EA201170222A1 - НОВЫЕ ПРОИЗВОДНЫЕ ТРИАЗОЛО[4,3-a]ПИРИДИНА, СПОСОБ ИХ ПОЛУЧЕНИЯ, ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ЛЕКАРСТВЕННЫХ СРЕДСТВ, ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ И НОВОЕ ПРИМЕНЕНИЕ, В ЧАСТНОСТИ, В КАЧЕСТВЕ ИНГИБИТОРОВ МЕТ - Google Patents

НОВЫЕ ПРОИЗВОДНЫЕ ТРИАЗОЛО[4,3-a]ПИРИДИНА, СПОСОБ ИХ ПОЛУЧЕНИЯ, ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ЛЕКАРСТВЕННЫХ СРЕДСТВ, ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ И НОВОЕ ПРИМЕНЕНИЕ, В ЧАСТНОСТИ, В КАЧЕСТВЕ ИНГИБИТОРОВ МЕТ

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Publication number
EA201170222A1
EA201170222A1 EA201170222A EA201170222A EA201170222A1 EA 201170222 A1 EA201170222 A1 EA 201170222A1 EA 201170222 A EA201170222 A EA 201170222A EA 201170222 A EA201170222 A EA 201170222A EA 201170222 A1 EA201170222 A1 EA 201170222A1
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EA
Eurasian Patent Office
Prior art keywords
application
new
inhibitors
pyridine
medicine
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EA201170222A
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English (en)
Inventor
Эрик Бак
Доминик Дамур
Консепсьон Немесек
Патрик Немесек
Сильви Венслер
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Санофи-Авентис
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41550767&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201170222(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from FR0804084A external-priority patent/FR2933980B1/fr
Priority claimed from FR0900245A external-priority patent/FR2941229B1/fr
Application filed by Санофи-Авентис filed Critical Санофи-Авентис
Publication of EA201170222A1 publication Critical patent/EA201170222A1/ru

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    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07D471/04—Ortho-condensed systems

Abstract

Изобретение относится к новым продуктам формулы (I), в которой Ra означает Н, Hal, арил или гетероарил, возможно замещенные; Rb означает Н, Re, -COORc, -CO-Rc или -CO-NRcRd; где Rc означает алкил, циклоалкил, гетероциклоалкил, арил и гетероарил, возможно все замещенные; Rd означает Н, alk или циклоалкил; причем эти продукты находятся в любых изомерных формах и в форме солей, в качестве лекарственных средств, в частности ингибиторов MET.
EA201170222A 2008-07-18 2009-07-16 НОВЫЕ ПРОИЗВОДНЫЕ ТРИАЗОЛО[4,3-a]ПИРИДИНА, СПОСОБ ИХ ПОЛУЧЕНИЯ, ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ЛЕКАРСТВЕННЫХ СРЕДСТВ, ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ И НОВОЕ ПРИМЕНЕНИЕ, В ЧАСТНОСТИ, В КАЧЕСТВЕ ИНГИБИТОРОВ МЕТ EA201170222A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0804084A FR2933980B1 (fr) 2008-07-18 2008-07-18 Nouveaux derives triazolo°4,3-a!pyridine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de met
FR0900245A FR2941229B1 (fr) 2009-01-21 2009-01-21 Nouveaux derives triazolo°4,3-a!pyridine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de met
PCT/FR2009/051406 WO2010007316A2 (fr) 2008-07-18 2009-07-16 NOUVEAUX DERIVES TRIAZOLO(4,3-a)PYRIDINE,LEUR PROCEDE DE PREPARATION,LEUR APPLICATION A TITRE DE MEDICAMENTS,COMPOSITIONS PHARMACEUTIQUES ET NOUVELLE UTILISATION NOTAMMENT COMME INHIBITEURS DE MET

Publications (1)

Publication Number Publication Date
EA201170222A1 true EA201170222A1 (ru) 2011-08-30

Family

ID=41550767

Family Applications (1)

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EA201170222A EA201170222A1 (ru) 2008-07-18 2009-07-16 НОВЫЕ ПРОИЗВОДНЫЕ ТРИАЗОЛО[4,3-a]ПИРИДИНА, СПОСОБ ИХ ПОЛУЧЕНИЯ, ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ЛЕКАРСТВЕННЫХ СРЕДСТВ, ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ И НОВОЕ ПРИМЕНЕНИЕ, В ЧАСТНОСТИ, В КАЧЕСТВЕ ИНГИБИТОРОВ МЕТ

Country Status (19)

Country Link
US (1) US20110263594A1 (ru)
EP (1) EP2310366A2 (ru)
JP (1) JP2011528337A (ru)
KR (1) KR20110039558A (ru)
CN (1) CN102159543A (ru)
AR (1) AR072819A1 (ru)
AU (1) AU2009272516A1 (ru)
BR (1) BRPI0916464A2 (ru)
CA (1) CA2730959A1 (ru)
CL (1) CL2011000119A1 (ru)
CO (1) CO6331463A2 (ru)
EA (1) EA201170222A1 (ru)
IL (1) IL210688A0 (ru)
MA (1) MA32570B1 (ru)
MX (1) MX2011000671A (ru)
PE (1) PE20110560A1 (ru)
TW (1) TW201008938A (ru)
UY (1) UY31996A (ru)
WO (1) WO2010007316A2 (ru)

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US20100041663A1 (en) 2008-07-18 2010-02-18 Novartis Ag Organic Compounds as Smo Inhibitors
US8759535B2 (en) 2010-02-18 2014-06-24 High Point Pharmaceuticals, Llc Substituted fused imidazole derivatives, pharmaceutical compositions, and methods of use thereof
FR2966151B1 (fr) * 2010-10-14 2012-11-09 Sanofi Aventis Derives de 6-(alkyl- ou cycloalkyl-triazolopyridazine-sulfanyl) benzothiazoles: preparation, application comme medicaments et utilisation comme inhibiteurs de met
EP2678016B1 (en) * 2011-02-23 2016-08-10 Intellikine, LLC Heterocyclic compounds and uses thereof
EP2755976B1 (en) 2011-09-15 2018-07-18 Novartis AG 6-substituted 3-(quinolin-6-ylthio)-[1,2,4]triazolo[4,3-a]pyridines as c-met tyrosine kinase inhibitors
AU2014262326B2 (en) * 2013-05-10 2018-03-22 Jiangsu Hansoh Pharmaceutical Co., Ltd. [1,2,4] triazol [4,3-a] pyridine derivate, preparation method therefor or medical application thereof
EP3004095A1 (de) * 2013-06-03 2016-04-13 Bayer Pharma Aktiengesellschaft Triazolopyridine als thrombininhibitoren zur behandlung von thromboembolischen erkrankungen
GB201321742D0 (en) * 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
WO2016089648A1 (en) 2014-12-01 2016-06-09 Vtv Therapeutics Llc Bach 1 inhibitors in combination with nrf2 activators and pharmaceutical compositions thereof
CN106489962B (zh) * 2016-10-20 2019-02-22 贵州大学 一种[1,2,4]***[4,3-a]吡啶类含硫化合物在制备杀虫剂中的应用
US11324729B2 (en) 2017-12-07 2022-05-10 The Regents Of The University Of Michigan NSD family inhibitors and methods of treatment therewith
AU2020242287A1 (en) 2019-03-21 2021-09-02 INSERM (Institut National de la Santé et de la Recherche Médicale) A Dbait molecule in combination with kinase inhibitor for the treatment of cancer
WO2021089791A1 (en) 2019-11-08 2021-05-14 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use

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US2857371A (en) * 1954-09-10 1958-10-21 Eastman Kodak Co Benzothiazole azo diphenylamine compounds
JPS5775976A (en) * 1980-08-27 1982-05-12 Glaxo Group Ltd Novel heterocyclic derivative, manufacture and medicinal composition containing same
FR2601952B1 (fr) * 1986-07-23 1988-11-25 Carpibem Nouveaux derives amino alkyl thio de triazolopyridine ou triazoloquinoline, leurs procedes de preparation, medicaments les contenant, utiles notamment comme antalgiques
US7008748B1 (en) * 2004-09-07 2006-03-07 Eastman Kodak Company Silver salt-toner co-precipitates and imaging materials
ME02736B (me) * 2005-12-21 2017-10-20 Janssen Pharmaceutica Nv Triazolopiridazini kao modulatori tirozin kinaze
WO2008092891A1 (en) * 2007-02-01 2008-08-07 Glaxo Group Limited 1-oxa-3-azaspiro(4.5)decan-2-one derivatives for the treatment of eating disorders
PA8792501A1 (es) * 2007-08-09 2009-04-23 Sanofi Aventis Nuevos derivados de 6-triazolopiridacina-sulfanil benzotiazol y bencimidazol,su procedimiento de preparación,su aplicación como medicamentos,composiciones farmacéuticas y nueva utilización principalmente como inhibidores de met.

Also Published As

Publication number Publication date
AR072819A1 (es) 2010-09-22
WO2010007316A3 (fr) 2010-04-29
UY31996A (es) 2010-02-26
CA2730959A1 (fr) 2010-01-21
AU2009272516A1 (en) 2010-01-21
KR20110039558A (ko) 2011-04-19
BRPI0916464A2 (pt) 2018-06-12
US20110263594A1 (en) 2011-10-27
EP2310366A2 (fr) 2011-04-20
MA32570B1 (fr) 2011-08-01
TW201008938A (en) 2010-03-01
PE20110560A1 (es) 2011-08-29
MX2011000671A (es) 2011-04-11
WO2010007316A2 (fr) 2010-01-21
CL2011000119A1 (es) 2011-06-17
IL210688A0 (en) 2011-03-31
CN102159543A (zh) 2011-08-17
CO6331463A2 (es) 2011-10-20
JP2011528337A (ja) 2011-11-17

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