EA201170237A1 - Производные карбаматов алкилтиазолов, их получение и их применение в терапии - Google Patents

Производные карбаматов алкилтиазолов, их получение и их применение в терапии

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Publication number
EA201170237A1
EA201170237A1 EA201170237A EA201170237A EA201170237A1 EA 201170237 A1 EA201170237 A1 EA 201170237A1 EA 201170237 A EA201170237 A EA 201170237A EA 201170237 A EA201170237 A EA 201170237A EA 201170237 A1 EA201170237 A1 EA 201170237A1
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EA
Eurasian Patent Office
Prior art keywords
therapy
atom
alkiltiazoles
receiving
carbamate derivatives
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EA201170237A
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English (en)
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EA018995B1 (ru
Inventor
Ахмед Абуабделла
Йохен Герлитцер
Питер Хэмли
Антуан Раве
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Санофи-Авентис
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Publication of EA201170237A1 publication Critical patent/EA201170237A1/ru
Publication of EA018995B1 publication Critical patent/EA018995B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Abstract

Соединение общей формулы (I)в которой Rобозначает атом водорода, фтора или гидроксильную, циано, трифторметильную, C-алкильную, C-алкоксигруппу, NRR; n обозначает целое число, равное 1, 2 или 3, и m обозначает целое число, равное 1 или 2; А обозначает ковалентную связь или C-алкилен; Rгруппу типа арильной или гетероарильной, возможно замещенной, Rобозначает атом водорода, фтора, C-алкил или трифторметил; Rобозначает тиазол, возможно замещенный; в виде основания или соли присоединения с кислотой. Применение в терапии.
EA201170237A 2008-07-23 2009-07-21 Производные карбаматов алкилтиазолов, их получение и их применение в терапии EA018995B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0804179A FR2934265B1 (fr) 2008-07-23 2008-07-23 Derives de carbamates d'alkylthiazoles, leur preparation et leur application en therapeutique
PCT/FR2009/051457 WO2010010288A2 (fr) 2008-07-23 2009-07-21 Derives de carbamates d'alkylthiazoles, leur preparation et leur application en therapeutique

Publications (2)

Publication Number Publication Date
EA201170237A1 true EA201170237A1 (ru) 2011-10-31
EA018995B1 EA018995B1 (ru) 2013-12-30

Family

ID=40289184

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201170237A EA018995B1 (ru) 2008-07-23 2009-07-21 Производные карбаматов алкилтиазолов, их получение и их применение в терапии

Country Status (28)

Country Link
US (1) US8912218B2 (ru)
EP (1) EP2344486B1 (ru)
JP (1) JP5452594B2 (ru)
KR (1) KR20110034020A (ru)
CN (1) CN102164920B (ru)
AR (1) AR072593A1 (ru)
AU (1) AU2009274355B2 (ru)
BR (1) BRPI0916385A2 (ru)
CA (1) CA2731789C (ru)
CL (1) CL2011000147A1 (ru)
CO (1) CO6351789A2 (ru)
CY (1) CY1114519T1 (ru)
DK (1) DK2344486T3 (ru)
EA (1) EA018995B1 (ru)
ES (1) ES2413304T3 (ru)
FR (1) FR2934265B1 (ru)
HR (1) HRP20130585T1 (ru)
IL (1) IL210747A0 (ru)
MA (1) MA32579B1 (ru)
MX (1) MX2011000882A (ru)
PE (1) PE20110384A1 (ru)
PL (1) PL2344486T3 (ru)
PT (1) PT2344486E (ru)
SI (1) SI2344486T1 (ru)
SM (1) SMT201300080B (ru)
TW (1) TW201008937A (ru)
UY (1) UY32004A (ru)
WO (1) WO2010010288A2 (ru)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2938537B1 (fr) * 2008-11-14 2012-10-26 Sanofi Aventis Derives de carbamates d'alkyl-heterocycles, leur preparation et leur application en therapeutique.
FR2941696B1 (fr) * 2009-02-05 2011-04-15 Sanofi Aventis Derives d'azaspiranyl-alkylcarbamates d'heterocycles a 5 chainons, leur preparation et leur application en therapeutique
FR2945533B1 (fr) * 2009-05-12 2011-05-27 Sanofi Aventis Derives de cyclopenta°c!pyrrolyl-alkylcarbamates d'heterocycles a 5 chainons, leur preparation et leur application en therapeutique
FR2945534B1 (fr) * 2009-05-12 2012-11-16 Sanofi Aventis DERIVES DE CYCLOPENTAL[c]PYRROLE-2-CARBOXYLATES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
US20130150346A1 (en) 2010-01-08 2013-06-13 Quest Ventures Ltd. Use of FAAH Inhibitors for Treating Parkinson's Disease and Restless Legs Syndrome
US20130224151A1 (en) 2010-03-31 2013-08-29 United States Of America Use of FAAH Inhibitors for Treating Abdominal, Visceral and Pelvic Pain
BR112013006016A2 (pt) 2010-09-15 2016-06-07 Hoffmann La Roche compostos de azabenzotiazol, composições e métodos de uso
DE102012018115A1 (de) 2012-09-13 2014-03-13 Matthias Lehr Aryl-N-(arylalkyl)carbamate als Hemmstoffe der Fatty Acid Amide Hydrolase
DE102013016573A1 (de) 2013-10-04 2015-04-09 Matthias Lehr 1-Tetrazolylpropan-2-one als Inhibitoren von cytosolischer Phospholipase A2 und Fatty Acid Amide Hydrolase, insbesondere geeignet zur topischen Anwendung
WO2020048831A1 (en) 2018-09-03 2020-03-12 Bayer Aktiengesellschaft 5-aryl-3,9-diazaspiro[5.5]undecan-2-one compounds
WO2020048830A1 (en) 2018-09-03 2020-03-12 Bayer Aktiengesellschaft 5-aryl-3,9-diazaspiro[5.5]undecan-2-one compounds
WO2020048828A1 (en) 2018-09-03 2020-03-12 Bayer Pharma Aktiengesellschaft 5-heteroaryl-3,9-diazaspiro[5.5]undecane compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2854633B1 (fr) * 2003-05-07 2005-06-24 Sanofi Synthelabo Derives de piperidinyl-et piperazinyl-alkylcarbamates, leur preparation et leur application en therapeutique
GB0417801D0 (en) * 2004-08-10 2004-09-15 Novartis Ag Organic compounds
EP1780210A4 (en) * 2004-08-11 2009-06-10 Kyorin Seiyaku Kk NEW CYCLIC AMINOBENOIC ACID DERIVATIVE
CL2008001933A1 (es) * 2007-06-29 2009-09-25 Millennium Pharm Inc Compuestos derivados de pirimidina, inhibidores de la raf quinasa; compuestos intermediarios; procedimiento de preparacion; composicion farmaceutica; y su uso para tratar trastornos proliferativos, cardiacos, neurodegenerativos, inflamatorios, oseos, inmunologicos enfermedad viral, entre otros.
FR2938537B1 (fr) * 2008-11-14 2012-10-26 Sanofi Aventis Derives de carbamates d'alkyl-heterocycles, leur preparation et leur application en therapeutique.

Also Published As

Publication number Publication date
PT2344486E (pt) 2013-06-27
WO2010010288A2 (fr) 2010-01-28
FR2934265B1 (fr) 2010-07-30
JP5452594B2 (ja) 2014-03-26
CY1114519T1 (el) 2016-10-05
CA2731789A1 (fr) 2010-01-28
DK2344486T3 (da) 2013-07-08
WO2010010288A3 (fr) 2010-03-18
AU2009274355A1 (en) 2010-01-28
CA2731789C (fr) 2016-08-30
SI2344486T1 (sl) 2013-07-31
UY32004A (es) 2010-02-26
TW201008937A (en) 2010-03-01
CN102164920A (zh) 2011-08-24
HRP20130585T1 (en) 2013-07-31
EP2344486B1 (fr) 2013-03-27
PL2344486T3 (pl) 2013-08-30
US20110212963A1 (en) 2011-09-01
PE20110384A1 (es) 2011-07-01
MA32579B1 (fr) 2011-08-01
FR2934265A1 (fr) 2010-01-29
EA018995B1 (ru) 2013-12-30
CO6351789A2 (es) 2011-12-20
SMT201300080B (it) 2013-09-06
MX2011000882A (es) 2011-03-01
AU2009274355B2 (en) 2014-01-30
US8912218B2 (en) 2014-12-16
IL210747A0 (en) 2011-03-31
EP2344486A2 (fr) 2011-07-20
BRPI0916385A2 (pt) 2018-06-05
JP2011528704A (ja) 2011-11-24
AR072593A1 (es) 2010-09-08
CN102164920B (zh) 2013-12-25
ES2413304T3 (es) 2013-07-16
KR20110034020A (ko) 2011-04-04
CL2011000147A1 (es) 2011-06-17

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