MX2009008084A - Derivados de 5,6,7,8-tetrahidropteridina como inhibidores de hsp90. - Google Patents
Derivados de 5,6,7,8-tetrahidropteridina como inhibidores de hsp90.Info
- Publication number
- MX2009008084A MX2009008084A MX2009008084A MX2009008084A MX2009008084A MX 2009008084 A MX2009008084 A MX 2009008084A MX 2009008084 A MX2009008084 A MX 2009008084A MX 2009008084 A MX2009008084 A MX 2009008084A MX 2009008084 A MX2009008084 A MX 2009008084A
- Authority
- MX
- Mexico
- Prior art keywords
- hsp90 inhibitors
- medicaments
- treatment
- tetrahydropteridine
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Abstract
La presente invención se refiere a compuestos que inhiben la función de HSP90, procesos para su preparación, composiciones farmacéuticas que los contienen como el ingrediente activo, a su uso como medicamentos y a su uso en la fabricación de medicamentos para uso en el tratamiento en animales de sangre calientes tal como humanos de enfermedades tal como para el tratamiento de tumores sólidos.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US88771607P | 2007-02-01 | 2007-02-01 | |
US95065407P | 2007-07-19 | 2007-07-19 | |
PCT/GB2008/000303 WO2008093075A2 (en) | 2007-02-01 | 2008-01-31 | 5,6,7,8-tetrahydropteridine derivatives as hsp90 inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009008084A true MX2009008084A (es) | 2009-10-12 |
Family
ID=39365852
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009008084A MX2009008084A (es) | 2007-02-01 | 2008-01-31 | Derivados de 5,6,7,8-tetrahidropteridina como inhibidores de hsp90. |
Country Status (13)
Country | Link |
---|---|
US (1) | US7799781B2 (es) |
EP (1) | EP2109612B1 (es) |
JP (1) | JP2010517989A (es) |
KR (1) | KR20090104920A (es) |
CN (1) | CN101652365A (es) |
AT (1) | ATE487720T1 (es) |
AU (1) | AU2008211729A1 (es) |
BR (1) | BRPI0807868A2 (es) |
CA (1) | CA2675677A1 (es) |
DE (1) | DE602008003404D1 (es) |
MX (1) | MX2009008084A (es) |
RU (1) | RU2009132605A (es) |
WO (1) | WO2008093075A2 (es) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102008061214A1 (de) * | 2008-12-09 | 2010-06-10 | Merck Patent Gmbh | Chinazolinamidderivate |
CA2753304C (en) | 2009-02-25 | 2014-07-15 | Daiichi Sankyo Company, Limited | Tricyclic pyrazolopyrimidine derivatives as hsp inhibitors |
AR077405A1 (es) | 2009-07-10 | 2011-08-24 | Sanofi Aventis | Derivados del indol inhibidores de hsp90, composiciones que los contienen y utilizacion de los mismos para el tratamiento del cancer |
FR2949467B1 (fr) | 2009-09-03 | 2011-11-25 | Sanofi Aventis | Nouveaux derives de 5,6,7,8-tetrahydroindolizine inhibiteurs d'hsp90, compositions les contenant et utilisation |
MX2012003484A (es) * | 2009-09-25 | 2012-04-20 | Vertex Pharma | Metodos para preparar derivados de pirimidina utiles como inhibidores de proteina cinasa. |
WO2012026433A1 (ja) | 2010-08-23 | 2012-03-01 | 第一三共株式会社 | 三環性ピラゾロピリミジン誘導体のフリー体結晶 |
CA2809120C (en) | 2010-08-23 | 2015-10-13 | Daiichi Sankyo Company, Limited | Crystal of tricyclic pyrazolopyrimidine derivative |
WO2012087943A2 (en) * | 2010-12-20 | 2012-06-28 | The Regents Of The University Of Michigan | Inhibitors of the epidermal growth factor receptor-heat shock protein 90 binding interaction |
EP2776444A4 (en) | 2011-11-10 | 2015-07-22 | Osi Pharmaceuticals Llc | dihydropteridinones |
AU2014228822A1 (en) | 2013-03-15 | 2015-10-01 | Memorial Sloan-Kettering Cancer Center | HSP90-targeted cardiac imaging and therapy |
WO2016044629A1 (en) | 2014-09-17 | 2016-03-24 | Memorial Sloan Kettering Cancer Center | Hsp90-targeted inflammation and infection imaging and therapy |
WO2017216726A1 (en) | 2016-06-13 | 2017-12-21 | Glaxosmithkline Intellectual Property Development Limited | Substituted pyridines as inhibitors of dnmt1 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU177986B (en) * | 1979-02-23 | 1982-02-28 | Egyt Gyogyszervegyeszeti Gyar | Process for preparing 1-acyl-1,2- or -1,4-dihydro-pyrido/3,4-e/-as-triazine derivatives |
JP2000154139A (ja) | 1998-09-16 | 2000-06-06 | Kyowa Hakko Kogyo Co Ltd | 縮環ピラジン誘導体 |
US6531475B1 (en) * | 1998-11-12 | 2003-03-11 | Neurocrine Biosciences, Inc. | CRF receptor antagonists and methods relating thereto |
DE69903333T2 (de) | 1998-11-12 | 2003-08-07 | Neurocrine Biosciences Inc | Crf rezeptor-antagonisten und darauf bezogene methoden |
AU2002228771B2 (en) | 2000-11-02 | 2007-10-25 | Sloan-Kettering Institute For Cancer Research | Small molecule compositions for binding to HSP90 |
US6806272B2 (en) * | 2001-09-04 | 2004-10-19 | Boehringer Ingelheim Pharma Kg | Dihydropteridinones, processes for preparing them and their use as pharmaceutical compositions |
US7241890B2 (en) | 2001-10-30 | 2007-07-10 | Conforma Therapeutics Corporation | Purine analogs having HSP90-inhibiting activity |
BRPI0413861A (pt) | 2003-08-29 | 2006-10-24 | Vernalis Cambridge Ltd | compostos de pirimidotiofeno |
KR20060070572A (ko) * | 2003-09-18 | 2006-06-23 | 콘포마 세러퓨틱스 코포레이션 | Hsp90-저해제로서의 신규 헤테로시클릭 화합물 |
DE102004058337A1 (de) | 2004-12-02 | 2006-06-14 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung von annelierten Piperazin-2-on Derivaten |
US7767687B2 (en) * | 2004-12-13 | 2010-08-03 | Biogen Idec Ma Inc. | Pyrido pyrimidinones, dihydro pyrimido pyrimidinones and pteridinones useful as RAF kinase inhibitors |
WO2006084030A2 (en) | 2005-02-01 | 2006-08-10 | Sloan-Kettering Institute For Cancer Research | Small-molecule hsp90 inhibitors |
NZ561939A (en) | 2005-03-30 | 2011-03-31 | Conforma Therapeutics Corp | Alkynyl pyrrolopyrimidines and related analogs as HSP90-inhibitors |
US20090215742A1 (en) | 2005-05-03 | 2009-08-27 | Pfizer, Inc. | Amide resorcinol compounds |
DE102005022977A1 (de) | 2005-05-19 | 2006-12-07 | Merck Patent Gmbh | Phenylchinazolinderivate |
EP1937258A2 (en) | 2005-09-23 | 2008-07-02 | Conforma Therapeutics Corporation | Anti-tumor methods using multi drug resistance independent synthetic hsp90 inhibitors |
US20070253896A1 (en) * | 2006-02-07 | 2007-11-01 | Conforma Therapeutics Corporation | 7,9-Dihydro-Purin-8-One and Related Analogs as HSP90-Inhibitors |
US7439358B2 (en) | 2006-02-08 | 2008-10-21 | Boehringer Ingelheim International Gmbh | Specific salt, anhydrous and crystalline form of a dihydropteridione derivative |
-
2008
- 2008-01-31 JP JP2009547752A patent/JP2010517989A/ja active Pending
- 2008-01-31 CA CA002675677A patent/CA2675677A1/en not_active Abandoned
- 2008-01-31 AT AT08701973T patent/ATE487720T1/de not_active IP Right Cessation
- 2008-01-31 US US12/023,202 patent/US7799781B2/en not_active Expired - Fee Related
- 2008-01-31 EP EP08701973A patent/EP2109612B1/en not_active Not-in-force
- 2008-01-31 WO PCT/GB2008/000303 patent/WO2008093075A2/en active Application Filing
- 2008-01-31 CN CN200880010915A patent/CN101652365A/zh active Pending
- 2008-01-31 KR KR1020097018333A patent/KR20090104920A/ko not_active Application Discontinuation
- 2008-01-31 RU RU2009132605/04A patent/RU2009132605A/ru not_active Application Discontinuation
- 2008-01-31 BR BRPI0807868-8A patent/BRPI0807868A2/pt not_active Application Discontinuation
- 2008-01-31 DE DE602008003404T patent/DE602008003404D1/de active Active
- 2008-01-31 MX MX2009008084A patent/MX2009008084A/es not_active Application Discontinuation
- 2008-01-31 AU AU2008211729A patent/AU2008211729A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
DE602008003404D1 (de) | 2010-12-23 |
AU2008211729A1 (en) | 2008-08-07 |
BRPI0807868A2 (pt) | 2013-10-15 |
US20080194572A1 (en) | 2008-08-14 |
ATE487720T1 (de) | 2010-11-15 |
RU2009132605A (ru) | 2011-03-10 |
CA2675677A1 (en) | 2008-08-07 |
EP2109612A2 (en) | 2009-10-21 |
US7799781B2 (en) | 2010-09-21 |
WO2008093075A3 (en) | 2008-10-02 |
CN101652365A (zh) | 2010-02-17 |
KR20090104920A (ko) | 2009-10-06 |
JP2010517989A (ja) | 2010-05-27 |
WO2008093075A2 (en) | 2008-08-07 |
EP2109612B1 (en) | 2010-11-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
HH | Correction or change in general | ||
FA | Abandonment or withdrawal |