru)
MX (1) MX2014008604A (ru)
PE (1) PE20141789A1 (ru)
PH (1) PH12014501712B1 (ru)
SG (1) SG11201404508XA (ru)
WO (1) WO2013116065A1 (ru)
ZA (1) ZA201405227B (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013112323A1 (en) 2012-01-23 2013-08-01 Eli Lilly And Company Phenyl methanesulfonamide derivatives useful as mgat - 2 inhibitors
CN104080777B (zh) 2012-01-31 2015-12-09 伊莱利利公司 用作mogat-2抑制剂的吗啉基衍生物
AR089771A1 (es) 2012-01-31 2014-09-17 Lilly Co Eli Derivados de bencil sulfonamida utiles como inhibidores de mogat-2
EA201590696A1 (ru) 2012-11-06 2015-08-31 Эли Лилли Энд Компани Новые бензилсульфонамидные соединения, подходящие в качестве ингибиторов mogat-2
US10335401B2 (en) 2015-12-21 2019-07-02 Shionogi & Co., Ltd. Non-aromatic heterocyclic derivative having MGAT2 inhibitory activity
TWI782056B (zh) 2017-07-14 2022-11-01 日商鹽野義製藥股份有限公司 具有ｍｇａｔ２抑制活性的縮合環衍生物
MX2021008050A (es) 2019-01-11 2021-08-05 Shionogi & Co Derivado de dihidropirazolopirazinona que tiene actividad inhibidora de monoacilglicerol aciltransferasa 2 (mgat2).

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5889006A (en) 1995-02-23 1999-03-30 Schering Corporation Muscarinic antagonists
GB9702194D0 (en) 1997-02-04 1997-03-26 Lilly Co Eli Sulphonide derivatives
US6387954B1 (en) 1998-07-31 2002-05-14 Eli Lilly And Company Alkenyl sulphonamide derivatives
US6500865B1 (en) 1998-07-31 2002-12-31 Eli Lilly And Company Sulfonamide derivatives
GB0408777D0 (en) 2004-04-20 2004-05-26 Glaxo Group Ltd Compounds
EP1655283A1 (en) 2004-11-08 2006-05-10 Evotec OAI AG 11beta-HSD1 Inhibitors
EP1659113A1 (en) 2004-11-08 2006-05-24 Evotec AG Inhibitors of 11beta-hydroxy steroid dehydrogenase type 1 (11beta-HSD1)
WO2008038768A1 (fr) 2006-09-28 2008-04-03 Dainippon Sumitomo Pharma Co., Ltd. Composé ayant une structure de pyrimidine bicyclique et composition pharmaceutique comprenant le composé
TW200831092A (en) * 2006-12-21 2008-08-01 Astrazeneca Ab Therapeutic agents
EP2240447A2 (en) * 2007-12-05 2010-10-20 AstraZeneca AB (Publ) Morpholine derivates as antiobesity agents
WO2009086303A2 (en) 2007-12-21 2009-07-09 University Of Rochester Method for altering the lifespan of eukaryotic organisms
US20110015198A1 (en) 2008-03-28 2011-01-20 Banyu Pharmaceutical Co., Inc. Diarylmethylamide derivative having melanin-concentrating hormone receptor antagonism
MX2010013355A (es) * 2008-06-04 2010-12-21 Astrazeneca Ab Nuevos compuestos v.
WO2010095767A1 (en) 2009-02-23 2010-08-26 Banyu Pharmaceutical Co.,Ltd. Pyrimidin-4(3h)-one derivatives
JP2014051434A (ja) 2010-12-28 2014-03-20 Dainippon Sumitomo Pharma Co Ltd 二環性ピリミジン誘導体
WO2013112323A1 (en) 2012-01-23 2013-08-01 Eli Lilly And Company Phenyl methanesulfonamide derivatives useful as mgat - 2 inhibitors
CN104080777B (zh) 2012-01-31 2015-12-09 伊莱利利公司 用作mogat-2抑制剂的吗啉基衍生物
AR089771A1 (es) 2012-01-31 2014-09-17 Lilly Co Eli Derivados de bencil sulfonamida utiles como inhibidores de mogat-2
EA201590696A1 (ru) 2012-11-06 2015-08-31 Эли Лилли Энд Компани Новые бензилсульфонамидные соединения, подходящие в качестве ингибиторов mogat-2

Also Published As

Publication number Publication date
EP2809661A1 (en) 2014-12-10
CO7020914A2 (es) 2014-08-11
WO2013116065A1 (en) 2013-08-08
DOP2014000177A (es) 2014-08-31
IL233542A0 (en) 2014-08-31
HK1199024A1 (zh) 2015-06-19
US20150005305A1 (en) 2015-01-01
AU2013215549A1 (en) 2014-07-17
JP2015504917A (ja) 2015-02-16
GT201400169A (es) 2015-08-27
EA024182B1 (ru) 2016-08-31
BR112014018712A2 (ru) 2017-06-20
EP2809661B1 (en) 2016-04-06
MX2014008604A (es) 2014-08-22
PH12014501712A1 (en) 2014-10-13
BR112014018712A8 (pt) 2017-07-11
ES2571577T3 (es) 2016-05-26
JP5852269B2 (ja) 2016-02-03
SG11201404508XA (en) 2014-10-30
ZA201405227B (en) 2016-05-25
KR20140107641A (ko) 2014-09-04
PH12014501712B1 (en) 2014-10-13
CA2859992A1 (en) 2013-08-08
CL2014001862A1 (es) 2014-11-14
AP2014007793A0 (en) 2014-07-31
US8993568B2 (en) 2015-03-31
CR20140325A (es) 2014-08-25
PE20141789A1 (es) 2014-11-19
AU2013215549B2 (en) 2015-09-03
CN104080777B (zh) 2015-12-09
CN104080777A (zh) 2014-10-01

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG TJ TM RU