EA201100638A1 - Тригидрохлориды производного дигидроптеридинона и способы их получения - Google Patents

Тригидрохлориды производного дигидроптеридинона и способы их получения

Info

Publication number
EA201100638A1
EA201100638A1 EA201100638A EA201100638A EA201100638A1 EA 201100638 A1 EA201100638 A1 EA 201100638A1 EA 201100638 A EA201100638 A EA 201100638A EA 201100638 A EA201100638 A EA 201100638A EA 201100638 A1 EA201100638 A1 EA 201100638A1
Authority
EA
Eurasian Patent Office
Prior art keywords
derivative
trihydrochlorides
dihydropteridinone
recovery
methods
Prior art date
Application number
EA201100638A
Other languages
English (en)
Other versions
EA018663B1 (ru
Inventor
Маттиас Грауерт
Гюнтер Линц
Рольф Шмид
Петер Зигер
Original Assignee
Бёрингер Ингельхайм Интернациональ Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Бёрингер Ингельхайм Интернациональ Гмбх filed Critical Бёрингер Ингельхайм Интернациональ Гмбх
Publication of EA201100638A1 publication Critical patent/EA201100638A1/ru
Publication of EA018663B1 publication Critical patent/EA018663B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • AIDS & HIV (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

В заявке описана специфическая соль производного дигидроптеридинона, а именно, тригидрохлорид соединения N-[транс-4-[4-(циклопропилметил)-1-пиперазинил]циклогексил]-4-[[(7R)-7-этил-5,6,7,8-тетрагидро-5-метил-8-(1-метилэтил)-6-оксо-2-птеридинил]амино]-3-метоксибензамида, его кристаллизация в форме гидрата, способ ее получения и ее применение в фармацевтической композиции.
EA201100638A 2006-02-08 2007-02-07 Способ получения производного дигидроптеридинона EA018663B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06101414 2006-02-08

Publications (2)

Publication Number Publication Date
EA201100638A1 true EA201100638A1 (ru) 2011-10-31
EA018663B1 EA018663B1 (ru) 2013-09-30

Family

ID=38008126

Family Applications (2)

Application Number Title Priority Date Filing Date
EA200801769A EA015389B1 (ru) 2006-02-08 2007-02-07 Тригидрохлорид производного дигидроптеридинона и способ его получения
EA201100638A EA018663B1 (ru) 2006-02-08 2007-02-07 Способ получения производного дигидроптеридинона

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EA200801769A EA015389B1 (ru) 2006-02-08 2007-02-07 Тригидрохлорид производного дигидроптеридинона и способ его получения

Country Status (22)

Country Link
US (3) US7439358B2 (ru)
EP (2) EP2543669A3 (ru)
JP (1) JP5134552B2 (ru)
KR (2) KR101445114B1 (ru)
CN (2) CN102093360B (ru)
AR (1) AR059349A1 (ru)
AU (1) AU2007213752B2 (ru)
BR (1) BRPI0707604A8 (ru)
CA (1) CA2635834C (ru)
EA (2) EA015389B1 (ru)
EC (1) ECSP088589A (ru)
HK (2) HK1127772A1 (ru)
IL (2) IL193217A (ru)
NO (1) NO20082610L (ru)
NZ (2) NZ570987A (ru)
PE (2) PE20110100A1 (ru)
SG (2) SG169397A1 (ru)
TW (1) TW200738716A (ru)
UA (2) UA101060C2 (ru)
UY (1) UY30136A1 (ru)
WO (1) WO2007090844A1 (ru)
ZA (1) ZA200804587B (ru)

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IL193217A (en) 2017-06-29
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UA95625C2 (ru) 2011-08-25
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EP2543669A2 (en) 2013-01-09
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WO2007090844A1 (en) 2007-08-16
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AR059349A1 (es) 2008-03-26
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IL236736A0 (en) 2015-02-26
UY30136A1 (es) 2007-09-28
AU2007213752B2 (en) 2013-01-17
CN102093360B (zh) 2014-11-05
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