EA201390323A1 - Производные 4-(метиламинофенокси)пиридин-3-илбензамида для лечения рака - Google Patents

Производные 4-(метиламинофенокси)пиридин-3-илбензамида для лечения рака

Info

Publication number
EA201390323A1
EA201390323A1 EA201390323A EA201390323A EA201390323A1 EA 201390323 A1 EA201390323 A1 EA 201390323A1 EA 201390323 A EA201390323 A EA 201390323A EA 201390323 A EA201390323 A EA 201390323A EA 201390323 A1 EA201390323 A1 EA 201390323A1
Authority
EA
Eurasian Patent Office
Prior art keywords
ilbenzamide
methylaminophenoxy
pyridine
cancer
derivatives
Prior art date
Application number
EA201390323A
Other languages
English (en)
Other versions
EA021627B1 (ru
Inventor
Такаси Накагава
Макото Сакамото
Казуя Ямагути
Юки Тераути
Масамити Сиракура
Ясуо Харада
Ютака Кодзима
Такуми Сумида
Original Assignee
Оцука Фармасьютикал Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Оцука Фармасьютикал Ко., Лтд. filed Critical Оцука Фармасьютикал Ко., Лтд.
Publication of EA201390323A1 publication Critical patent/EA201390323A1/ru
Publication of EA021627B1 publication Critical patent/EA021627B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/76—Nitrogen atoms to which a second hetero atom is attached

Abstract

Настоящее изобретение относится к новому соединению, обладающему противоопухолевым действием, стабильностью и метаболической стабильностью. Соединение по настоящему изобретению представлено следующей общей формулой (1):где Rпредставляет собой атом галогена, арильную группу, арилоксигруппу или низшую алкильную группу, необязательно замещенную одним или более атомами галогена; Rпредставляет собой атом водорода, атом галогена, низшую алкильную группу или низшую алкоксигруппу и m равно целому числу от 1 до 3; при условии, что если m равно 2 или 3, Rявляются одинаковыми или различными.
EA201390323A 2010-10-04 2011-10-03 Производные 4-(метиламинофенокси)пиридин-3-илбензамида для лечения рака EA021627B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US38939310P 2010-10-04 2010-10-04
PCT/JP2011/073165 WO2012046825A1 (en) 2010-10-04 2011-10-03 4- (methylaminophenoxy) pyrdin- 3 - yl - benzamide derivatives for treating cancer

Publications (2)

Publication Number Publication Date
EA201390323A1 true EA201390323A1 (ru) 2013-09-30
EA021627B1 EA021627B1 (ru) 2015-07-30

Family

ID=44872549

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201390323A EA021627B1 (ru) 2010-10-04 2011-10-03 Производные 4-(метиламинофенокси)пиридин-3-илбензамида для лечения рака

Country Status (29)

Country Link
US (7) US8946437B2 (ru)
EP (1) EP2624833B1 (ru)
JP (1) JP5715690B2 (ru)
KR (1) KR101797797B1 (ru)
CN (1) CN103189061B (ru)
AR (1) AR083287A1 (ru)
AU (1) AU2011313236B2 (ru)
BR (1) BR112013007841B1 (ru)
CA (1) CA2813153C (ru)
CO (1) CO6660459A2 (ru)
DK (1) DK2624833T3 (ru)
EA (1) EA021627B1 (ru)
ES (1) ES2526574T3 (ru)
HK (1) HK1187540A1 (ru)
HR (1) HRP20141237T1 (ru)
IL (1) IL225520A (ru)
MX (1) MX2013003589A (ru)
MY (1) MY157563A (ru)
NZ (1) NZ609151A (ru)
PL (1) PL2624833T3 (ru)
PT (1) PT2624833E (ru)
RS (1) RS53749B1 (ru)
SG (1) SG189146A1 (ru)
SI (1) SI2624833T1 (ru)
SM (1) SMT201500056B (ru)
TW (1) TWI526431B (ru)
UA (1) UA110037C2 (ru)
WO (1) WO2012046825A1 (ru)
ZA (1) ZA201302332B (ru)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA110037C2 (ru) * 2010-10-04 2015-11-10 Оцука Фармас'Ютікел Ко., Лтд. Производные 4-(метиламинофенокси)пиридин-3-иллбензамида для лечения рака
JP6066806B2 (ja) * 2012-04-03 2017-01-25 大塚製薬株式会社 医薬
EP3946328A1 (en) 2019-03-25 2022-02-09 Otsuka Pharmaceutical Co., Ltd. Antitumor composition

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6022884A (en) * 1997-11-07 2000-02-08 Amgen Inc. Substituted pyridine compounds and methods of use
JP2001089412A (ja) 1999-09-22 2001-04-03 Otsuka Pharmaceut Co Ltd ベンゼン誘導体またはその医薬的に許容される塩
MX2007001215A (es) 2004-08-06 2007-04-17 Otsuka Pharma Co Ltd Compuestos aromaticos.
US8236826B2 (en) * 2005-12-05 2012-08-07 Otsuka Pharmaceutical Co., Ltd. Diarylether derivatives as antitumor agents
UA95978C2 (ru) * 2006-10-02 2011-09-26 Оцука Фармас'Ютікел Ко., Лтд. Ингибитор активации stat3/5
UA110037C2 (ru) * 2010-10-04 2015-11-10 Оцука Фармас'Ютікел Ко., Лтд. Производные 4-(метиламинофенокси)пиридин-3-иллбензамида для лечения рака
EP3946328A1 (en) * 2019-03-25 2022-02-09 Otsuka Pharmaceutical Co., Ltd. Antitumor composition

Also Published As

Publication number Publication date
IL225520A (en) 2016-05-31
CO6660459A2 (es) 2013-04-30
CN103189061B (zh) 2015-09-02
SMT201500056B (it) 2015-05-05
US20230139808A1 (en) 2023-05-04
MX2013003589A (es) 2013-06-24
JP5715690B2 (ja) 2015-05-13
MY157563A (en) 2016-06-30
DK2624833T3 (en) 2015-01-05
ZA201302332B (en) 2014-07-30
CN103189061A (zh) 2013-07-03
CA2813153C (en) 2019-01-15
SG189146A1 (en) 2013-05-31
TWI526431B (zh) 2016-03-21
JP2013538785A (ja) 2013-10-17
KR101797797B1 (ko) 2017-11-14
CA2813153A1 (en) 2012-04-12
PL2624833T3 (pl) 2015-05-29
NZ609151A (en) 2015-01-30
BR112013007841B1 (pt) 2020-03-03
WO2012046825A1 (en) 2012-04-12
US20180265471A1 (en) 2018-09-20
AU2011313236A1 (en) 2013-04-18
KR20130121826A (ko) 2013-11-06
RS53749B1 (en) 2015-06-30
EA021627B1 (ru) 2015-07-30
AR083287A1 (es) 2013-02-13
IL225520A0 (en) 2013-06-27
US20130267565A1 (en) 2013-10-10
US20170298023A1 (en) 2017-10-19
HRP20141237T1 (hr) 2015-02-13
US20210017134A1 (en) 2021-01-21
BR112013007841A2 (pt) 2016-06-07
HK1187540A1 (en) 2014-04-11
UA110037C2 (ru) 2015-11-10
US20150105432A1 (en) 2015-04-16
EP2624833A1 (en) 2013-08-14
TW201307289A (zh) 2013-02-16
US20200031773A1 (en) 2020-01-30
ES2526574T3 (es) 2015-01-13
SI2624833T1 (sl) 2015-03-31
US8946437B2 (en) 2015-02-03
AU2011313236B2 (en) 2016-05-19
PT2624833E (pt) 2014-12-26
EP2624833B1 (en) 2014-12-10

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