EA201390520A1 - Замещенные соединения пиридазинкарбоксамида - Google Patents

Замещенные соединения пиридазинкарбоксамида

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Publication number
EA201390520A1
EA201390520A1 EA201390520A EA201390520A EA201390520A1 EA 201390520 A1 EA201390520 A1 EA 201390520A1 EA 201390520 A EA201390520 A EA 201390520A EA 201390520 A EA201390520 A EA 201390520A EA 201390520 A1 EA201390520 A1 EA 201390520A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pyridazincarboxamida
substituted compounds
protein kinases
neurological
unexpected
Prior art date
Application number
EA201390520A
Other languages
English (en)
Other versions
EA024809B1 (ru
Inventor
Конгксин ЛИАНГ
Original Assignee
Икскавери Холдинг Кампани, Ллс
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Икскавери Холдинг Кампани, Ллс filed Critical Икскавери Холдинг Кампани, Ллс
Publication of EA201390520A1 publication Critical patent/EA201390520A1/ru
Publication of EA024809B1 publication Critical patent/EA024809B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

Новые производные пиридазина имеют неожиданные лекарственные свойства в качестве ингибиторов протеинкиназ, особенно против ALK, и полезны для лечения нарушений, связанных с аномальной активностью протеинкиназ, как, например, рак, неврологические и психологические заболевания.
EA201390520A 2010-10-08 2011-10-07 Замещенные соединения пиридазинкарбоксамида EA024809B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39142310P 2010-10-08 2010-10-08
PCT/US2011/055428 WO2012048259A2 (en) 2010-10-08 2011-10-07 Substituted pyridazine carboxamide compounds

Publications (2)

Publication Number Publication Date
EA201390520A1 true EA201390520A1 (ru) 2013-09-30
EA024809B1 EA024809B1 (ru) 2016-10-31

Family

ID=45928473

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201390520A EA024809B1 (ru) 2010-10-08 2011-10-07 Замещенные соединения пиридазинкарбоксамида

Country Status (12)

Country Link
US (3) US9126947B2 (ru)
EP (1) EP2625176B1 (ru)
JP (2) JP6023062B2 (ru)
KR (1) KR101886812B1 (ru)
CN (1) CN103298806B (ru)
AU (1) AU2011311814B2 (ru)
BR (1) BR112013008523B1 (ru)
CA (1) CA2813607C (ru)
EA (1) EA024809B1 (ru)
ES (1) ES2610226T3 (ru)
PL (1) PL2625176T3 (ru)
WO (1) WO2012048259A2 (ru)

Families Citing this family (12)

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CN102812018A (zh) * 2010-03-23 2012-12-05 巴斯夫欧洲公司 用于防治无脊椎动物害虫的哒嗪化合物
AU2011311814B2 (en) * 2010-10-08 2016-12-22 Xcovery Holdings, Inc. Substituted pyridazine carboxamide compounds
JP6013029B2 (ja) * 2012-05-25 2016-10-25 千葉県 抗癌剤
RU2550346C2 (ru) 2013-09-26 2015-05-10 Общество с ограниченной ответственностью "Отечественные Фармацевтические Технологии" ООО"ФармТех" Новые химические соединения (варианты) и их применение для лечения онкологических заболеваний
CN105085550B (zh) * 2014-05-21 2017-05-24 海门慧聚药业有限公司 一类alk激酶抑制剂及其制备方法
RU2015110071A (ru) * 2015-03-23 2016-10-10 Общество с ограниченной ответственностью "Отечественные Фармацевтические Технологии" ООО "ФармТех" Применение новых химических соединений (варианты) в качестве ингибиторов nuak1 киназы для лечения онкологических заболеваний
TWI646094B (zh) * 2016-06-01 2019-01-01 大陸商貝達藥業股份有限公司 Crystal form of inhibitory protein kinase active compound and application thereof
RU2631430C1 (ru) * 2016-10-26 2017-09-22 Общество С Ограниченной Ответственностью "Отечественные Фармацевтические Технологии" НОВЫЙ СПОСОБ СИНТЕЗА ПРОИЗВОДНЫХ ТЕТРАГИДРОПИРАЗИНО[2,3-c]ПИРИДАЗИНА
WO2019196812A1 (zh) * 2018-04-09 2019-10-17 上海科技大学 蛋白降解靶向化合物、其抗肿瘤应用、其中间体及中间体应用
WO2022031636A1 (en) 2020-08-03 2022-02-10 Teva Pharmaceuticals International Gmbh Solid state forms of ensartinib and ensartinib salts
WO2023016321A1 (zh) * 2021-08-10 2023-02-16 贝达药业股份有限公司 恩沙替尼或其盐在治疗携带met 14外显子跳跃突变的疾病中的用途
CN116082110B (zh) * 2023-01-09 2024-04-12 北京肿瘤医院(北京大学肿瘤医院) 一种11c标记靶向间变性淋巴瘤激酶alk突变分子探针及应用

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Also Published As

Publication number Publication date
KR20130141514A (ko) 2013-12-26
WO2012048259A2 (en) 2012-04-12
JP6235078B2 (ja) 2017-11-22
EA024809B1 (ru) 2016-10-31
CN103298806A (zh) 2013-09-11
KR101886812B1 (ko) 2018-08-08
EP2625176B1 (en) 2016-08-17
WO2012048259A3 (en) 2012-06-28
CA2813607C (en) 2021-08-31
CN103298806B (zh) 2015-03-18
ES2610226T3 (es) 2017-04-26
AU2011311814A1 (en) 2013-05-02
BR112013008523A2 (pt) 2016-07-12
PL2625176T3 (pl) 2017-08-31
US9126947B2 (en) 2015-09-08
CA2813607A1 (en) 2012-04-12
BR112013008523B1 (pt) 2021-12-07
JP2013539765A (ja) 2013-10-28
EP2625176A4 (en) 2014-04-09
US20180016240A1 (en) 2018-01-18
US20130190298A1 (en) 2013-07-25
JP2016216475A (ja) 2016-12-22
EP2625176A2 (en) 2013-08-14
US20160068493A1 (en) 2016-03-10
JP6023062B2 (ja) 2016-11-09
AU2011311814B2 (en) 2016-12-22

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