BR112013009260A2 - compostos de carboxamida de piridazina substituídos como compostos inibidores de quinase - Google Patents

compostos de carboxamida de piridazina substituídos como compostos inibidores de quinase

Info

Publication number
BR112013009260A2
BR112013009260A2 BR112013009260A BR112013009260A BR112013009260A2 BR 112013009260 A2 BR112013009260 A2 BR 112013009260A2 BR 112013009260 A BR112013009260 A BR 112013009260A BR 112013009260 A BR112013009260 A BR 112013009260A BR 112013009260 A2 BR112013009260 A2 BR 112013009260A2
Authority
BR
Brazil
Prior art keywords
compounds
kinase inhibitor
substituted pyridazine
pyridazine carboxamide
inhibitor compounds
Prior art date
Application number
BR112013009260A
Other languages
English (en)
Inventor
Congxin Liang
Original Assignee
Xcovery Holding Co Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xcovery Holding Co Llc filed Critical Xcovery Holding Co Llc
Publication of BR112013009260A2 publication Critical patent/BR112013009260A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Abstract

compostos de carboxamida de piridazina substituídos como compostos inibidores de quinase. os novos derivados de piridazina têm propriedades de drogas inesperadas como inibidores de proteínas quinase, especialmente contra c-met e são úteis no tratamento de distúrbios relacionados com as atividades da proteína quinase anormais, como o câncer.
BR112013009260A 2010-10-08 2011-10-07 compostos de carboxamida de piridazina substituídos como compostos inibidores de quinase BR112013009260A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39146410P 2010-10-08 2010-10-08
PCT/US2011/055427 WO2012048258A2 (en) 2010-10-08 2011-10-07 Substituted pyridazine carboxamide compounds as kinase inhibitor compounds

Publications (1)

Publication Number Publication Date
BR112013009260A2 true BR112013009260A2 (pt) 2016-07-26

Family

ID=45928472

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013009260A BR112013009260A2 (pt) 2010-10-08 2011-10-07 compostos de carboxamida de piridazina substituídos como compostos inibidores de quinase

Country Status (10)

Country Link
US (1) US9242958B2 (pt)
EP (1) EP2625173A4 (pt)
JP (2) JP5909236B2 (pt)
KR (1) KR20130139987A (pt)
CN (1) CN103298803A (pt)
AU (2) AU2011311813A1 (pt)
BR (1) BR112013009260A2 (pt)
CA (1) CA2813580C (pt)
EA (1) EA025030B1 (pt)
WO (1) WO2012048258A2 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6023062B2 (ja) * 2010-10-08 2016-11-09 エックスカバリー ホールディング カンパニー エルエルシー 置換ピリダジンカルボキサミド化合物
WO2015123453A1 (en) * 2014-02-14 2015-08-20 Portola Pharmaceuticals, Inc. Pyridazine compounds as jak inhibitors
TWI646094B (zh) * 2016-06-01 2019-01-01 大陸商貝達藥業股份有限公司 Crystal form of inhibitory protein kinase active compound and application thereof
CN114364798A (zh) 2019-03-21 2022-04-15 欧恩科斯欧公司 用于治疗癌症的Dbait分子与激酶抑制剂的组合
AU2020378630A1 (en) 2019-11-08 2022-05-26 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008510792A (ja) * 2004-08-26 2008-04-10 ファイザー・インク タンパク質チロシンキナーゼ阻害剤としてのアミノヘテロアリール化合物
KR20080059625A (ko) * 2005-10-04 2008-06-30 칼 짜이스 에스엠테 아게 리소그래피 장치 및 제어 방법
US8551995B2 (en) * 2007-01-19 2013-10-08 Xcovery Holding Company, Llc Kinase inhibitor compounds
BRPI0914305B8 (pt) * 2008-06-19 2021-05-25 Xcovery Holding Co Llc compostos de piridazina carboxamida substituída como compostos inibidores da quinase, uso dos compostos e uso de uma composição compreendendo os compostos

Also Published As

Publication number Publication date
CA2813580C (en) 2017-12-05
EA025030B1 (ru) 2016-11-30
EP2625173A4 (en) 2014-03-26
US9242958B2 (en) 2016-01-26
KR20130139987A (ko) 2013-12-23
WO2012048258A2 (en) 2012-04-12
JP2013539764A (ja) 2013-10-28
JP2016155841A (ja) 2016-09-01
EA201390519A1 (ru) 2013-09-30
CN103298803A (zh) 2013-09-11
WO2012048258A3 (en) 2012-06-28
AU2016262642A1 (en) 2016-12-08
AU2011311813A1 (en) 2013-05-02
CA2813580A1 (en) 2012-04-12
JP5909236B2 (ja) 2016-04-26
EP2625173A2 (en) 2013-08-14
US20130203763A1 (en) 2013-08-08

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notice of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06T Formal requirements before examination [chapter 6.20 patent gazette]
B08F Application fees: application dismissed [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2534 DE 30-07-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

B350 Update of information on the portal [chapter 15.35 patent gazette]