EA200970364A1 - Новые производные имидазолонов в качестве лекарственных средств, способ их получения, фармацевтические композиции и применение в качестве ингибиторов протеинкиназ, в частности, cdc7 - Google Patents
Новые производные имидазолонов в качестве лекарственных средств, способ их получения, фармацевтические композиции и применение в качестве ингибиторов протеинкиназ, в частности, cdc7Info
- Publication number
- EA200970364A1 EA200970364A1 EA200970364A EA200970364A EA200970364A1 EA 200970364 A1 EA200970364 A1 EA 200970364A1 EA 200970364 A EA200970364 A EA 200970364A EA 200970364 A EA200970364 A EA 200970364A EA 200970364 A1 EA200970364 A1 EA 200970364A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- alkyl
- cdc7
- inhibitors
- protectininase
- imidazolones
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
Abstract
Изобретение относится в продуктам формулы (I), в которой X-Y обозначает NH-C(S), N=C-NR7R8, N=C-SR, N=C-R или N=C-OR; R и R1 обозначает Н, циклоалкил, алкил, гетероциклоалкил, арил или гетероарил, необязательно замещенные; R2 обозначает Н, галоген или радикал алкил; R3 обозначает Н, галоген, ОН, алкил или алкокси; R4 обозначает Н, галоген, циано, CF3 или алкил; R5 обозначает, в частности, Н, галоген, ОН, NR7R8, циклоалкил, алкил, алкокси, гетероциклоалкил, арил или гетероарил, необязательно замещенные; R6 обозначает Н, галоген, ОН, NH алк, N(алк)2, алкил или алкокси; где R7 и R8 такие, что один обозначает Н или алк, необязательно замещенный; а другой обозначает Н, циклоалкил, алкил, гетероциклоалкил, гетероарил или арил, необязательно замещенные; или же R7 и R8 вместе с N образуют циклический радикал, необязательно содержащий О, S или N, необязательно замещенный; к их изомерам и их солям, к их применению в качестве лекарственных средств, в частности в качестве ингибиторов киназ, более конкретно CDC7.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0608924A FR2907120B1 (fr) | 2006-10-12 | 2006-10-12 | Nouveaux derives imidazolones,leur preparation a titre de medicaments,compositions pharmaceutiques,utilisation comme inhibiteurs de proteines kinases notamment cdc7 |
| PCT/FR2007/001651 WO2008046982A2 (fr) | 2006-10-12 | 2007-10-10 | Nouveaux derives imidazolones, leur preparation a titre de medicaments, compositions pharmaceutiques, utilisation comme inhibiteurs de proteines kinases notamment cdc7 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200970364A1 true EA200970364A1 (ru) | 2009-10-30 |
| EA018496B1 EA018496B1 (ru) | 2013-08-30 |
Family
ID=37964098
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200970364A EA018496B1 (ru) | 2006-10-12 | 2007-10-10 | Новые производные имидазолонов в качестве лекарственных средств, способ их получения, фармацевтические композиции и применение в качестве ингибиторов протеинкиназ, в частности cdc7 |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US8314121B2 (ru) |
| EP (1) | EP2094699B1 (ru) |
| JP (1) | JP2010505922A (ru) |
| KR (1) | KR101552361B1 (ru) |
| CN (1) | CN101522678A (ru) |
| AR (1) | AR063249A1 (ru) |
| AT (1) | ATE517105T1 (ru) |
| AU (1) | AU2007311833B2 (ru) |
| BR (1) | BRPI0719790A2 (ru) |
| CA (1) | CA2660166C (ru) |
| CL (1) | CL2007002934A1 (ru) |
| CO (1) | CO6160310A2 (ru) |
| CY (1) | CY1112066T1 (ru) |
| DK (1) | DK2094699T3 (ru) |
| EA (1) | EA018496B1 (ru) |
| ES (1) | ES2370049T3 (ru) |
| FR (1) | FR2907120B1 (ru) |
| HR (1) | HRP20110759T1 (ru) |
| IL (1) | IL197452A (ru) |
| MA (1) | MA30877B1 (ru) |
| MX (1) | MX2009003283A (ru) |
| NO (1) | NO20091486L (ru) |
| PL (1) | PL2094699T3 (ru) |
| PT (1) | PT2094699E (ru) |
| RS (1) | RS51985B (ru) |
| SI (1) | SI2094699T1 (ru) |
| TW (1) | TW200821310A (ru) |
| UY (1) | UY30642A1 (ru) |
| WO (1) | WO2008046982A2 (ru) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2423204A4 (en) | 2009-04-20 | 2013-01-09 | Sbi Biotech Co Ltd | THIAZOLIDINONDERIVAT |
| WO2011008915A1 (en) * | 2009-07-15 | 2011-01-20 | Abbott Laboratories | Pyrrolopyridine inhibitors of kinases |
| CA2782684C (en) * | 2009-12-04 | 2018-09-04 | Mustapha Haddach | Pyrazolopyrimidines and related heterocycles as ck2 inhibitors |
| EP2560971B1 (en) * | 2010-04-19 | 2014-04-09 | Abbvie Inc. | Pyrrolopyridines as inhibitors of kinases |
| USRE48140E1 (en) * | 2011-03-31 | 2020-08-04 | Carna Biosciences, Inc. | Furanone derivative |
| JP6569908B2 (ja) | 2014-01-31 | 2019-09-04 | カルナバイオサイエンス株式会社 | 抗がん剤組成物 |
| GB201807147D0 (en) | 2018-05-01 | 2018-06-13 | Oncologica Uk Ltd | Therapeutic combination |
| CN114945569A (zh) * | 2019-12-26 | 2022-08-26 | 延世大学校产学协力团 | 吡咯烷衍生物，以及包含其的用于预防或治疗β-淀粉样蛋白或Tau蛋白相关疾病的药物组合物 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6335342B1 (en) | 2000-06-19 | 2002-01-01 | Pharmacia & Upjohn S.P.A. | Azaindole derivatives, process for their preparation, and their use as antitumor agents |
| JP4787150B2 (ja) | 2003-03-06 | 2011-10-05 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | Ｊｎｋ阻害剤 |
| BRPI0413438A (pt) * | 2003-08-08 | 2006-10-17 | Pharmacia Italia Spa | derivados de pirimidilpirrol ativos como inibidores de cinase |
| CA2561724A1 (en) | 2004-04-02 | 2005-11-03 | Vertex Pharmaceuticals Incorporated | Azaindoles useful as inhibitors of rock and other protein kinases |
| ES2301066T3 (es) * | 2004-10-14 | 2008-06-16 | F. Hoffmann-La Roche Ag | Nuevas azaindol-tiazolinonas como agentes anti-cancerosos. |
| US7371862B2 (en) * | 2005-11-11 | 2008-05-13 | Pfizer Italia S.R.L. | Azaindolylidene derivatives as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them |
-
2006
- 2006-10-12 FR FR0608924A patent/FR2907120B1/fr not_active Expired - Fee Related
-
2007
- 2007-10-10 EP EP07858418A patent/EP2094699B1/fr active Active
- 2007-10-10 PT PT07858418T patent/PT2094699E/pt unknown
- 2007-10-10 EA EA200970364A patent/EA018496B1/ru not_active IP Right Cessation
- 2007-10-10 CN CNA2007800378600A patent/CN101522678A/zh active Pending
- 2007-10-10 MX MX2009003283A patent/MX2009003283A/es active IP Right Grant
- 2007-10-10 BR BRPI0719790-0A2A patent/BRPI0719790A2/pt not_active IP Right Cessation
- 2007-10-10 RS RS20110456A patent/RS51985B/en unknown
- 2007-10-10 DK DK07858418.2T patent/DK2094699T3/da active
- 2007-10-10 PL PL07858418T patent/PL2094699T3/pl unknown
- 2007-10-10 ES ES07858418T patent/ES2370049T3/es active Active
- 2007-10-10 AU AU2007311833A patent/AU2007311833B2/en not_active Ceased
- 2007-10-10 SI SI200730750T patent/SI2094699T1/sl unknown
- 2007-10-10 JP JP2009531874A patent/JP2010505922A/ja not_active Revoked
- 2007-10-10 AT AT07858418T patent/ATE517105T1/de active
- 2007-10-10 CA CA2660166A patent/CA2660166C/fr not_active Expired - Fee Related
- 2007-10-10 KR KR1020097007392A patent/KR101552361B1/ko not_active IP Right Cessation
- 2007-10-10 WO PCT/FR2007/001651 patent/WO2008046982A2/fr active Application Filing
- 2007-10-11 CL CL200702934A patent/CL2007002934A1/es unknown
- 2007-10-11 AR ARP070104500A patent/AR063249A1/es unknown
- 2007-10-12 UY UY30642A patent/UY30642A1/es not_active Application Discontinuation
- 2007-10-12 TW TW096138357A patent/TW200821310A/zh unknown
-
2009
- 2009-03-05 IL IL197452A patent/IL197452A/en not_active IP Right Cessation
- 2009-03-31 US US12/415,391 patent/US8314121B2/en not_active Expired - Fee Related
- 2009-04-08 CO CO09036259A patent/CO6160310A2/es unknown
- 2009-04-16 NO NO20091486A patent/NO20091486L/no not_active Application Discontinuation
- 2009-05-08 MA MA31856A patent/MA30877B1/fr unknown
-
2011
- 2011-10-19 HR HR20110759T patent/HRP20110759T1/hr unknown
- 2011-10-20 CY CY20111100996T patent/CY1112066T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EA200970364A1 (ru) | Новые производные имидазолонов в качестве лекарственных средств, способ их получения, фармацевтические композиции и применение в качестве ингибиторов протеинкиназ, в частности, cdc7 | |
| EA200870192A1 (ru) | Новые серосодержащие производные циклической мочевины, их получение и их фармацевтическое применение в качестве ингибиторов киназ | |
| EA201001682A1 (ru) | Производные фенил- и бензодиоксинилзамещенных индазолов | |
| CY1118973T1 (el) | Παραγωγα αμιδιου βενζοϊμιδαζολο-καρβοξυλικου οξεος για τη θεραπεια μεταβολικων ή καρδιαγγειακων νοσηματων | |
| EA200700168A1 (ru) | Производные замещенной циклической мочевины, их получение и их фармацевтическое применение в качестве ингибиторов киназы | |
| CY1113269T1 (el) | Παραγωγα ινδαζολυλ αμιδιου για τη θεραπευτικη αγωγη διαταραχων διαμεσολαβουμενων υπο υποδοχεα γλυκοκορτικοειδων | |
| CY1114906T1 (el) | Νεα παραγωγα 6-τριαζολοπυριδαζινο-σουλφανυλο βενζοθειαζολης και βενζιμιδαζολης, η διαδικασια της παρασκευης τους, η εφαρμογη τους ως φαρμακα, φαρμακευτικες συνθεσεις και νεα χρηση κυριως ως αναστολεις του μετ | |
| EA200970156A1 (ru) | Пиридизиноновые производные | |
| EA201890086A1 (ru) | 1,4-замещенные производные пиперидина | |
| EA201101341A1 (ru) | Соединения, ингибирующие киназы, и фармацевтическая композиция на их основе | |
| EA200700142A1 (ru) | Замещенные гетероциклом циклические производные мочевины, их получение и их фармацевтическое применение в качестве ингибиторов киназы | |
| NO20073791L (no) | Pyrazolylaminopyridinderivater anvendbare som kinaseinhibitorer | |
| EA201170772A1 (ru) | Органические соединения | |
| EA201591703A1 (ru) | Замещенные 2-азабициклы и их применение в качестве модуляторов рецепторов орексина | |
| EA201291356A1 (ru) | Пиперидиноновые производные как ингибиторы mdm2 для лечения рака | |
| NO20082975L (no) | Nye cykliske ureaderivater, fremstilling derav og farmasoytisk anvendelse derav som kinaseinhibitorer | |
| EA201101566A1 (ru) | Производные имидазола и их применение в качестве модуляторов циклинзависимых киназ | |
| EA201170222A1 (ru) | НОВЫЕ ПРОИЗВОДНЫЕ ТРИАЗОЛО[4,3-a]ПИРИДИНА, СПОСОБ ИХ ПОЛУЧЕНИЯ, ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ЛЕКАРСТВЕННЫХ СРЕДСТВ, ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ И НОВОЕ ПРИМЕНЕНИЕ, В ЧАСТНОСТИ, В КАЧЕСТВЕ ИНГИБИТОРОВ МЕТ | |
| CY1124528T1 (el) | Ν-υποκατεστημενα παραγωγα ινδολης | |
| EA200601065A1 (ru) | Производные имидазола, способы их получения и применения | |
| EA201170224A1 (ru) | Новые производные имидазо[1,2-a]пиримидинов, способ их получения, их применение в качестве лекарственных средств, фармацевтические композиции и новое применение, в частности, в качестве ингибиторов мет | |
| EA201071269A1 (ru) | 3,4-замещенные пиперидиновые производные в качестве ингибиторов ренина | |
| EA201001087A1 (ru) | Новые дигидроиндолоновые соединения, способ их получения и фармацевтические композиции, содержащие их | |
| EA201000340A1 (ru) | Аминобензилзамещенные циклические сульфоны, полезные в качестве ингибиторов васе | |
| PH12014501181A1 (en) | N- (4 -quinolinylmethyl) sulfonamide derivatives and their use as anthelmintics |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM |
|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): RU |