EA200501477A1 - Производные пиперидинил- и пиперазинилалкилкарбаматов, способы их получения и применение их в терапии - Google Patents

Производные пиперидинил- и пиперазинилалкилкарбаматов, способы их получения и применение их в терапии

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Publication number
EA200501477A1
EA200501477A1 EA200501477A EA200501477A EA200501477A1 EA 200501477 A1 EA200501477 A1 EA 200501477A1 EA 200501477 A EA200501477 A EA 200501477A EA 200501477 A EA200501477 A EA 200501477A EA 200501477 A1 EA200501477 A1 EA 200501477A1
Authority
EA
Eurasian Patent Office
Prior art keywords
therapy
piperasinilylkylkarbamats
piperidinyl
derivatives
production
Prior art date
Application number
EA200501477A
Other languages
English (en)
Other versions
EA009468B1 (ru
Inventor
Ахмед Абуабделла
Филипп Бюрнье
Кристиан Хорнар
Жан Женесс
Фредерик Пюэш
Original Assignee
Санофи-Авентис
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Publication date
Application filed by Санофи-Авентис filed Critical Санофи-Авентис
Publication of EA200501477A1 publication Critical patent/EA200501477A1/ru
Publication of EA009468B1 publication Critical patent/EA009468B1/ru

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    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Abstract

Изобретение относится к соединению, имеющему общую формулу (I), где A представляет собой N или CR; Rпредставляет собой H, F, OH, CN, CF, Cалкил, Cалкокси; n равно 2 или 3 и m равно 2, когда A представляет собой N; n равно 1, 2 или 3, и m равно 1 или 2, когда A представляет собой CR; B представляет собой ковалентную связь или Cалкилен; Rпредставляет собой возможно замещенный гетероарил; Rпредставляет собой CHRCONHR; Rпредставляет собой H или Cалкил; Rпредставляет собой H, Cалкил, Cциклоалкил, Cциклоалкил-Cалкилен; его основанию, полученной присоединением кислоты соли, гидрату или сольвату. Изобретение также относится к применению его в терапии.
EA200501477A 2003-05-07 2004-05-06 Производные пиперидинил- и пиперазинилалкилкарбаматов, способы их получения и применение их в терапии EA009468B1 (ru)

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FR0305540A FR2854633B1 (fr) 2003-05-07 2003-05-07 Derives de piperidinyl-et piperazinyl-alkylcarbamates, leur preparation et leur application en therapeutique
PCT/FR2004/001102 WO2004099176A1 (fr) 2003-05-07 2004-05-06 Derives de piperidinyl- et piperazinyl-alkylcarbamates, leurs procedes de preparation et leur application en therapeutique

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