EA201270308A1 - Конъюгаты димеров пирроло [1,4]бензодиазепина в качестве противоракового средства - Google Patents

Конъюгаты димеров пирроло [1,4]бензодиазепина в качестве противоракового средства

Info

Publication number
EA201270308A1
EA201270308A1 EA201270308A EA201270308A EA201270308A1 EA 201270308 A1 EA201270308 A1 EA 201270308A1 EA 201270308 A EA201270308 A EA 201270308A EA 201270308 A EA201270308 A EA 201270308A EA 201270308 A1 EA201270308 A1 EA 201270308A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pyrrolo
conjugates
cancer agent
benzodiazepine dimers
benzodiazepine
Prior art date
Application number
EA201270308A
Other languages
English (en)
Other versions
EA026488B1 (ru
Inventor
Ален Коммерсон
Лоранс Гози-Лазо
Original Assignee
Санофи
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Санофи filed Critical Санофи
Publication of EA201270308A1 publication Critical patent/EA201270308A1/ru
Publication of EA026488B1 publication Critical patent/EA026488B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/06—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00 containing at least one condensed beta-lactam ring system, provided for by groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00, e.g. a penem or a cepham system

Abstract

Изобретение относится к новым конъюгатам димеров пирроло[1,4]бензодиазепина (I), которые могут быть использованы в качестве противораковых средств.
EA201270308A 2009-08-25 2010-08-12 Конъюгаты димеров пирроло[1,4]бензодиазепина в качестве противоракового средства EA026488B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0904043A FR2949469A1 (fr) 2009-08-25 2009-08-25 Derives anticancereux, leur preparation et leur application en therapeutique
FR0904368A FR2949470B1 (fr) 2009-08-25 2009-09-11 Derives anticancereux, leur preparation et leur application therapeutique
PCT/FR2010/051709 WO2011023883A1 (fr) 2009-08-25 2010-08-12 Conjugues de dimeres de pyrrolo [1, 4 ] benzodiazepine en tant qu' anticancereux

Publications (2)

Publication Number Publication Date
EA201270308A1 true EA201270308A1 (ru) 2013-01-30
EA026488B1 EA026488B1 (ru) 2017-04-28

Family

ID=41720559

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201270308A EA026488B1 (ru) 2009-08-25 2010-08-12 Конъюгаты димеров пирроло[1,4]бензодиазепина в качестве противоракового средства

Country Status (33)

Country Link
US (2) US8481042B2 (ru)
EP (1) EP2470547B1 (ru)
JP (1) JP5889189B2 (ru)
KR (1) KR20130026405A (ru)
CN (1) CN102753559B (ru)
AR (1) AR078143A1 (ru)
AU (1) AU2010288382B2 (ru)
BR (1) BR112012004146A2 (ru)
CA (1) CA2772102C (ru)
CL (2) CL2012000489A1 (ru)
CO (1) CO6612210A2 (ru)
CR (1) CR20120085A (ru)
DO (1) DOP2012000038A (ru)
EA (1) EA026488B1 (ru)
EC (1) ECSP12011688A (ru)
ES (1) ES2484690T3 (ru)
FR (2) FR2949469A1 (ru)
GT (1) GT201200046A (ru)
HN (1) HN2012000437A (ru)
IL (1) IL218262A0 (ru)
MA (1) MA33600B1 (ru)
MX (1) MX2012002434A (ru)
MY (1) MY157469A (ru)
NI (1) NI201200031A (ru)
NZ (1) NZ598401A (ru)
PE (1) PE20120992A1 (ru)
SG (1) SG178537A1 (ru)
TN (1) TN2012000053A1 (ru)
TW (1) TWI477275B (ru)
UA (1) UA106507C2 (ru)
UY (1) UY32854A (ru)
WO (1) WO2011023883A1 (ru)
ZA (1) ZA201201397B (ru)

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9242013B2 (en) 2010-04-15 2016-01-26 Seattle Genetics Inc. Targeted pyrrolobenzodiazapine conjugates
US8697688B2 (en) 2010-04-15 2014-04-15 Seattle Genetics Inc. Pyrrolobenzodiazepines used to treat proliferative diseases
KR101860174B1 (ko) 2011-09-20 2018-05-21 메디뮨 리미티드 표적 접합체 내의 내포를 위한 비대칭 이량체 pbd 화합물로서 피롤로벤조디아제핀
MX341523B (es) 2011-10-14 2016-08-24 Medimmune Ltd Pirrolobenzodiazepinas.
JP6393617B2 (ja) 2011-10-14 2018-09-19 シアトル ジェネティクス，インコーポレーテッド ピロロベンゾジアゼピンおよび標的コンジュゲート
AU2012322932B2 (en) 2011-10-14 2016-11-10 Medimmune Limited Pyrrolobenzodiazepines
EP2753178B1 (en) 2011-10-14 2017-12-06 Seattle Genetics, Inc. Pyrrolobenzodiazepines and targeted conjugates
US9717803B2 (en) 2011-12-23 2017-08-01 Innate Pharma Enzymatic conjugation of polypeptides
US9504756B2 (en) 2012-05-15 2016-11-29 Seattle Genetics, Inc. Self-stabilizing linker conjugates
BR112014028222A2 (pt) 2012-05-15 2017-06-27 Seattle Genetics Inc conjugados vinculadores auto-estabilizantes.
EP2872894B1 (en) 2012-07-13 2019-04-17 Innate Pharma Screening of conjugated antibodies
CA2885315C (en) 2012-10-12 2020-06-23 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
ES2680153T3 (es) 2012-10-12 2018-09-04 Adc Therapeutics Sa Conjugados de anticuerpos anti-PSMA-pirrolobenzodiazepinas
RS53818B1 (en) 2012-10-12 2015-06-30 Spirogen Sàrl PIROLOBENZODIAZEPINI I NJIHOVI conjugated
KR101995621B1 (ko) 2012-10-12 2019-07-03 에이디씨 테라퓨틱스 에스에이 피롤로벤조디아제핀-항-cd22 항체 컨주게이트
CA2887895C (en) 2012-10-12 2019-10-29 Adc Therapeutics Sarl Pyrrolobenzodiazepine-anti-cd19 antibody conjugates
WO2014057120A1 (en) 2012-10-12 2014-04-17 Adc Therapeutics Sàrl Pyrrolobenzodiazepine-antibody conjugates
JP6367204B2 (ja) 2012-10-12 2018-08-01 メドイミューン・リミテッドＭｅｄＩｍｍｕｎｅ Ｌｉｍｉｔｅｄ 結合用のピロロベンゾジアゼピン誘導体の合成および中間体
PT2906296T (pt) 2012-10-12 2018-06-01 Medimmune Ltd Conjugados de pirrolobenzodiazepina-anticorpo
JP6270859B2 (ja) 2012-10-12 2018-01-31 エイディーシー・セラピューティクス・エス・アー・エール・エルＡｄｃ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｓａｒｌ ピロロベンゾジアゼピン−抗体結合体
US10036010B2 (en) 2012-11-09 2018-07-31 Innate Pharma Recognition tags for TGase-mediated conjugation
JP6340019B2 (ja) 2013-03-13 2018-06-06 メドイミューン・リミテッドＭｅｄＩｍｍｕｎｅ Ｌｉｍｉｔｅｄ ピロロベンゾジアゼピン及びそのコンジュゲート
KR102057755B1 (ko) * 2013-03-13 2019-12-19 메디뮨 리미티드 피롤로벤조디아제핀 및 그의 컨쥬게이트
ES2843786T3 (es) 2013-03-13 2021-07-20 Seagen Inc Filtración con carbono activado para la purificación de ADC de benzodiazepina
WO2014140300A1 (en) 2013-03-15 2014-09-18 Innate Pharma Solid phase tgase-mediated conjugation of antibodies
US10071169B2 (en) 2013-06-20 2018-09-11 Innate Pharma Enzymatic conjugation of polypeptides
AU2014283185B2 (en) 2013-06-21 2019-05-02 Innate Pharma Enzymatic conjugation of polypeptides
US9950078B2 (en) 2013-10-11 2018-04-24 Medimmune Limited Pyrrolobenzodiazepine-antibody conjugates
US9956299B2 (en) 2013-10-11 2018-05-01 Medimmune Limited Pyrrolobenzodiazepine—antibody conjugates
GB201317981D0 (en) 2013-10-11 2013-11-27 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
EP3054983B1 (en) 2013-10-11 2019-03-20 Medimmune Limited Pyrrolobenzodiazepine-antibody conjugates
HUE051389T2 (hu) 2013-10-15 2021-03-01 Seagen Inc Pegilezett gyógyszer-linkerek ligandum-gyógyszer konjugátum javított farmakokinetikájához
FI3082878T3 (fi) 2013-12-19 2022-12-15 Metyleenikarbamaatin linkkerit käytettäviksi kohdennettujen lääkeaineiden konjugaattien kanssa
MX2016010295A (es) 2014-02-11 2016-10-17 Seattle Genetics Inc Reduccion selectiva de proteinas.
WO2016008112A1 (en) 2014-07-16 2016-01-21 Medshine Discovery Inc. Linkers and application towards adc thereof
DK3191135T3 (da) 2014-09-12 2020-10-12 Genentech Inc Anti-HER2-antistoffer og immunokonjugater
GB201416112D0 (en) 2014-09-12 2014-10-29 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
JP6730261B2 (ja) * 2014-09-17 2020-07-29 ジェネンテック， インコーポレイテッド 抗ｈｅｒ２抗体を含む免疫複合体
EP3223854A1 (en) 2014-11-25 2017-10-04 ADC Therapeutics SA Pyrrolobenzodiazepine-antibody conjugates
MX2017009144A (es) 2015-01-14 2017-11-22 Bristol Myers Squibb Co Dimeros de benzodiazepina unidos con puentes de heteroarileno, conjugados de estos, y sus metodos de preparacion y uso.
WO2016115191A1 (en) 2015-01-14 2016-07-21 Bristol-Myers Squibb Company Benzodiazepine dimers, conjugates thereof, and methods of making and using
GB201506402D0 (en) 2015-04-15 2015-05-27 Berkel Patricius H C Van And Howard Philip W Site-specific antibody-drug conjugates
GB201506411D0 (en) 2015-04-15 2015-05-27 Bergenbio As Humanized anti-axl antibodies
KR20180019592A (ko) 2015-06-23 2018-02-26 브리스톨-마이어스 스큅 컴퍼니 마크로시클릭 벤조디아제핀 이량체, 그의 접합체, 제조법 및 용도
MA43345A (fr) 2015-10-02 2018-08-08 Hoffmann La Roche Conjugués anticorps-médicaments de pyrrolobenzodiazépine et méthodes d'utilisation
GB201601431D0 (en) 2016-01-26 2016-03-09 Medimmune Ltd Pyrrolobenzodiazepines
GB201602356D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201602359D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
SG11201807827VA (en) 2016-03-25 2018-10-30 Seattle Genetics Inc Process for the preparation of pegylated drug-linkers and intermediates thereof
GB201607478D0 (en) 2016-04-29 2016-06-15 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
CN109562152B (zh) 2016-08-09 2024-04-02 西雅图基因公司 含有具有改善的生理化学性质的自稳定性接头的药物缀合物
GB201617466D0 (en) 2016-10-14 2016-11-30 Medimmune Ltd Pyrrolobenzodiazepine conjugates
JP7244987B2 (ja) 2016-12-14 2023-03-23 シージェン インコーポレイテッド 多剤抗体薬物コンジュゲート
CA3046548A1 (en) 2017-01-24 2018-08-02 Innate Pharma Nkp46 binding agents
EP3577138A1 (en) 2017-02-06 2019-12-11 Innate Pharma Immunomodulatory antibody drug conjugates binding to a human mica polypeptide
GB201702031D0 (en) 2017-02-08 2017-03-22 Medlmmune Ltd Pyrrolobenzodiazepine-antibody conjugates
US11160872B2 (en) 2017-02-08 2021-11-02 Adc Therapeutics Sa Pyrrolobenzodiazepine-antibody conjugates
JP2020512312A (ja) 2017-03-24 2020-04-23 シアトル ジェネティックス， インコーポレイテッド グルクロニド薬物−リンカーの調製のためのプロセスおよびその中間体
CN110582505B (zh) 2017-04-18 2021-04-02 免疫医疗有限公司 吡咯并苯并二氮杂*缀合物
CN110536703A (zh) 2017-04-20 2019-12-03 Adc治疗有限公司 使用抗axl抗体-药物缀合物的组合疗法
US11318211B2 (en) 2017-06-14 2022-05-03 Adc Therapeutics Sa Dosage regimes for the administration of an anti-CD19 ADC
SI3668874T1 (sl) 2017-08-18 2022-04-29 Medimmune Limited Pirolobenzodiazepinski konjugati
CN116999573A (zh) 2017-09-29 2023-11-07 第一三共株式会社 抗体－药物偶联物及其制造方法、药物组合物及其在制备***的药物中的应用
WO2019092148A1 (en) 2017-11-10 2019-05-16 Innate Pharma Antibodies with functionalized glutamine residues
GB201803342D0 (en) 2018-03-01 2018-04-18 Medimmune Ltd Methods
GB201806022D0 (en) * 2018-04-12 2018-05-30 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
EP4036149A4 (en) 2019-09-26 2023-10-25 NOF Corporation HETEROBIFUNCTIONAL MONODISPERSPERED POLYETHYLENE GLYCOL WITH PEPTIDE LINKER
CA3176248A1 (en) 2020-04-10 2021-10-14 Seagen Inc. Charge variant linkers
WO2022112356A1 (en) 2020-11-25 2022-06-02 Innate Pharma Treatment of cancer
JP2024510435A (ja) 2021-03-18 2024-03-07 シージェン インコーポレイテッド 生体活性化合物の内部移行複合体からの選択的薬物放出
KR20230158006A (ko) 2021-03-18 2023-11-17 씨젠 인크. 생물학적 활성 화합물의 내재화된 접합체로부터의 선택적 약물 방출
WO2023227660A1 (en) 2022-05-25 2023-11-30 Innate Pharma Nectin-4 binding agents

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1516743A (fr) 1966-04-01 1968-02-05 Rhone Poulenc Sa Nouvel antibiotique et son procédé de préparation par culture de streptomyces croceus
GB8307865D0 (en) * 1983-03-22 1983-04-27 Fujisawa Pharmaceutical Co Benzimidazole derivatives
GB9205051D0 (en) * 1992-03-09 1992-04-22 Cancer Res Campaign Tech Pyrrolobenzodiazepine derivatives,their preparation,and compositions containing them
KR19990029749A (ko) * 1997-09-17 1999-04-26 미우라 아끼라 2가 반응성 수용성 고분자 유도체 및 이들을 함유하는 복합체
EP1193270B1 (en) * 1998-08-27 2003-05-14 Spirogen Limited Pyrrolobenzodiazepines
GB9818731D0 (en) 1998-08-27 1998-10-21 Univ Portsmouth Compounds
KR100743212B1 (ko) * 2001-06-08 2007-07-26 소시에떼 더 콘세이유 더 레세르세 에 다플리까띠옹 시엔띠피끄, 에스.아.에스. 소마토스타틴-도파민 키메라 유사체
US6716821B2 (en) 2001-12-21 2004-04-06 Immunogen Inc. Cytotoxic agents bearing a reactive polyethylene glycol moiety, cytotoxic conjugates comprising polyethylene glycol linking groups, and methods of making and using the same
US7230101B1 (en) 2002-08-28 2007-06-12 Gpc Biotech, Inc. Synthesis of methotrexate-containing heterodimeric molecules
AU2003285878B2 (en) 2002-11-07 2011-04-28 Immunogen, Inc. Anti-CD33 antibodies and method for treatment of acute myeloid leukemia using the same
EP3851126A1 (en) 2003-05-20 2021-07-21 ImmunoGen, Inc. Maytansinoid-cell-binding agent conjugates
WO2005009369A2 (en) 2003-07-21 2005-02-03 Immunogen, Inc. A ca6 antigen-specific cytotoxic conjugate and methods of using the same
AU2004284075A1 (en) 2003-10-22 2005-05-06 Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Pyrrolobenzodiazepine derivatives, compositions comprising the same and methods related thereto
WO2005085260A1 (en) 2004-03-09 2005-09-15 Spirogen Limited Pyrrolobenzodiazepines
EP1669358A1 (en) 2004-12-07 2006-06-14 Aventis Pharma S.A. Cytotoxic agents comprising new taxanes
MX2007007590A (es) 2004-12-22 2007-12-10 Ambrx Inc Composiciones que contienen, metodos que involucran y usos de aminoacidos no naturales y polipeptidos.
PL1945647T3 (pl) * 2005-11-08 2012-04-30 Immunogen Inc Procesy wytwarzania maytansinolu
PT1813614E (pt) * 2006-01-25 2012-01-09 Sanofi Sa Agentes citotóxicos compreendendo novos derivados de tomaimicina
EP1832577A1 (en) 2006-03-07 2007-09-12 Sanofi-Aventis Improved prodrugs of CC-1065 analogs
EP2010475A2 (en) 2006-04-27 2009-01-07 Intezyne Technologies Incorporated Heterofunctional poly(ethylene glycol) containing acid-labile amino protecting groups and uses thereof
EP1864682A1 (en) 2006-06-09 2007-12-12 Sanofi-Aventis Leptomycin derivatives
KR101528939B1 (ko) 2006-07-18 2015-06-15 사노피 암 치료를 위한 ｅｐｈａ2에 대한 길항제 항체
EP1914242A1 (en) 2006-10-19 2008-04-23 Sanofi-Aventis Novel anti-CD38 antibodies for the treatment of cancer
SI2019104T1 (sl) * 2007-07-19 2013-12-31 Sanofi Citotoksična sredstva, ki obsegajo nove tomaimicinske derivate, in njihova terapevtska uporaba
EP2185188B1 (en) 2007-08-22 2014-08-06 Medarex, L.L.C. Site-specific attachment of drugs or other agents to engineered antibodies with c-terminal extensions
EP2276506A4 (en) * 2008-04-30 2014-05-07 Immunogen Inc EFFICIENT CONJUGATES AND HYDROPHILIC BINDER
IL271761B (en) * 2009-02-05 2022-09-01 Immunogen Inc (12as)-8-methoxy-9-benzyloxy-11,12,12a,13-tetrahydro-6h-indolo[2,1-c][1,4]benzodiazepine-6-one, 4-benzyloxy-5-methoxy -2-nitrobenzoic acid and a process for their preparation
AR078471A1 (es) * 2009-10-02 2011-11-09 Sanofi Aventis COMPUESTOS MAITANSINOIDES Y EL USO DE ESTOS PARA PREPARAR CONJUGADOS CON UN ANTICUERPO LOS CUALES SE UTILIZAN COMO AGENTES ANTICANCERIGENOS Y EL PROCEDIMIENTO DE PREPARACIoN DE ESTOS CONJUGADOS
FR2963007B1 (fr) * 2010-07-26 2013-04-05 Sanofi Aventis Derives anticancereux, leur preparation et leur application therapeutique

Also Published As

Publication number Publication date
TWI477275B (zh) 2015-03-21
CA2772102A1 (fr) 2011-03-03
NZ598401A (en) 2014-03-28
CR20120085A (es) 2012-06-01
NI201200031A (es) 2013-09-18
JP5889189B2 (ja) 2016-03-22
WO2011023883A1 (fr) 2011-03-03
CO6612210A2 (es) 2013-02-01
ECSP12011688A (es) 2012-03-30
PE20120992A1 (es) 2012-08-22
UA106507C2 (ru) 2014-09-10
CN102753559B (zh) 2015-11-25
ZA201201397B (en) 2013-05-29
MY157469A (en) 2016-06-15
EP2470547B1 (fr) 2014-05-14
FR2949469A1 (fr) 2011-03-04
FR2949470A1 (fr) 2011-03-04
EP2470547A1 (fr) 2012-07-04
JP2013503143A (ja) 2013-01-31
ES2484690T3 (es) 2014-08-12
BR112012004146A2 (pt) 2017-05-30
AU2010288382A1 (en) 2012-03-15
CN102753559A (zh) 2012-10-24
AU2010288382B2 (en) 2015-10-22
CL2012000489A1 (es) 2012-08-03
IL218262A0 (en) 2012-04-30
KR20130026405A (ko) 2013-03-13
US20140155590A1 (en) 2014-06-05
CL2013001609A1 (es) 2013-11-04
SG178537A1 (en) 2012-03-29
HN2012000437A (es) 2015-03-02
TW201119657A (en) 2011-06-16
CA2772102C (fr) 2018-09-04
MX2012002434A (es) 2012-07-20
TN2012000053A1 (fr) 2013-09-19
US8481042B2 (en) 2013-07-09
MA33600B1 (fr) 2012-09-01
DOP2012000038A (es) 2012-06-15
EA026488B1 (ru) 2017-04-28
GT201200046A (es) 2014-09-26
FR2949470B1 (fr) 2011-11-04
AR078143A1 (es) 2011-10-19
UY32854A (es) 2011-03-31
US20120244172A1 (en) 2012-09-27

Similar Documents

Publication Publication Date Title
EA201270308A1 (ru) Конъюгаты димеров пирроло [1,4]бензодиазепина в качестве противоракового средства
UY33801A (es) COMPUESTOS SUSTITUIDOS DE N-(1H-INDAZOL-4IL)IMIDAZO[1,2-a]PIRIDIN-3-CARBOXAMIDA COMO INHIBIDORES DE LA TIROSINA QUINASA RECEPTORA DE TIPO III
MX2010009646A (es) Agentes terapeuticos antivirales.
MA33803B1 (fr) Inhibiteur de bromodomaine de benzodiazépine
JO2788B1 (en) Amido phenoxyendazole compounds beneficial as C-MET inhibitors
EA201171367A1 (ru) Винилиндазолильные соединения
EA201170227A1 (ru) Имидазолкарбоксамиды
EA201270619A1 (ru) Применение бетанехола для лечения ксеростомии
MY170878A (en) [1,2,3] triazolo [4,5-d] pyrimidine derivatives as agonists of the cannabinoid receptor 2
UY33936A (es) Derivados de fluoro-piridinona útiles como agentesantibacterianos.
MX2011014019A (es) Derivados de diazahomoadamantano y sus metodos de uso.
GB2437009A (en) Ranking system
TW200942524A (en) Novel aminomethyl benzene derivatives
MX346248B (es) Derivados de [1,2,3]triazol[4,5-d]pirimidina como agonistas de los agonistas del receptor canabinoide 2.
TW200942530A (en) Pyridine compounds
CO6241120A2 (es) (DIHIDRO)PIRROLO[2,1-á]ISOQUINOLINAS.
SV2009003429A (es) Derivados de 7-alquinil-1,8-naftiridonas, su preparacion y su aplicacion en terapeutica
EA201101116A1 (ru) Фармацевтические композиции, включающие производные 2-оксо-1-пирролидина
MA35816B1 (fr) Dérivés d'aniline, leur préparation et leur application thérapeutique
BR112012019302A2 (pt) imidazo[1,2-b][1,2,4]triazinas como inibidores de c-met
MA34840B1 (fr) Dérivés monoterpènes de chalcone ou de dihydrochalcone, et leur utilisation en tant qu'agents de dépigmentation
EP2576575A4 (en) PROSTAGLANDIN-BISPHOSPHONATE CONJUGATE COMPOUNDS, THEIR METHODS OF MANUFACTURE AND USES THEREOF
TR201109686T2 (tr) Olmesartan'ın Farmasötik Bileşimleri.
MA33932B1 (fr) Dérivés de 2-aldoximino-5-fluoropyrimidine
UA35660U (en) Use of antihomotoxic preparations as cytoprotectors

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU