EA201390756A1 - Модулирующие nk-клетки терапии и способы для лечения гематологических злокачественных заболеваний - Google Patents

Модулирующие nk-клетки терапии и способы для лечения гематологических злокачественных заболеваний

Info

Publication number
EA201390756A1
EA201390756A1 EA201390756A EA201390756A EA201390756A1 EA 201390756 A1 EA201390756 A1 EA 201390756A1 EA 201390756 A EA201390756 A EA 201390756A EA 201390756 A EA201390756 A EA 201390756A EA 201390756 A1 EA201390756 A1 EA 201390756A1
Authority
EA
Eurasian Patent Office
Prior art keywords
treatment
methods
modulating
malignant diseases
cell treatments
Prior art date
Application number
EA201390756A
Other languages
English (en)
Other versions
EA035033B1 (ru
Inventor
Паскаль Андре
Рено Бюффе
Марсель Розенсвейг
Жером Тиоллье
Original Assignee
Иннейт Фарма Са
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Иннейт Фарма Са filed Critical Иннейт Фарма Са
Publication of EA201390756A1 publication Critical patent/EA201390756A1/ru
Publication of EA035033B1 publication Critical patent/EA035033B1/ru

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Обеспечены композиции, содержащие соединения, которые нейтрализуют ингибирующие NK-клетки рецепторы, и способы применения таких композиций в лечении гематологических раковых заболеваний.
EA201390756A 2010-11-22 2011-11-22 Способ лечения гематологического предракового или гематологического ракового заболеваний EA035033B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41597310P 2010-11-22 2010-11-22
PCT/US2011/061840 WO2012071411A2 (en) 2010-11-22 2011-11-22 Nk cell modulating treatments and methods for treatment of hematological malignancies

Publications (2)

Publication Number Publication Date
EA201390756A1 true EA201390756A1 (ru) 2014-11-28
EA035033B1 EA035033B1 (ru) 2020-04-20

Family

ID=46146390

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201390756A EA035033B1 (ru) 2010-11-22 2011-11-22 Способ лечения гематологического предракового или гематологического ракового заболеваний

Country Status (11)

Country Link
US (1) US9844593B2 (ru)
EP (1) EP2643350A4 (ru)
JP (2) JP6224457B2 (ru)
CN (2) CN103298831A (ru)
AR (1) AR083957A1 (ru)
BR (1) BR112013012138B1 (ru)
CA (1) CA2818684C (ru)
EA (1) EA035033B1 (ru)
MX (1) MX355483B (ru)
TW (1) TWI664191B (ru)
WO (1) WO2012071411A2 (ru)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090191213A9 (en) * 2003-07-02 2009-07-30 Novo Nordisk A/S Compositions and methods for regulating NK cell activity
EP3072522B1 (en) * 2005-01-06 2019-04-24 Novo Nordisk A/S Anti-kir combination treatments and methods
TWI560200B (en) * 2011-05-25 2016-12-01 Innate Pharma Sa Anti-kir antibodies for the treatment of inflammatory and autoimmune disorders
US11471486B2 (en) 2012-09-04 2022-10-18 Inven2 As Selective and controlled expansion of educated NK cells
NZ631405A (en) 2012-10-02 2017-01-27 Bristol Myers Squibb Co Combination of anti-kir antibodies and anti-pd-1 antibodies to treat cancer
JP6449777B2 (ja) 2012-12-21 2019-01-09 シアトル ジェネティックス, インコーポレイテッド 抗ntb−a抗体ならびに関連する組成物および方法
US9511092B2 (en) 2013-01-28 2016-12-06 St. Jude Children's Research Hospital, Inc. Chimeric receptor with NKG2D specificity for use in cell therapy against cancer and infectious disease
MX370173B (es) * 2013-05-03 2019-12-04 Ohio State Innovation Foundation Células efectoras inmunitarias modificadas genéticamente con el receptor de antígenos quiméricos específico de cs1.
WO2015069785A1 (en) 2013-11-06 2015-05-14 Bristol-Myers Squibb Company Combination of anti-kir and anti-cs1 antibodies to treat multiple myeloma
CA2948462A1 (en) 2014-05-15 2015-11-19 National University Of Singapore Modified natural killer cells and uses thereof
WO2015195555A1 (en) * 2014-06-16 2015-12-23 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Blocking cd38 using anti-cd38 antibody conjugated to protein g to protect nk cells
US10617757B2 (en) 2014-08-08 2020-04-14 The Regents Of The University Of California Methods for treating multiple myeloma
CN107530424A (zh) 2015-02-20 2018-01-02 俄亥俄州国家创新基金会 针对nkg2d和肿瘤相关抗原的二价抗体
RU2571551C1 (ru) * 2015-04-16 2015-12-20 Закрытое акционерное общество "ПЕПТЕК" Специфическая сочетанная терапия злокачественных опухолей цитостатиком и его модификатором
BR112017021688A2 (pt) 2015-04-17 2018-08-14 Bristol-Myers Squibb Company composições compreendendo uma combinação de um anticorpo anti-pd-1 e outro anticorpo
EP3461337A1 (en) 2015-05-06 2019-04-03 Snipr Technologies Limited Altering microbial populations & modifying microbiota
EP3325967B1 (en) 2015-07-24 2019-12-04 Innate Pharma Methods for detecting tissue infiltrating nk cells
CA3004530A1 (en) 2015-11-07 2017-05-11 Multivir Inc. Methods and compositions comprising tumor suppressor gene therapy and immune checkpoint blockade for the treatment of cancer
IL292302B2 (en) 2016-05-20 2023-10-01 Biohaven Pharm Holding Co Ltd Use of glutamate modulating factors in cancer immunotherapy
US11623958B2 (en) 2016-05-20 2023-04-11 Harpoon Therapeutics, Inc. Single chain variable fragment CD3 binding proteins
KR101926166B1 (ko) * 2016-05-24 2018-12-06 재단법인 아산사회복지재단 수용체 시너지 활성을 이용한 nk 세포의 활성도 검사 방법 및 이를 이용한 nk 세포의 활성도가 관련된 질환의 진단 방법
GB201609811D0 (en) 2016-06-05 2016-07-20 Snipr Technologies Ltd Methods, cells, systems, arrays, RNA and kits
US11395838B2 (en) 2016-09-27 2022-07-26 Board Of Regents, The University Of Texas System Methods for enhancing immune checkpoint blockade therapy by modulating the microbiome
BR112019007365A2 (pt) 2016-10-12 2019-07-09 Univ Texas métodos e composições para imunoterapia com tusc2
EP3551226A1 (en) 2016-12-12 2019-10-16 MultiVir Inc. Methods and compositions comprising viral gene therapy and an immune checkpoint inhibitor for treatment and prevention of cancer and infectious diseases
EP3579879A4 (en) 2017-02-09 2020-12-16 Memorial Sloan Kettering Cancer Center ANTI-BODY ANTI-KIR3DL1
CA3056439A1 (en) 2017-03-27 2018-10-04 National University Of Singapore Truncated nkg2d chimeric receptors and uses thereof in natural killer cell immunotherapy
WO2018182511A1 (en) 2017-03-27 2018-10-04 National University Of Singapore Stimulatory cell lines for ex vivo expansion and activation of natural killer cells
JP7458188B2 (ja) 2017-03-31 2024-03-29 ブリストル-マイヤーズ スクイブ カンパニー 腫瘍を処置する方法
AU2018265856B2 (en) 2017-05-12 2023-04-27 Harpoon Therapeutics, Inc. Mesothelin binding proteins
BR112020007249B1 (pt) 2017-10-13 2022-11-22 Harpoon Therapeutics, Inc Roteína de ligação a antígeno de maturação de célula b, proteína de ligação multiespecífica e uso das referidas proteínas
JP2020536894A (ja) 2017-10-15 2020-12-17 ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company 腫瘍処置法
KR20200135986A (ko) 2018-03-19 2020-12-04 멀티비르 인코포레이티드 종양 억제인자 유전자 치료 및 cd122/cd132 작용제를 포함하는 암 치료를 위한 방법 및 조성물
AU2019236865A1 (en) 2018-03-23 2020-10-01 Bristol-Myers Squibb Company Antibodies against MICA and/or MICB and uses thereof
CN112292145A (zh) 2018-03-25 2021-01-29 斯尼普生物群系有限公司 治疗和预防微生物感染
US10760075B2 (en) 2018-04-30 2020-09-01 Snipr Biome Aps Treating and preventing microbial infections
KR20200139724A (ko) 2018-03-30 2020-12-14 브리스톨-마이어스 스큅 컴퍼니 종양을 치료하는 방법
WO2019195769A1 (en) * 2018-04-06 2019-10-10 The Brigham And Women's Hospital, Inc. Methods of diagnosing and treating aggressive cutaneous t-cell lymphomas
CN108728527B (zh) * 2018-06-06 2020-06-09 青岛泱深生物医药有限公司 Hcst基因作为诊治子痫前期的靶标
KR20210035805A (ko) 2018-06-15 2021-04-01 플래그쉽 파이어니어링 이노베이션스 브이, 인크. 세포후 신호전달 인자의 조절을 통한 면역 활성의 증가
CA3114038A1 (en) 2018-09-25 2020-04-02 Harpoon Therapeutics, Inc. Dll3 binding proteins and methods of use
US20220054524A1 (en) 2018-12-21 2022-02-24 Onxeo New conjugated nucleic acid molecules and their uses
KR102210455B1 (ko) * 2019-02-28 2021-02-02 사회복지법인 삼성생명공익재단 자연살해세포 활성 검출용 미세입자 및 이를 이용한 검출 방법
WO2020180882A1 (en) 2019-03-05 2020-09-10 Nkarta, Inc. Cd19-directed chimeric antigen receptors and uses thereof in immunotherapy
MA55805A (fr) 2019-05-03 2022-03-09 Flagship Pioneering Innovations V Inc Métodes de modulation de l'activité immunitaire
CN111973739B (zh) * 2019-05-23 2024-02-13 正大天晴药业集团股份有限公司 抗pd-l1单克隆抗体治疗癌症的用途
CN114127315A (zh) 2019-05-30 2022-03-01 百时美施贵宝公司 鉴定适合于免疫肿瘤学(i-o)疗法的受试者的方法
JP2022534967A (ja) 2019-05-30 2022-08-04 ブリストル-マイヤーズ スクイブ カンパニー 多腫瘍遺伝子シグネチャーおよびその使用
US20220233691A1 (en) 2019-05-30 2022-07-28 Bristol-Myers Squibb Company Cell localization signature and combination therapy
WO2021024020A1 (en) 2019-08-06 2021-02-11 Astellas Pharma Inc. Combination therapy involving antibodies against claudin 18.2 and immune checkpoint inhibitors for treatment of cancer
WO2021113644A1 (en) 2019-12-05 2021-06-10 Multivir Inc. Combinations comprising a cd8+ t cell enhancer, an immune checkpoint inhibitor and radiotherapy for targeted and abscopal effects for the treatment of cancer
JP2023509359A (ja) 2019-12-17 2023-03-08 フラグシップ パイオニアリング イノベーションズ ブイ,インコーポレーテッド 鉄依存性細胞分解の誘導物質との併用抗癌療法
TW202214857A (zh) 2020-06-19 2022-04-16 法商昂席歐公司 新型結合核酸分子及其用途
CN116096906A (zh) 2020-06-29 2023-05-09 旗舰创业创新五公司 工程化以促进萨诺传递的病毒及其在治疗癌症中的用途
MX2023000197A (es) 2020-07-07 2023-02-22 BioNTech SE Arn terapeutico para el cancer positivo para vph.
CN114222761B (zh) * 2020-07-14 2024-02-20 浙江道尔生物科技有限公司 一种抗cld18a2的单域抗体
BR112023003553A2 (pt) 2020-08-31 2023-04-04 Bristol Myers Squibb Co Assinatura de localização celular e imunoterapia
WO2022120179A1 (en) 2020-12-03 2022-06-09 Bristol-Myers Squibb Company Multi-tumor gene signatures and uses thereof
WO2022135666A1 (en) 2020-12-21 2022-06-30 BioNTech SE Treatment schedule for cytokine proteins
TW202245808A (zh) 2020-12-21 2022-12-01 德商拜恩迪克公司 用於治療癌症之治療性rna
WO2022135667A1 (en) 2020-12-21 2022-06-30 BioNTech SE Therapeutic rna for treating cancer
EP4267172A1 (en) 2020-12-28 2023-11-01 Bristol-Myers Squibb Company Subcutaneous administration of pd1/pd-l1 antibodies
AU2021411486A1 (en) 2020-12-28 2023-06-29 Bristol-Myers Squibb Company Antibody compositions and methods of use thereof
CA3209479A1 (en) 2021-02-03 2022-08-11 Mozart Therapeutics, Inc. Binding agents and methods of using the same
EP4314068A1 (en) 2021-04-02 2024-02-07 The Regents Of The University Of California Antibodies against cleaved cdcp1 and uses thereof
CA3225254A1 (en) 2021-07-13 2023-01-19 BioNTech SE Multispecific binding agents against cd40 and cd137 in combination therapy for cancer
KR20240038769A (ko) * 2021-07-28 2024-03-25 머크 샤프 앤드 돔 엘엘씨 항-ilt3 항체를 사용하여 급성 골수성 백혈병을 치료하는 방법
TW202333802A (zh) 2021-10-11 2023-09-01 德商拜恩迪克公司 用於肺癌之治療性rna(二)
WO2023076876A1 (en) 2021-10-26 2023-05-04 Mozart Therapeutics, Inc. Modulation of immune responses to viral vectors
WO2023111203A1 (en) 2021-12-16 2023-06-22 Onxeo New conjugated nucleic acid molecules and their uses
WO2023178329A1 (en) 2022-03-18 2023-09-21 Bristol-Myers Squibb Company Methods of isolating polypeptides
WO2023235847A1 (en) 2022-06-02 2023-12-07 Bristol-Myers Squibb Company Antibody compositions and methods of use thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030105294A1 (en) * 1998-02-25 2003-06-05 Stephen Gillies Enhancing the circulating half life of antibody-based fusion proteins
NZ536908A (en) * 2002-05-17 2008-09-26 Celgene Corp Treating or preventing cancer comprising administering an effective amount of cytokine inhibitory drug plus a second active ingredient
US7968569B2 (en) * 2002-05-17 2011-06-28 Celgene Corporation Methods for treatment of multiple myeloma using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione
KR101325023B1 (ko) 2003-07-02 2013-11-04 노보 노르디스크 에이/에스 Nk 세포 활성을 조절하기 위한 조성물 및 방법
CN1852924A (zh) * 2003-07-02 2006-10-25 依奈特制药公司 Pan-kir2dl nk-受体的抗体及其在诊断及治疗中的应用
HUE033129T2 (en) * 2003-07-24 2017-11-28 Innate Pharma Sa Methods and compositions for increasing the efficacy of therapeutic antibodies using compounds that potentiate NK cells
DK2287195T3 (da) 2004-07-01 2019-08-19 Innate Pharma Pan-kir2dl nk-receptor-antistoffer og anvendelse heraf i diagnostik og terapi
EP3072522B1 (en) * 2005-01-06 2019-04-24 Novo Nordisk A/S Anti-kir combination treatments and methods
US8222376B2 (en) 2005-01-06 2012-07-17 Novo Nordisk A/S KIR-binding agents and methods of use thereof
EP2109460B1 (en) * 2007-01-11 2016-05-18 Novo Nordisk A/S Anti-kir antibodies, formulations, and uses thereof
US20100099084A1 (en) 2008-10-17 2010-04-22 Maher Albitar Detection of npm1 nucleic acid in acellular body fluids

Also Published As

Publication number Publication date
CN103298831A (zh) 2013-09-11
US9844593B2 (en) 2017-12-19
CN106963947A (zh) 2017-07-21
JP2016199549A (ja) 2016-12-01
BR112013012138B1 (pt) 2022-02-22
BR112013012138A2 (pt) 2020-09-01
US20130251711A1 (en) 2013-09-26
TWI664191B (zh) 2019-07-01
TW201305210A (zh) 2013-02-01
JP6224457B2 (ja) 2017-11-01
EP2643350A2 (en) 2013-10-02
CA2818684C (en) 2023-02-21
JP2014501729A (ja) 2014-01-23
WO2012071411A3 (en) 2012-08-16
EA035033B1 (ru) 2020-04-20
MX2013005673A (es) 2013-12-06
EP2643350A4 (en) 2015-01-07
MX355483B (es) 2018-04-19
AR083957A1 (es) 2013-04-10
WO2012071411A2 (en) 2012-05-31
CA2818684A1 (en) 2012-05-31

Similar Documents

Publication Publication Date Title
EA201390756A1 (ru) Модулирующие nk-клетки терапии и способы для лечения гематологических злокачественных заболеваний
EA201890754A1 (ru) Соединения и способы их применения
EA201590997A1 (ru) Соединения и способы их применения
MX342274B (es) Actividades de la piruvato quinasa m2 (pkm2).
MX360404B (es) Compuestos para inhibir la proliferacion celular en canceres transmitidos por egfr.
EA201300171A1 (ru) Способы и композиции для терапии рака печени
EA201591327A1 (ru) Замещенные пирролопиримидиновые соединения, их композиции и способы лечения с использованием таких соединений
CA2900335C (en) Synthetic analogs of epipolythiodioxopiperazines and uses thereof
EA201171367A1 (ru) Винилиндазолильные соединения
MX371108B (es) Pirimidopirimidinonas utiles como iniciadores de wee-1 cinasa.
EA201992251A1 (ru) Противораковые вакцины и способы лечения с их применением
IN2012DN00471A (ru)
UA109464C2 (ru) Спироксиндольные антагонисты mdm2
ECSP15012462A (es) Modulación de la expresión de receptores androgénicos
PH12015502161A1 (en) Therapeutic compounds and compositions
EA201400178A1 (ru) Лечение рака молочной железы
EA201792465A1 (ru) Соединения для лечения спинальной мышечной атрофии
EA201201000A1 (ru) Способы лечения колоректального рака
MX366804B (es) Translocaciones de la r-espondina y sus metodos de uso.
EA201200999A1 (ru) Способы лечения рака молочной железы
MX2012010434A (es) Compuestos y composiciones novedosas para atacar a las celulas madre del cancer.
NZ723971A (en) Methods and compositions for treating ewings sarcoma family of tumors
MX2014012477A (es) Inhibidores pirrolopirazona de tanquirasa.
EA201170288A1 (ru) Оксабициклогептаны и оксабициклогептены, их получение и применение
UA112326C2 (uk) Засоби, що викликають апоптоз, для лікування злоякісних новоутворень і імунних і аутоімунних захворювань

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM