EA201190143A1 - Сочлененные производные пиримидиндионов в качестве модуляторов trpa1 - Google Patents

Сочлененные производные пиримидиндионов в качестве модуляторов trpa1

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Publication number
EA201190143A1
EA201190143A1 EA201190143A EA201190143A EA201190143A1 EA 201190143 A1 EA201190143 A1 EA 201190143A1 EA 201190143 A EA201190143 A EA 201190143A EA 201190143 A EA201190143 A EA 201190143A EA 201190143 A1 EA201190143 A1 EA 201190143A1
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Eurasian Patent Office
Prior art keywords
trpa1
pyrimidindions
jointed
derivatives
subfamily
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EA201190143A
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English (en)
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EA023857B1 (ru
Inventor
Сачин Сундарлал Чаудхари
Сукеерти Кумар
Абрахам Томас
Ниша Параг Патил
Ашок Бхаусахеб Кадам
Вишал Говиндрао Дешмух
Сачин Васантрао Дхоне
Раджентра Пракаш Чикхале
Неелима Кхайраткар-Джоши
Индранил Мухопадхяй
Original Assignee
Гленмарк Фармасеутикалс С.А.
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Application filed by Гленмарк Фармасеутикалс С.А. filed Critical Гленмарк Фармасеутикалс С.А.
Publication of EA201190143A1 publication Critical patent/EA201190143A1/ru
Publication of EA023857B1 publication Critical patent/EA023857B1/ru

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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract

В заявке описаны новые сочлененные производные пиримидиндионов формулы (I), которые являются модуляторами TRPA (действующего по механизму транзиторного рецепторного потенциала подсемейства А). В частности, описаны соединения, применимые для лечения или профилактики заболеваний, состояний и(или) нарушений, модулируемых TRPA1 (членом 1 действующего по механизму транзиторного рецепторного потенциала подсемейства А). Также описаны способы получения предложенных соединений, используемых для их синтеза промежуточных соединений, их фармацевтических композиций и способов лечения или профилактики заболеваний, состояний и(или) нарушений, модулируемых TRPA1.
EA201190143A 2009-03-23 2010-03-17 Сочлененные производные пиримидиндионов в качестве модуляторов trpa1 EA023857B1 (ru)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
IN665MU2009 2009-03-23
US17135509P 2009-04-21 2009-04-21
IN2211MU2009 2009-09-23
IN2212MU2009 2009-09-23
US25194409P 2009-10-15 2009-10-15
US25326309P 2009-10-20 2009-10-20
IN2891MU2009 2009-12-15
IN2892MU2009 2009-12-15
US29446310P 2010-01-12 2010-01-12
US30024110P 2010-02-01 2010-02-01
PCT/IB2010/000553 WO2010109287A1 (en) 2009-03-23 2010-03-17 Fused pyrimidine-dione derivatives as trpa1 modulators

Publications (2)

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EA201190143A1 true EA201190143A1 (ru) 2012-04-30
EA023857B1 EA023857B1 (ru) 2016-07-29

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US (1) US9000159B2 (ru)
EP (2) EP2411393B1 (ru)
JP (1) JP5657638B2 (ru)
KR (1) KR20110132575A (ru)
CN (1) CN102361873B (ru)
AP (1) AP3280A (ru)
AU (1) AU2010227245B2 (ru)
BR (1) BRPI1013559A2 (ru)
CA (1) CA2756518A1 (ru)
CL (2) CL2011002315A1 (ru)
DK (1) DK2411393T3 (ru)
EA (1) EA023857B1 (ru)
ES (2) ES2551085T3 (ru)
HK (2) HK1166075A1 (ru)
IL (1) IL215178A (ru)
MX (1) MX2011009824A (ru)
PE (1) PE20120774A1 (ru)
PL (1) PL2411393T3 (ru)
PT (1) PT2411393E (ru)
SG (1) SG174402A1 (ru)
SI (1) SI2411393T1 (ru)
UA (1) UA108069C2 (ru)
WO (1) WO2010109287A1 (ru)
ZA (1) ZA201107648B (ru)

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US20140128603A1 (en) 2014-05-08
EP2411393A4 (en) 2012-08-01
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IL215178A (en) 2015-01-29
AU2010227245A1 (en) 2011-09-22
UA108069C2 (ru) 2015-03-25
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