BR112012011328A2 - inibidores de akt - Google Patents

inibidores de akt

Info

Publication number
BR112012011328A2
BR112012011328A2 BR112012011328A BR112012011328A BR112012011328A2 BR 112012011328 A2 BR112012011328 A2 BR 112012011328A2 BR 112012011328 A BR112012011328 A BR 112012011328A BR 112012011328 A BR112012011328 A BR 112012011328A BR 112012011328 A2 BR112012011328 A2 BR 112012011328A2
Authority
BR
Brazil
Prior art keywords
akt inhibitors
formula
compounds
relates
present
Prior art date
Application number
BR112012011328A
Other languages
English (en)
Inventor
Deidre Michelle Johns
Douglas Wade Beight
Huaxing Pei
Jason Scott Sawyer
Joshua Ryan Clayton
Kenneth James Junior Henry
Marijean Eggen
Mark Edward Rempala
Saravanan Parthasarathy
Timothy Paul Burkholder
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of BR112012011328A2 publication Critical patent/BR112012011328A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

inibidores de akt a presente invenção refere-se a inibidores de akt da fórmula: a presente invenção também se refere a composições faramcêuticas compreendendo compostos de fórmula l, usos de compostos de fórmula l e método de uso de compostos de fórmula l.
BR112012011328A 2009-10-23 2010-10-20 inibidores de akt BR112012011328A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25430809P 2009-10-23 2009-10-23
PCT/US2010/053295 WO2011050016A1 (en) 2009-10-23 2010-10-20 Akt inhibitors

Publications (1)

Publication Number Publication Date
BR112012011328A2 true BR112012011328A2 (pt) 2016-11-22

Family

ID=43467018

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012011328A BR112012011328A2 (pt) 2009-10-23 2010-10-20 inibidores de akt

Country Status (12)

Country Link
US (1) US8436002B2 (pt)
EP (1) EP2491032B1 (pt)
JP (1) JP5581390B2 (pt)
KR (1) KR101398268B1 (pt)
CN (1) CN102574852B (pt)
AU (1) AU2010310786B2 (pt)
BR (1) BR112012011328A2 (pt)
CA (1) CA2778291C (pt)
EA (1) EA020151B1 (pt)
ES (1) ES2465094T3 (pt)
MX (1) MX2012004780A (pt)
WO (1) WO2011050016A1 (pt)

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CN104487430B (zh) 2012-05-17 2016-08-24 阵列生物制药公司 用于制造羟基化的环戊基嘧啶化合物的方法
CA2873663C (en) 2012-05-17 2020-01-14 Genentech, Inc. Amorphous form of an akt inhibiting pyrimidinyl-cyclopentane compound, compositions and methods thereof
PL2861582T3 (pl) * 2012-05-17 2016-11-30 Sposób wytwarzania hydroksylowanych związków cyklopentylopirymidynowych
SG11201407591PA (en) 2012-05-17 2015-01-29 Genentech Inc Process of making hydroxylated cyclopentapyrimidine compounds and salts thereof
CA2873658C (en) 2012-05-17 2021-01-26 Genentech, Inc. Process for making amino acid compounds
EP3299362B1 (en) * 2012-11-16 2020-04-22 Merck Patent GmbH Imidazol-piperidinyl derivatives as modulators of kinase activity
WO2014143612A1 (en) * 2013-03-11 2014-09-18 Merck Patent Gmbh 6-[4-(1 h-imidazol-2-yl)piperidin-1 -yl]pyrimidin-4-amine derivatives as modulators of kinase activity
US9974774B2 (en) 2013-07-26 2018-05-22 Race Oncology Ltd. Combinatorial methods to improve the therapeutic benefit of bisantrene and analogs and derivatives thereof
CA2922398C (en) 2013-09-12 2023-08-29 Dana-Farber Cancer Institute, Inc. Methods for evaluating and treating waldenstrom's macroglobulinemia
GB201401198D0 (en) * 2014-01-24 2014-03-12 Bial Portela & Ca Sa Process for the syntheis of substituted urea compounds
WO2015130585A1 (en) 2014-02-28 2015-09-03 Merck Sharp & Dohme Corp. Method for treating cancer
MA45048A (fr) * 2016-05-20 2019-03-27 Taiho Pharmaceutical Co Ltd Nouveau dérivé de 5h-pyrrolo[2,3-d]pyrimidin-6(7h)-one
JP2022517866A (ja) * 2019-01-29 2022-03-10 南京正大天晴制薬有限公司 Ａｋｔ阻害剤
CN115485276A (zh) * 2020-05-15 2022-12-16 南京正大天晴制药有限公司 氘代akt激酶抑制剂
WO2022017448A1 (zh) * 2020-07-22 2022-01-27 南京正大天晴制药有限公司 一种二氢吡啶并[2,3-d]嘧啶酮衍生物的盐及晶型
CN115836069B (zh) * 2020-07-22 2024-02-06 南京正大天晴制药有限公司 一种二氢吡啶并[2,3-d]嘧啶酮衍生物的盐、其制备方法及用途
CN115916350A (zh) * 2020-07-22 2023-04-04 南京正大天晴制药有限公司 Akt抑制剂的单位剂量组合物

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MXPA04007402A (es) 2002-02-01 2005-06-17 Ariad Gene Therapeutics Inc Compuestos que contienen fosforo y usos de los mismos.
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MY179032A (en) 2004-10-25 2020-10-26 Cancer Research Tech Ltd Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors
JP5111113B2 (ja) 2004-12-13 2012-12-26 サネシス ファーマシューティカルズ， インコーポレイテッド Ｒａｆキナーゼ阻害剤として有用なピリドピリミジノン、ジヒドロピリミドピリミジノンおよびプテリジノン
CA2590961C (en) * 2004-12-28 2013-11-26 Exelixis, Inc. [1h-pyrazolo[3,4-d]pyrimidin-4-yl]-piperidine or -piperazine compounds as serine-threonine kinase modulators (p70s6k, atk1 and atk2) for the treatment of immunological, inflammatory and proliferative diseases
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AR064416A1 (es) 2006-12-21 2009-04-01 Cancer Rec Tech Ltd Derivados de purina, piridina y pirimidina condensadas con heterociclos, moduladores de pka y/o pkb, composiciones farmaceuticas que los contienen, y usos para el tratamiento de enfermedades hiperproliferativas.
UA99284C2 (ru) 2007-05-11 2012-08-10 Елі Ліллі Енд Компані ИНГИБИТОРЫ р70 S6-КИНАЗЫ
AR074072A1 (es) * 2008-11-11 2010-12-22 Lilly Co Eli Compuesto de imidazol -piperidin -pirrol-pirimidin-6-ona, composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para tratar el glioblastoma multiforme

Also Published As

Publication number Publication date
JP2013508382A (ja) 2013-03-07
EP2491032A1 (en) 2012-08-29
US8436002B2 (en) 2013-05-07
CN102574852B (zh) 2014-06-25
CA2778291C (en) 2014-02-11
MX2012004780A (es) 2012-08-23
JP5581390B2 (ja) 2014-08-27
AU2010310786B2 (en) 2014-03-27
CN102574852A (zh) 2012-07-11
KR101398268B1 (ko) 2014-05-23
CA2778291A1 (en) 2011-04-28
EA020151B1 (ru) 2014-09-30
WO2011050016A1 (en) 2011-04-28
ES2465094T3 (es) 2014-06-05
EA201270590A1 (ru) 2012-09-28
KR20120068941A (ko) 2012-06-27
US20120149684A1 (en) 2012-06-14
EP2491032B1 (en) 2014-04-16
AU2010310786A1 (en) 2012-04-19

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]