EA201291105A1 - Пероральная вакцина, содержащая антиген и агонист toll-подобного рецептора - Google Patents

Пероральная вакцина, содержащая антиген и агонист toll-подобного рецептора

Info

Publication number
EA201291105A1
EA201291105A1 EA201291105A EA201291105A EA201291105A1 EA 201291105 A1 EA201291105 A1 EA 201291105A1 EA 201291105 A EA201291105 A EA 201291105A EA 201291105 A EA201291105 A EA 201291105A EA 201291105 A1 EA201291105 A1 EA 201291105A1
Authority
EA
Eurasian Patent Office
Prior art keywords
toll
agonist
receptor
vaccine containing
containing antigen
Prior art date
Application number
EA201291105A
Other languages
English (en)
Inventor
Надиа Оуэкед
Мартин Плэйнт
Даниель Ларок
Кори Патрик Маллетт
Original Assignee
Глаксосмитклайн Байолоджикалс С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Глаксосмитклайн Байолоджикалс С.А. filed Critical Глаксосмитклайн Байолоджикалс С.А.
Publication of EA201291105A1 publication Critical patent/EA201291105A1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/542—Mucosal route oral/gastrointestinal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55516—Proteins; Peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55588—Adjuvants of undefined constitution
    • A61K2039/55594—Adjuvants of undefined constitution from bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

В изобретении предлагается иммуногенная композиция, содержащая один или более антигенов и агонист Toll-подобного рецептора (TLR) в перорально (например, сублингвально) вводимой композиции.
EA201291105A 2010-06-03 2011-06-02 Пероральная вакцина, содержащая антиген и агонист toll-подобного рецептора EA201291105A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1009273.2A GB201009273D0 (en) 2010-06-03 2010-06-03 Novel vaccine
PCT/EP2011/059167 WO2011151431A1 (en) 2010-06-03 2011-06-02 Oral vaccine comprising an antigen and a toll-like receptor agonist

Publications (1)

Publication Number Publication Date
EA201291105A1 true EA201291105A1 (ru) 2013-05-30

Family

ID=42471081

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201291105A EA201291105A1 (ru) 2010-06-03 2011-06-02 Пероральная вакцина, содержащая антиген и агонист toll-подобного рецептора

Country Status (15)

Country Link
US (1) US20130089570A1 (ru)
EP (1) EP2575871A1 (ru)
JP (1) JP2013527218A (ru)
KR (1) KR20130082139A (ru)
CN (1) CN102905726A (ru)
AU (1) AU2011260215B2 (ru)
BR (1) BR112012030552A2 (ru)
CA (1) CA2801266A1 (ru)
EA (1) EA201291105A1 (ru)
GB (1) GB201009273D0 (ru)
IL (1) IL223151A0 (ru)
MX (1) MX2012014083A (ru)
SG (1) SG185729A1 (ru)
WO (1) WO2011151431A1 (ru)
ZA (1) ZA201208915B (ru)

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Also Published As

Publication number Publication date
AU2011260215A1 (en) 2013-01-17
IL223151A0 (en) 2013-02-03
CA2801266A1 (en) 2011-12-08
WO2011151431A1 (en) 2011-12-08
CN102905726A (zh) 2013-01-30
GB201009273D0 (en) 2010-07-21
AU2011260215B2 (en) 2014-06-12
SG185729A1 (en) 2012-12-28
KR20130082139A (ko) 2013-07-18
EP2575871A1 (en) 2013-04-10
JP2013527218A (ja) 2013-06-27
ZA201208915B (en) 2014-04-30
MX2012014083A (es) 2013-01-29
BR112012030552A2 (pt) 2016-08-16
US20130089570A1 (en) 2013-04-11

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