CY1114704T1 - Κρυσταλλικη μορφη δ του αλατος αργινινης της περινδοπριλης, μεθοδος παρασκευης της και φαρμακευτικες συνθεσεις οι οποιες την περιεχουν - Google Patents

Κρυσταλλικη μορφη δ του αλατος αργινινης της περινδοπριλης, μεθοδος παρασκευης της και φαρμακευτικες συνθεσεις οι οποιες την περιεχουν

Info

Publication number
CY1114704T1
CY1114704T1 CY20131101094T CY131101094T CY1114704T1 CY 1114704 T1 CY1114704 T1 CY 1114704T1 CY 20131101094 T CY20131101094 T CY 20131101094T CY 131101094 T CY131101094 T CY 131101094T CY 1114704 T1 CY1114704 T1 CY 1114704T1
Authority
CY
Cyprus
Prior art keywords
crystalline form
preparation
pharmaceutical compositions
arginine salt
perindopril arginine
Prior art date
Application number
CY20131101094T
Other languages
English (en)
Inventor
Julie Linol
Stéphane Laurent
Arnaud Grenier
Sébastien Mathieu
Original Assignee
Les Laboratoires Servier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47427277&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1114704(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Les Laboratoires Servier filed Critical Les Laboratoires Servier
Publication of CY1114704T1 publication Critical patent/CY1114704T1/el

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B43/00—Forming, feeding, opening or setting-up containers or receptacles in association with packaging
    • B65B43/42—Feeding or positioning bags, boxes, or cartons in the distended, opened, or set-up state; Feeding preformed rigid containers, e.g. tins, capsules, glass tubes, glasses, to the packaging position; Locating containers or receptacles at the filling position; Supporting containers or receptacles during the filling operation
    • B65B43/46—Feeding or positioning bags, boxes, or cartons in the distended, opened, or set-up state; Feeding preformed rigid containers, e.g. tins, capsules, glass tubes, glasses, to the packaging position; Locating containers or receptacles at the filling position; Supporting containers or receptacles during the filling operation using grippers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
    • A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65G—TRANSPORT OR STORAGE DEVICES, e.g. CONVEYORS FOR LOADING OR TIPPING, SHOP CONVEYOR SYSTEMS OR PNEUMATIC TUBE CONVEYORS
    • B65G47/00—Article or material-handling devices associated with conveyors; Methods employing such devices
    • B65G47/74—Feeding, transfer, or discharging devices of particular kinds or types
    • B65G47/90—Devices for picking-up and depositing articles or materials
    • B65G47/91—Devices for picking-up and depositing articles or materials incorporating pneumatic, e.g. suction, grippers
    • B65G47/912—Devices for picking-up and depositing articles or materials incorporating pneumatic, e.g. suction, grippers provided with drive systems with rectilinear movements only
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C277/08—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups of substituted guanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65G—TRANSPORT OR STORAGE DEVICES, e.g. CONVEYORS FOR LOADING OR TIPPING, SHOP CONVEYOR SYSTEMS OR PNEUMATIC TUBE CONVEYORS
    • B65G2201/00—Indexing codes relating to handling devices, e.g. conveyors, characterised by the type of product or load being conveyed or handled
    • B65G2201/02—Articles
    • B65G2201/0235—Containers

Abstract

Κρυσταλλική μορφή δ της ένωσης του τύπου (Ι): η οποία χαρακτηρίζεται από το διάγραμμα της περίθλασης Χ επί σκόνης. Φάρμακα.
CY20131101094T 2012-01-05 2013-12-04 Κρυσταλλικη μορφη δ του αλατος αργινινης της περινδοπριλης, μεθοδος παρασκευης της και φαρμακευτικες συνθεσεις οι οποιες την περιεχουν CY1114704T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR1200033A FR2985511B1 (fr) 2012-01-05 2012-01-05 Forme cristalline delta du sel d'arginine du perindopril, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
EP13150296.5A EP2612850B1 (fr) 2012-01-05 2013-01-04 Forme cristalline delta du sel d'arginine du périndopril, son procédé de préparation, et les compositions pharmaceutiques qui la contiennent

Publications (1)

Publication Number Publication Date
CY1114704T1 true CY1114704T1 (el) 2016-10-05

Family

ID=47427277

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20131101094T CY1114704T1 (el) 2012-01-05 2013-12-04 Κρυσταλλικη μορφη δ του αλατος αργινινης της περινδοπριλης, μεθοδος παρασκευης της και φαρμακευτικες συνθεσεις οι οποιες την περιεχουν

Country Status (44)

Country Link
US (1) US8835652B2 (el)
EP (1) EP2612850B1 (el)
JP (1) JP5722923B2 (el)
KR (1) KR101502945B1 (el)
CN (1) CN103193864B (el)
AP (1) AP2013006657A0 (el)
AR (1) AR089631A1 (el)
AU (1) AU2012268815B2 (el)
BR (1) BR102013000161B1 (el)
CA (1) CA2800946C (el)
CL (1) CL2013000021A1 (el)
CO (1) CO6700139A1 (el)
CR (1) CR20120655A (el)
CU (1) CU20130001A7 (el)
CY (1) CY1114704T1 (el)
DK (1) DK2612850T3 (el)
EA (1) EA022574B1 (el)
EC (1) ECSP13012365A (el)
ES (1) ES2439871T3 (el)
FR (1) FR2985511B1 (el)
GE (1) GEP20146182B (el)
GT (1) GT201300003A (el)
HK (1) HK1187061A1 (el)
HR (1) HRP20131164T1 (el)
IL (1) IL223752A (el)
JO (1) JO3084B1 (el)
MA (1) MA35002B1 (el)
MD (1) MD4350C1 (el)
MX (1) MX2013000013A (el)
MY (1) MY176877A (el)
NI (1) NI201200194A (el)
PE (1) PE20131327A1 (el)
PH (1) PH12012000393B1 (el)
PL (1) PL2612850T3 (el)
PT (1) PT2612850E (el)
RS (1) RS53001B (el)
SA (1) SA113340173B1 (el)
SG (1) SG192336A1 (el)
SI (1) SI2612850T1 (el)
TN (1) TN2012000619A1 (el)
TW (1) TWI471307B (el)
UA (1) UA111334C2 (el)
UY (1) UY34552A (el)
WO (1) WO2013102741A1 (el)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3050380B1 (fr) 2016-04-20 2020-07-10 Les Laboratoires Servier Composition pharmaceutique comprenant un betabloquant, un inhibiteur de l'enzyme de conversion et un antihypertenseur ou un ains.
CN110283104B (zh) * 2018-08-22 2022-06-14 南京济群医药科技股份有限公司 一种精氨酸培哚普利的制备方法
EP3842035A1 (en) 2019-12-23 2021-06-30 KRKA, d.d., Novo mesto Composition for the preparation of perindopril arginine granules, a method for their preparation and pharmaceutical composition comprising the granules
SI26268A (sl) 2021-11-18 2023-05-31 Zupet Rok Postopek za pripravo hidratirane oblike perindopril l-arginina
CN114149357A (zh) * 2021-12-29 2022-03-08 江苏嘉逸医药有限公司 一种γ晶型培哚普利精氨酸盐的制备方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2503155A2 (fr) * 1980-10-02 1982-10-08 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
FR2620703B1 (fr) * 1987-09-17 1991-10-04 Adir Procede de synthese industrielle de l'acide perhydroindole carboxylique - 2(2s, 3as, 7as). application a la synthese de carboxyalkyl dipeptides
JPH04352788A (ja) * 1990-08-30 1992-12-07 Kanebo Ltd 新規キノリンカルボン酸誘導体、該化合物を有効成分とする抗菌剤および該化合物の製造方法
EP0934941A1 (en) * 1996-08-09 1999-08-11 Eisai Co., Ltd. Benzopiperidine derivatives
FR2838648B1 (fr) * 2002-04-18 2004-05-21 Servier Lab Nouveau sel de perindopril et les compositions pharmaceutiques qui le contiennent
JP4402361B2 (ja) * 2003-03-31 2010-01-20 大日本印刷株式会社 塩酸エピナスチンの結晶多形
AU2006281681A1 (en) * 2005-08-12 2007-02-22 Sandoz Ag New crystalline form of perindopril erbumine
FR2897866B1 (fr) * 2006-02-28 2008-04-18 Servier Lab Forme cristalline alpha du sel d'arginine du perindopril, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
FR2897865B1 (fr) * 2006-02-28 2008-04-18 Servier Lab Forme cristalline beta du sel d'arginine du perindopril, son procede de preparation, et les compositions pharmaceutiques qui la contiennent
EP1864973A1 (en) * 2006-06-09 2007-12-12 Sochinaz SA Process for the preparation of perindopril and salts thereof
JP5576854B2 (ja) * 2008-04-01 2014-08-20 ルマヴィータ・アクチェンゲゼルシャフト 高純度ペンタマイシン
EP2682388B1 (en) * 2008-06-24 2018-01-10 Mylan Laboratories Limited Novel polymorphic forms of perindopril (l)-arginine and process for the preparation thereof
AU2009212902A1 (en) * 2008-09-03 2010-03-18 Apotex Pharmachem Inc. Amorphous form of an L-arginine salt of perindopril and processes of preparation thereof
SI23001A (sl) * 2009-03-20 2010-09-30 Diagen@d@o@o Nove soli perindoprila nov postopek za njihovo pripravo in njihova uporaba za zdravljenje kardiovaskularnih bolezni
CN102114017A (zh) * 2011-01-05 2011-07-06 王定豪 包含氨氯地平和培哚普利的药物组合物及其应用

Also Published As

Publication number Publication date
MX2013000013A (es) 2013-07-15
HRP20131164T1 (hr) 2014-01-03
TW201331178A (zh) 2013-08-01
SI2612850T1 (sl) 2014-01-31
PE20131327A1 (es) 2013-11-15
HK1187061A1 (en) 2014-03-28
CA2800946A1 (fr) 2013-07-05
AU2012268815B2 (en) 2014-02-13
CN103193864B (zh) 2014-09-17
AU2012268815A1 (en) 2013-07-18
KR20130080814A (ko) 2013-07-15
AR089631A1 (es) 2014-09-03
BR102013000161A2 (pt) 2015-05-12
TWI471307B (zh) 2015-02-01
PH12012000393A1 (en) 2014-07-28
PT2612850E (pt) 2013-11-21
IL223752A (en) 2016-08-31
PH12012000393B1 (en) 2014-07-28
CA2800946C (fr) 2014-07-15
JP5722923B2 (ja) 2015-05-27
FR2985511B1 (fr) 2014-01-03
CO6700139A1 (es) 2013-06-28
MD4350B1 (ro) 2015-05-31
CU20130001A7 (es) 2014-08-28
EA022574B1 (ru) 2016-01-29
EP2612850A1 (fr) 2013-07-10
JO3084B1 (ar) 2017-03-15
PL2612850T3 (pl) 2014-01-31
NZ605264A (en) 2013-12-20
SA113340173B1 (ar) 2015-07-09
CN103193864A (zh) 2013-07-10
KR101502945B1 (ko) 2015-03-16
ECSP13012365A (es) 2013-04-30
EP2612850B1 (fr) 2013-09-18
JP2013139444A (ja) 2013-07-18
TN2012000619A1 (fr) 2014-04-01
UY34552A (es) 2013-07-31
UA111334C2 (uk) 2016-04-25
WO2013102741A1 (fr) 2013-07-11
EA201201668A1 (ru) 2013-10-30
CR20120655A (es) 2013-03-05
US8835652B2 (en) 2014-09-16
CL2013000021A1 (es) 2014-07-18
FR2985511A1 (fr) 2013-07-12
AP2013006657A0 (en) 2013-01-31
GT201300003A (es) 2014-03-14
BR102013000161B1 (pt) 2021-11-09
US20130178464A1 (en) 2013-07-11
NI201200194A (es) 2013-05-13
SG192336A1 (en) 2013-08-30
MA35002B1 (fr) 2014-04-03
RS53001B (en) 2014-04-30
MY176877A (en) 2020-08-25
GEP20146182B (en) 2014-10-27
IL223752A0 (en) 2013-07-31
MD4350C1 (ro) 2015-12-31
MD20120130A2 (en) 2013-07-31
DK2612850T3 (da) 2013-12-16
ES2439871T3 (es) 2014-01-27

Similar Documents

Publication Publication Date Title
CY1125155T1 (el) Κρυσταλλικες μορφες αναστολεα προλυλο υδροξυλασης
CY1120480T1 (el) Ενωσεις πυραζολοπυριμιδινης
EA201401292A2 (ru) Новые тиенопиримидиновые производные, способ их получения и фармацевтические композиции, содержащие их
CY1118196T1 (el) Νεα κρυσταλλικη μορφη vi της αγομελατινης, μεθοδος παρασκευης αυτης και οι φαρμακευτικες συνθεσεις που την περιεχουν
CY1123670T1 (el) Κρυσταλλικο παραγωγο 6,7-ακορεστης-7-καρβαμοϋλ μορφινανης, και μεθοδος για την παραγωγη αυτου
EA201890124A1 (ru) Новые гидроксикислотные производные, способ их получения и фармацевтические композиции, содержащие их
EA201890123A1 (ru) Новые аминокислотные производные, способ их получения и фармацевтические композиции, содержащие их
EA201590879A1 (ru) Арилконденсированные и гетероарилконденсированные лактамы
EA201400753A1 (ru) Новые пиррольные соединения, способ их получения и фармацевтические композиции, содержащие их
EA201390908A1 (ru) Производные бицикло[3.2.1]октиламида и их применение
CY1117753T1 (el) Κρυσταλλικη μορφη του αλατος αργινινης της περινδοπριλης, μεθοδος παρασκευης της και φαρμακευτικες συνθεσεις οι οποιες την περιεχουν
EA201270741A1 (ru) Пероральные композиции и липофильные соли метилналтрексона
EA201492287A1 (ru) Дейтерированные производные руксолитиниба
EA201600337A1 (ru) 2,6-замещенные пуриновые производные и их применение в лечении пролиферативных заболеваний
AU2014224456A8 (en) Novel abexinostate salt, associated crystalline form, preparation method thereof and the pharmaceutical compositions containing same
CY1118514T1 (el) Μεθοδος για την παρασκευη πεμετρεξιδης και αλατος λυσινης αυτης
CY1114704T1 (el) Κρυσταλλικη μορφη δ του αλατος αργινινης της περινδοπριλης, μεθοδος παρασκευης της και φαρμακευτικες συνθεσεις οι οποιες την περιεχουν
CY1118079T1 (el) Μεθοδος παρασκευης του αλατος l-αργινινικης περινδοπριλης
EA201200616A1 (ru) Производные 2-оксо-1-пирролидинилимидазотиадиазола
CY1117912T1 (el) Ενωσεις πυραζολιου ως αναστολεiς του συμμεταφορεα νατριου-γλυκοζης 1 (sglt1)
CY1117210T1 (el) Παραγωγα 2-οξο-1-ιμιδαζολιδινυλ ιμιδαζοθειαδιαζολης
EA201590250A1 (ru) Производные карбамат/мочевины
UA118562C2 (uk) Модулятори рецептора cxcr7
CY1124838T1 (el) Αλας παραγωγου κεφαλοσπορινης, κρυσταλλικη, στερεη μορφη αυτου και μεθοδος παραγωγης αυτου
EA201600394A1 (ru) Трициклические соединения пиперидина