EA201070010A1 - Производные 7-алкинил-1,8-нафтиридонов, их получение и их применение в терапии - Google Patents

Производные 7-алкинил-1,8-нафтиридонов, их получение и их применение в терапии

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Publication number
EA201070010A1
EA201070010A1 EA201070010A EA201070010A EA201070010A1 EA 201070010 A1 EA201070010 A1 EA 201070010A1 EA 201070010 A EA201070010 A EA 201070010A EA 201070010 A EA201070010 A EA 201070010A EA 201070010 A1 EA201070010 A1 EA 201070010A1
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EA
Eurasian Patent Office
Prior art keywords
therapy
alkyl group
naftyridones
alkinyl
derivatives
Prior art date
Application number
EA201070010A
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English (en)
Other versions
EA016552B1 (ru
Inventor
Антуан Алам
Франсуаз Боно
Оливье Дюкло
Гари Мак Корт
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Санофи-Авентис
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Publication of EA201070010A1 publication Critical patent/EA201070010A1/ru
Publication of EA016552B1 publication Critical patent/EA016552B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings

Abstract

Изобретение касается соединений, отвечающих формуле (I), в которой Rи Rобозначают независимо один от другого атом водорода, (С1-С7)алкильную группу, в известных случаях замещенную одной или несколькими алкоксигруппами; Rобозначает (С1-С7)алкильную группу; Rобозначает атом водорода, (С1-С4)алкильную группу; Y обозначает (С1-С4)алкоксигруппу, группу -NRR', -О(CH)-C(О)-NRR, где R и R' являются такими, как определенные ниже, и n представляет собой целое число, равное 1 или 2; R" обозначает (С1-С4) алкильную группу и R и R' обозначают независимо один от другого атом водорода, группу -СО-(С1-С4)алкил или группу -COOR", где R" является таким, как определенный выше. Способ получения и применение в терапии.
EA201070010A 2007-06-13 2008-06-11 Производные 7-алкинил-1,8-нафтиридонов, их получение и их применение в терапии EA016552B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0704193A FR2917413B1 (fr) 2007-06-13 2007-06-13 Derives de 7-alkynyl-1,8-naphthyridones, leur preparation et leur application en therapeutique
PCT/FR2008/000794 WO2009007536A2 (fr) 2007-06-13 2008-06-11 Dérivés de 7 -alkynyl-1,8-naphthyridones, leur préparation et leur application en thérapeutique

Publications (2)

Publication Number Publication Date
EA201070010A1 true EA201070010A1 (ru) 2010-06-30
EA016552B1 EA016552B1 (ru) 2012-05-30

Family

ID=38961501

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201070010A EA016552B1 (ru) 2007-06-13 2008-06-11 Производные 7-алкинил-1,8-нафтиридонов, их получение и их применение в терапии

Country Status (29)

Country Link
US (2) US8263614B2 (ru)
EP (1) EP2158194B1 (ru)
JP (1) JP5346337B2 (ru)
KR (1) KR20100019507A (ru)
CN (1) CN101815715B (ru)
AR (1) AR066955A1 (ru)
AT (1) ATE509923T1 (ru)
AU (1) AU2008274100B2 (ru)
BR (1) BRPI0813809B1 (ru)
CA (1) CA2690349C (ru)
CO (1) CO6150157A2 (ru)
CY (1) CY1111748T1 (ru)
DK (1) DK2158194T3 (ru)
EA (1) EA016552B1 (ru)
ES (1) ES2366629T3 (ru)
FR (1) FR2917413B1 (ru)
HK (1) HK1143590A1 (ru)
HR (1) HRP20110550T1 (ru)
IL (1) IL202677A (ru)
IN (1) IN2009KN04279A (ru)
MA (1) MA31674B1 (ru)
ME (1) ME00957B (ru)
MX (1) MX2009013514A (ru)
MY (1) MY146939A (ru)
NZ (1) NZ581883A (ru)
PL (1) PL2158194T3 (ru)
PT (1) PT2158194E (ru)
SI (1) SI2158194T1 (ru)
WO (1) WO2009007536A2 (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2917412B1 (fr) * 2007-06-13 2009-08-21 Sanofi Aventis Sa Derives de 7-alkynyl, 1,8-naphthyridones, leur preparation et leur application en therapeutique
WO2009075841A2 (en) 2007-12-10 2009-06-18 Sunesis Pharmaceuticals, Inc. Methods of using (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of antecedent hematologic disorders
FR2933700B1 (fr) 2008-07-08 2010-07-30 Sanofi Aventis Derives de pyridino-pyridinones, leur preparation et leur application en therapeutique
FR2952934B1 (fr) * 2009-11-23 2012-06-22 Sanofi Aventis Derives de pyridino-pyridinones, leur preparation et leur application en therapeutique
FR2954943B1 (fr) * 2010-01-07 2013-03-01 Sanofi Aventis Derives de pyridino-pyridinones arylsulfonamides, leur preparation et leur application en therapeutique
FR2955109B1 (fr) * 2010-01-08 2012-09-07 Sanofi Aventis Derives de 5-oxo-5,8-dihydro-pyrido[2, 3-d]pyrimidine, leur preparation et leur application en therapeutique
US20130210733A1 (en) * 2010-06-17 2013-08-15 Cytokinetics, Inc. Methods of treating lung disease
WO2013072882A1 (en) * 2011-11-18 2013-05-23 Actelion Pharmaceuticals Ltd 2 -amino- 1, 8 -naphthyridine-3 -carboxamide derivatives as antimicrobial agents

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU695132B2 (en) 1995-08-02 1998-08-06 Darwin Discovery Limited Quinolones and their therapeutic use
WO1999038867A1 (fr) 1998-01-29 1999-08-05 Suntory Limited Derives de 1-cycloalkyle-1,8-naphthyridine-4-one presentant une activite inhibitrice de la phosphodiesterase iv
DE19826050A1 (de) * 1998-06-12 1999-12-16 Bayer Ag Verfahren zur Herstellung von Chinolon- und Naphthyridoncarbonsäuren und deren Ester
IL158783A0 (en) 2001-05-08 2004-05-12 Schering Ag Selective anthranilamide pyridine amides as inhibitors of vegfr-2 and vegfr-3
AU2002257459B2 (en) 2001-05-24 2006-12-14 Merck Frosst Canada Ltd 1-biaryl-1,8-napthyridin-4-one phosphodiesterase-4 inhibitors
US7148357B2 (en) 2002-07-31 2006-12-12 Schering Ag VEGFR-2 and VEGFR-3 inhibitory anthranilamide pyridines
JP2008501628A (ja) * 2004-06-02 2008-01-24 武田薬品工業株式会社 インドール誘導体およびがんの治療用途
FR2917412B1 (fr) * 2007-06-13 2009-08-21 Sanofi Aventis Sa Derives de 7-alkynyl, 1,8-naphthyridones, leur preparation et leur application en therapeutique

Also Published As

Publication number Publication date
US8263614B2 (en) 2012-09-11
MA31674B1 (fr) 2010-09-01
EP2158194A2 (fr) 2010-03-03
BRPI0813809B1 (pt) 2021-05-25
ES2366629T3 (es) 2011-10-24
US20120238598A1 (en) 2012-09-20
IL202677A (en) 2014-12-31
HRP20110550T1 (hr) 2011-09-30
FR2917413A1 (fr) 2008-12-19
CA2690349A1 (fr) 2009-01-15
ATE509923T1 (de) 2011-06-15
NZ581883A (en) 2011-05-27
WO2009007536A3 (fr) 2009-03-19
PL2158194T3 (pl) 2011-10-31
FR2917413B1 (fr) 2009-08-21
CY1111748T1 (el) 2015-10-07
SI2158194T1 (sl) 2011-10-28
KR20100019507A (ko) 2010-02-18
EA016552B1 (ru) 2012-05-30
MX2009013514A (es) 2010-01-27
AR066955A1 (es) 2009-09-23
US8586602B2 (en) 2013-11-19
US20100144782A1 (en) 2010-06-10
AU2008274100A1 (en) 2009-01-15
HK1143590A1 (en) 2011-01-07
JP5346337B2 (ja) 2013-11-20
JP2010529179A (ja) 2010-08-26
IL202677A0 (en) 2010-06-30
WO2009007536A8 (fr) 2010-01-07
DK2158194T3 (da) 2011-09-12
AU2008274100B2 (en) 2013-07-11
CN101815715A (zh) 2010-08-25
MY146939A (en) 2012-10-15
PT2158194E (pt) 2011-08-17
WO2009007536A2 (fr) 2009-01-15
ME00957B (me) 2012-06-20
CA2690349C (fr) 2015-11-24
CO6150157A2 (es) 2010-04-20
EP2158194B1 (fr) 2011-05-18
IN2009KN04279A (ru) 2015-08-28
CN101815715B (zh) 2014-10-08
BRPI0813809A2 (pt) 2020-02-04

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