EA201270590A1 - Ингибиторы акт - Google Patents

Ингибиторы акт

Info

Publication number
EA201270590A1
EA201270590A1 EA201270590A EA201270590A EA201270590A1 EA 201270590 A1 EA201270590 A1 EA 201270590A1 EA 201270590 A EA201270590 A EA 201270590A EA 201270590 A EA201270590 A EA 201270590A EA 201270590 A1 EA201270590 A1 EA 201270590A1
Authority
EA
Eurasian Patent Office
Prior art keywords
active inhibitors
compounds
formula
present
inhibitors
Prior art date
Application number
EA201270590A
Other languages
English (en)
Other versions
EA020151B1 (ru
Inventor
Дуглас Вэйд Бэйт
Тимоти Пол Беркхолдер
Джошуа Райан Клэйтон
МариДжин Эгген
Кеннет Джеймс Джуниор Генри
Дидре Мичелл Джонс
Сараванан Партасарати
Хуасин Пэй
Марк Эдвард Ремпала
Джейсон Скотт Сойер
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA201270590A1 publication Critical patent/EA201270590A1/ru
Publication of EA020151B1 publication Critical patent/EA020151B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

В настоящем изобретении предложены ингибиторы АКТ формулы IВ настоящем изобретении также предложены фармацевтические композиции, содержащие соединения формулы I, применение соединений этой формулы и способ применения таких соединений.
EA201270590A 2009-10-23 2010-10-20 Ингибиторы akt и фармацевтические составы, их содержащие EA020151B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25430809P 2009-10-23 2009-10-23
PCT/US2010/053295 WO2011050016A1 (en) 2009-10-23 2010-10-20 Akt inhibitors

Publications (2)

Publication Number Publication Date
EA201270590A1 true EA201270590A1 (ru) 2012-09-28
EA020151B1 EA020151B1 (ru) 2014-09-30

Family

ID=43467018

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201270590A EA020151B1 (ru) 2009-10-23 2010-10-20 Ингибиторы akt и фармацевтические составы, их содержащие

Country Status (12)

Country Link
US (1) US8436002B2 (ru)
EP (1) EP2491032B1 (ru)
JP (1) JP5581390B2 (ru)
KR (1) KR101398268B1 (ru)
CN (1) CN102574852B (ru)
AU (1) AU2010310786B2 (ru)
BR (1) BR112012011328A2 (ru)
CA (1) CA2778291C (ru)
EA (1) EA020151B1 (ru)
ES (1) ES2465094T3 (ru)
MX (1) MX2012004780A (ru)
WO (1) WO2011050016A1 (ru)

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BR112014028573B1 (pt) 2012-05-17 2021-11-16 Genentech, Inc Processo de fabricação de compostos de ciclopentapirimidina hidroxilada
KR20220143143A (ko) 2012-05-17 2022-10-24 제넨테크, 인크. 무정형 형태의 akt 저해성 피리미디닐 - 사이클로펜탄 화합물, 조성물 및 이들의 방법
EP2861582B1 (en) 2012-05-17 2016-05-25 Array Biopharma, Inc. Process for making hydroxylated cyclopentylpyrimidine compounds
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AU2014228385B2 (en) * 2013-03-11 2018-08-09 Merck Patent Gmbh 6-[4-(1-H-imidazol-2-yl]piperidin-1 -yl]pyrimidin-4-amine derivatives as modulators of kinase activity
US9993460B2 (en) 2013-07-26 2018-06-12 Race Oncology Ltd. Compositions to improve the therapeutic benefit of bisantrene and analogs and derivatives thereof
CA2922398C (en) 2013-09-12 2023-08-29 Dana-Farber Cancer Institute, Inc. Methods for evaluating and treating waldenstrom's macroglobulinemia
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US9925192B2 (en) 2014-02-28 2018-03-27 Merck Sharp & Dohme Corp. Method for treating cancer
MA45048A (fr) * 2016-05-20 2019-03-27 Taiho Pharmaceutical Co Ltd Nouveau dérivé de 5h-pyrrolo[2,3-d]pyrimidin-6(7h)-one
AU2020214258A1 (en) * 2019-01-29 2021-09-16 Nanjing Chia Tai Tianqing Pharmaceutical Co., Ltd. AKT inhibitor
WO2021228223A1 (zh) * 2020-05-15 2021-11-18 南京正大天晴制药有限公司 氘代akt激酶抑制剂
US20230321108A1 (en) * 2020-07-22 2023-10-12 Nanjing Chia Tai Tianqing Pharmaceutical Co., Ltd. Unit dosage composition of akt inhibitor
EP4186902A1 (en) * 2020-07-22 2023-05-31 Nanjing Chia Tai Tianqing Pharmaceutical Co., Ltd. Salt of dihydropyrido[2,3-d]pyrimidinone derivative, preparation method therefor, and use thereof
US20230271958A1 (en) * 2020-07-22 2023-08-31 Nanjing Chia Tai Tianqing Pharmaceutical Co., Ltd. SALT AND CRYSTAL FORM OF DIHYDROPYRIDO[2,3-d]PYRIMIDINE DERIVATE

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Also Published As

Publication number Publication date
US20120149684A1 (en) 2012-06-14
AU2010310786A1 (en) 2012-04-19
AU2010310786B2 (en) 2014-03-27
WO2011050016A1 (en) 2011-04-28
JP2013508382A (ja) 2013-03-07
CA2778291C (en) 2014-02-11
CN102574852A (zh) 2012-07-11
ES2465094T3 (es) 2014-06-05
KR101398268B1 (ko) 2014-05-23
CA2778291A1 (en) 2011-04-28
EP2491032A1 (en) 2012-08-29
BR112012011328A2 (pt) 2016-11-22
US8436002B2 (en) 2013-05-07
JP5581390B2 (ja) 2014-08-27
CN102574852B (zh) 2014-06-25
EA020151B1 (ru) 2014-09-30
MX2012004780A (es) 2012-08-23
KR20120068941A (ko) 2012-06-27
EP2491032B1 (en) 2014-04-16

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU