EA201491819A1 - Фармацевтические композиции для комбинированного лечения - Google Patents
Фармацевтические композиции для комбинированного леченияInfo
- Publication number
- EA201491819A1 EA201491819A1 EA201491819A EA201491819A EA201491819A1 EA 201491819 A1 EA201491819 A1 EA 201491819A1 EA 201491819 A EA201491819 A EA 201491819A EA 201491819 A EA201491819 A EA 201491819A EA 201491819 A1 EA201491819 A1 EA 201491819A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- pharmaceutical compositions
- tetrabenazine
- combined treatment
- motor disorders
- treatment
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/01—Hydrolysed proteins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Изобретение относится к новым фармацевтическим композициям, которые содержат терапевтически эффективную комбинацию дофаминергического стабилизатора, известного как придопидин, и ингибитора везикулярного транспортера моноаминов 2-го типа (VMAT), известного как тетрабеназин. Предусмотрены фармацевтические композиции для использования в соответствии с изобретением, которые, в частности, можно использовать для улучшения симптоматических терапевтических эффектов и для снижения нежелательных эффектов тетрабеназина при лечении двигательных нарушений и, в частности, двигательных нарушений, связанных с хореей Гентингтона, синдромом Жилля де ла Туретта или поздней дискинезией.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261620203P | 2012-04-04 | 2012-04-04 | |
US201261625192P | 2012-04-17 | 2012-04-17 | |
US201361783730P | 2013-03-14 | 2013-03-14 | |
PCT/US2013/035124 WO2013152105A1 (en) | 2012-04-04 | 2013-04-03 | Pharmaceutical compositions for combination therapy |
Publications (2)
Publication Number | Publication Date |
---|---|
EA201491819A1 true EA201491819A1 (ru) | 2015-04-30 |
EA027748B1 EA027748B1 (ru) | 2017-08-31 |
Family
ID=49292803
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201491819A EA027748B1 (ru) | 2012-04-04 | 2013-04-03 | Применение придопидина в комбинации с тетрабеназином для лечения двигательных нарушений и ожирения |
Country Status (16)
Country | Link |
---|---|
US (3) | US20130267552A1 (ru) |
EP (1) | EP2844346B1 (ru) |
JP (1) | JP6177875B2 (ru) |
KR (1) | KR20150013476A (ru) |
CN (1) | CN104470585A (ru) |
AU (1) | AU2013243461A1 (ru) |
BR (1) | BR112014024672A8 (ru) |
CA (1) | CA2869145A1 (ru) |
EA (1) | EA027748B1 (ru) |
ES (1) | ES2776678T3 (ru) |
HK (1) | HK1206297A1 (ru) |
IL (1) | IL234831B (ru) |
MX (1) | MX2014011971A (ru) |
NZ (1) | NZ630560A (ru) |
WO (1) | WO2013152105A1 (ru) |
ZA (1) | ZA201407726B (ru) |
Families Citing this family (27)
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USRE46117E1 (en) | 1999-12-22 | 2016-08-23 | Teva Pharmaceuticals International Gmbh | Modulators of dopamine neurotransmission |
ES2458592T3 (es) * | 2007-04-12 | 2014-05-06 | IVAX International GmbH | Derivados de N-óxido y/o di-N-óxido de estabilizadores/moduladores de receptores de dopamina que muestran perfiles de efectos secundarios cardiovasculares mejorados |
JP2013536825A (ja) | 2010-09-03 | 2013-09-26 | イバックス・インターナショナル・ゲーエムベーハー | ドパミン作動性安定化剤として有用なプリドピジンの重水素化類似体 |
WO2013034622A1 (en) | 2011-09-07 | 2013-03-14 | Neurosearch A/S | Polymorphic form of pridopidine hydrochloride |
MX347209B (es) | 2011-12-08 | 2017-04-19 | Teva Pharmaceuticals Int Gmbh | La sal de bromhidrato de pridopidina. |
CA2913781C (en) | 2013-06-21 | 2022-05-10 | Teva Pharmaceutical Industries Ltd. | Use of pridopidine for treating huntington's disease |
US11090297B2 (en) | 2013-06-21 | 2021-08-17 | Prilenia Neurotherapeutics Ltd. | Pridopidine for treating huntington's disease |
AU2015209411A1 (en) * | 2014-01-22 | 2016-09-01 | Teva Pharmaceuticals International Gmbh | Modified release formulations of pridopidine |
CA2946518C (en) * | 2014-04-25 | 2022-07-26 | Chugai Seiyaku Kabushiki Kaisha | Preparation containing tetracyclic compound at high dose |
TW201613859A (en) | 2014-06-30 | 2016-04-16 | Teva Pharma | Analogs of PRIDOPIDINE, their preparation and use |
CA2970799A1 (en) | 2014-12-22 | 2016-06-30 | Teva Pharmaceuticals International Gmbh | L-tartrate salt of pridopidine |
US11471449B2 (en) | 2015-02-25 | 2022-10-18 | Prilenia Neurotherapeutics Ltd. | Use of pridopidine to improve cognitive function and for treating Alzheimer's disease |
EP3854785A1 (en) | 2015-02-25 | 2021-07-28 | Prilenia Neurotherapeutics Ltd. | Use of pridopidine to treat depression or anxiety |
AR105434A1 (es) | 2015-07-22 | 2017-10-04 | Teva Pharmaceuticals Int Gmbh | Proceso para preparar pridopidina |
WO2017147366A1 (en) | 2016-02-24 | 2017-08-31 | Teva Pharmaceuticals International Gmbh | Treatment of neurodegenerative eye disease using pridopidine |
AU2017315783C1 (en) | 2016-08-24 | 2020-12-24 | Prilenia Neurotherapeutics Ltd | Use of pridopidine for treating a subject with early stage huntington disease |
CA3035099C (en) | 2016-08-24 | 2023-01-17 | Prilenia Therapeutics Development Ltd. | Use of pridopidine for treating dystonias |
JP6977029B2 (ja) | 2016-09-16 | 2021-12-08 | プリレニア ニューロセラピューティクス リミテッド | レット症候群を治療するためのプリドピジンの使用 |
DK3570940T3 (da) | 2017-01-20 | 2024-02-19 | Prilenia Neurotherapeutics Ltd | Pridopidin til anvendelse i behandling af fragilt x-syndrom |
WO2019010491A1 (en) * | 2017-07-07 | 2019-01-10 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | COMBINATIONS OF MEDICINES FOR THE PROTECTION AGAINST THE DEATH OF NEURONAL CELLS |
US11191758B2 (en) | 2017-07-20 | 2021-12-07 | Neurolixis | Use of selective serotonin 5-HT1A receptor agonists for treating side-effects of VMAT inhibitors |
WO2019036358A1 (en) | 2017-08-14 | 2019-02-21 | Teva Pharmaceuticals International Gmbh | METHODS OF TREATING AMYOTROPHIC LATERAL SCLEROSIS WITH PRIDOPIDINE |
BR112020004045A2 (pt) | 2017-08-30 | 2020-09-01 | Prilenia Neurotherapeutics Ltd. | formas de dosagem de elevada concentração de pridopidina |
WO2020110128A1 (en) * | 2018-11-29 | 2020-06-04 | Prilenia Neurotherapeutics Ltd. | Combination of pridopidine and an additional therapeutic agent for treating drug induced dyskinesia |
CA3075020C (en) * | 2017-09-08 | 2021-12-07 | Prilenia Neurotherapeutics Ltd. | Pridopidine for treating drug induced dyskinesias |
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2013
- 2013-04-03 KR KR1020147030277A patent/KR20150013476A/ko not_active Application Discontinuation
- 2013-04-03 US US13/856,254 patent/US20130267552A1/en not_active Abandoned
- 2013-04-03 BR BR112014024672A patent/BR112014024672A8/pt active Search and Examination
- 2013-04-03 ES ES13772325T patent/ES2776678T3/es active Active
- 2013-04-03 CN CN201380018981.6A patent/CN104470585A/zh active Pending
- 2013-04-03 WO PCT/US2013/035124 patent/WO2013152105A1/en active Application Filing
- 2013-04-03 JP JP2015504706A patent/JP6177875B2/ja active Active
- 2013-04-03 NZ NZ630560A patent/NZ630560A/en not_active IP Right Cessation
- 2013-04-03 AU AU2013243461A patent/AU2013243461A1/en not_active Abandoned
- 2013-04-03 CA CA 2869145 patent/CA2869145A1/en not_active Abandoned
- 2013-04-03 MX MX2014011971A patent/MX2014011971A/es unknown
- 2013-04-03 EP EP13772325.0A patent/EP2844346B1/en active Active
- 2013-04-03 EA EA201491819A patent/EA027748B1/ru active IP Right Revival
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2015
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Also Published As
Publication number | Publication date |
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BR112014024672A8 (pt) | 2018-04-03 |
KR20150013476A (ko) | 2015-02-05 |
HK1206297A1 (en) | 2016-01-08 |
JP2015515475A (ja) | 2015-05-28 |
EA027748B1 (ru) | 2017-08-31 |
NZ630560A (en) | 2016-11-25 |
US20130267552A1 (en) | 2013-10-10 |
CA2869145A1 (en) | 2013-10-10 |
ZA201407726B (en) | 2016-05-25 |
AU2013243461A1 (en) | 2014-11-06 |
ES2776678T3 (es) | 2020-07-31 |
IL234831A0 (en) | 2014-12-31 |
IL234831B (en) | 2020-10-29 |
US20200000785A1 (en) | 2020-01-02 |
US20170266170A1 (en) | 2017-09-21 |
EP2844346A4 (en) | 2015-11-18 |
WO2013152105A1 (en) | 2013-10-10 |
MX2014011971A (es) | 2015-01-16 |
EP2844346B1 (en) | 2020-01-01 |
EP2844346A1 (en) | 2015-03-11 |
BR112014024672A2 (ru) | 2017-06-20 |
JP6177875B2 (ja) | 2017-08-09 |
CN104470585A (zh) | 2015-03-25 |
US11207308B2 (en) | 2021-12-28 |
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