EA200970271A1 - Получение вакцин против вируса гриппа без использования куриных эмбрионов - Google Patents

Получение вакцин против вируса гриппа без использования куриных эмбрионов

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Publication number
EA200970271A1
EA200970271A1 EA200970271A EA200970271A EA200970271A1 EA 200970271 A1 EA200970271 A1 EA 200970271A1 EA 200970271 A EA200970271 A EA 200970271A EA 200970271 A EA200970271 A EA 200970271A EA 200970271 A1 EA200970271 A1 EA 200970271A1
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EA
Eurasian Patent Office
Prior art keywords
influenza
chicken embryos
grown
virus
vaccines against
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EA200970271A
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English (en)
Inventor
Теодор Ф. Цай
Хайди Трусхайм
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Новартис Аг
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Application filed by Новартис Аг filed Critical Новартис Аг
Publication of EA200970271A1 publication Critical patent/EA200970271A1/ru

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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/145—Orthomyxoviridae, e.g. influenza virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/08—RNA viruses
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    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
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    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
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    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16211—Influenzavirus B, i.e. influenza B virus
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    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16211—Influenzavirus B, i.e. influenza B virus
    • C12N2760/16251—Methods of production or purification of viral material

Abstract

В настоящее время стадии осуществляемые перед высвобождением штаммов вируса гриппа, используемых для производства вакцины, включают пассирование вируса гриппа в куриных эмбрионах. Настоящее изобретение относится к разработке методик, применимых при производстве противогриппозных вакцин, в которых снижено использование куриных эмбрионов и предпочтительно они вообще не используются. Например, вместо использования куриных эмбрионов для выделения вируса для получения противогриппозной вакцины могут использоваться клетки MDCK (клетки почки собаки Madin Darby), такие как выращенные в суспензии, выращенные в бессывороточной среде, выращенные в безбелковой среде, которые при этом не являются онкогенными, выращенные в отсутствие двухфазной питательной среды и т.п.
EA200970271A 2006-09-11 2007-09-11 Получение вакцин против вируса гриппа без использования куриных эмбрионов EA200970271A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US84372006P 2006-09-11 2006-09-11
US93627907P 2007-06-18 2007-06-18
PCT/IB2007/003536 WO2008032219A2 (en) 2006-09-11 2007-09-11 Making influenza virus vaccines without using eggs

Publications (1)

Publication Number Publication Date
EA200970271A1 true EA200970271A1 (ru) 2010-02-26

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Country Status (12)

Country Link
US (3) US20100010199A1 (ru)
EP (3) EP2497495B3 (ru)
JP (7) JP5954921B2 (ru)
KR (1) KR20090057015A (ru)
AU (1) AU2007297178B2 (ru)
BR (1) BRPI0716536A2 (ru)
CA (2) CA3016948A1 (ru)
EA (1) EA200970271A1 (ru)
ES (2) ES2536401T3 (ru)
MX (1) MX2009002408A (ru)
NZ (1) NZ575271A (ru)
WO (1) WO2008032219A2 (ru)

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