EA201070423A1 - Диарильные соединения оксадиазолов - Google Patents

Диарильные соединения оксадиазолов

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Publication number
EA201070423A1
EA201070423A1 EA201070423A EA201070423A EA201070423A1 EA 201070423 A1 EA201070423 A1 EA 201070423A1 EA 201070423 A EA201070423 A EA 201070423A EA 201070423 A EA201070423 A EA 201070423A EA 201070423 A1 EA201070423 A1 EA 201070423A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compounds
diarylic
oxadiazoles
useful
formula
Prior art date
Application number
EA201070423A
Other languages
English (en)
Inventor
Сирил Монтань
Анна Кваттропани
Вольфганг Зауэр
Аньес Бомбрэн
Original Assignee
Мерк Сероно С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мерк Сероно С.А. filed Critical Мерк Сероно С.А.
Publication of EA201070423A1 publication Critical patent/EA201070423A1/ru

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    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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Abstract

Настоящее изобретение относится к соединениям формулы (I)где R, R, R, R, Rи W имеют обозначения по п.1. Соединения являются пригодными для использования, например, при лечении аутоиммунных расстройств, таких как рассеянный склероз.
EA201070423A 2007-10-04 2008-10-01 Диарильные соединения оксадиазолов EA201070423A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07117925 2007-10-04
US99813607P 2007-10-09 2007-10-09
PCT/EP2008/063185 WO2009043890A1 (en) 2007-10-04 2008-10-01 Oxadiazole diaryl compounds

Publications (1)

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EA201070423A1 true EA201070423A1 (ru) 2010-10-29

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US (2) US8404676B2 (ru)
EP (1) EP2193126B1 (ru)
JP (3) JP5727223B2 (ru)
KR (1) KR20100083814A (ru)
CN (2) CN104478821B (ru)
AR (1) AR068730A1 (ru)
AU (1) AU2008306886B2 (ru)
BR (1) BRPI0817597A2 (ru)
CA (1) CA2696829C (ru)
EA (1) EA201070423A1 (ru)
ES (1) ES2547877T3 (ru)
IL (1) IL204520A (ru)
MX (1) MX2010003614A (ru)
WO (1) WO2009043890A1 (ru)
ZA (1) ZA201001217B (ru)

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CA2696829C (en) * 2007-10-04 2017-07-04 Merck Serono S.A. Oxadiazole diaryl compounds
AU2008306885B2 (en) 2007-10-04 2013-12-05 Merck Serono S.A. Oxadiazole derivatives
US8551463B2 (en) 2007-10-22 2013-10-08 Living Proof, Inc. Hair care compositions and methods of treating hair
CN101918395B (zh) * 2007-12-21 2014-04-16 默克雪兰诺有限公司 ***联噁二唑衍生物
ES2389042T3 (es) * 2008-03-06 2012-10-22 Actelion Pharmaceuticals Ltd. Compuestos de piridina
US8410151B2 (en) 2008-03-07 2013-04-02 Actelion Pharmaceuticals Ltd Aminomethyl benzene derivatives
WO2010085582A1 (en) 2009-01-23 2010-07-29 Bristol-Myers Squibb Company Substituted oxadiazole derivatives as s1p agonists in the treatment of autoimmune and inflammatory diseases
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