EA200901459A1 - Реконструированные поверхностно-активные вещества, имеющие улучшенные свойства - Google Patents

Реконструированные поверхностно-активные вещества, имеющие улучшенные свойства

Info

Publication number
EA200901459A1
EA200901459A1 EA200901459A EA200901459A EA200901459A1 EA 200901459 A1 EA200901459 A1 EA 200901459A1 EA 200901459 A EA200901459 A EA 200901459A EA 200901459 A EA200901459 A EA 200901459A EA 200901459 A1 EA200901459 A1 EA 200901459A1
Authority
EA
Eurasian Patent Office
Prior art keywords
active substances
improved properties
reconstructed surface
directed
amino acid
Prior art date
Application number
EA200901459A
Other languages
English (en)
Other versions
EA017697B1 (ru
Inventor
Ян Йоханссон
Торе Курстедт
Бенгт Робертсон
Original Assignee
Кьези Фармачеутичи С. П. А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Кьези Фармачеутичи С. П. А. filed Critical Кьези Фармачеутичи С. П. А.
Publication of EA200901459A1 publication Critical patent/EA200901459A1/ru
Publication of EA017697B1 publication Critical patent/EA017697B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/785—Alveolar surfactant peptides; Pulmonary surfactant peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pulmonology (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Fire-Extinguishing Compositions (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)

Abstract

Настоящее изобретение относится к реконструированному поверхностно-активному веществу, содержащему липидный носитель, полипептидный аналог природного поверхностно-активного белка SP-C и полипептид, содержащий последовательность повторяющихся единиц, состоящих из ряда гидрофобных аминокислотных остатков в количестве от 3 до 8 и одного основного аминокислотного остатка. Изобретение также относится к содержащим его фармацевтическим композициям и его применению для профилактики и/или лечения RDS (респираторного дистресс-сидрома) и других респираторных расстройств.
EA200901459A 2007-06-01 2008-05-22 Реконструированные поверхностно-активные вещества, имеющие улучшенные свойства EA017697B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07010857A EP1997502A1 (en) 2007-06-01 2007-06-01 Reconstituted surfactants having improved properties
PCT/EP2008/004097 WO2008145298A1 (en) 2007-06-01 2008-05-22 Reconstituted surfactants having improved properties

Publications (2)

Publication Number Publication Date
EA200901459A1 true EA200901459A1 (ru) 2010-06-30
EA017697B1 EA017697B1 (ru) 2013-02-28

Family

ID=38421186

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200901459A EA017697B1 (ru) 2007-06-01 2008-05-22 Реконструированные поверхностно-активные вещества, имеющие улучшенные свойства

Country Status (14)

Country Link
US (1) US7897577B2 (ru)
EP (2) EP1997502A1 (ru)
JP (1) JP5575639B2 (ru)
KR (1) KR101516443B1 (ru)
CN (1) CN101687006B (ru)
AT (1) ATE544461T1 (ru)
AU (1) AU2008256449B2 (ru)
BR (1) BRPI0811320A2 (ru)
CA (1) CA2689066C (ru)
EA (1) EA017697B1 (ru)
HK (1) HK1140420A1 (ru)
MX (1) MX2009012675A (ru)
WO (1) WO2008145298A1 (ru)
ZA (1) ZA200908445B (ru)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20021058A1 (it) 2002-05-17 2003-11-17 Chiesi Farma Spa Miscele di lipidi sintetici ottimizzate per la preparazione di un surfattante ricostituito
ME02326B (me) 2006-10-13 2016-06-20 Chiesi Farm Spa Rekonstituisani surfaktanti sa poboljšanim svojstvima
EP2022798A1 (en) 2007-08-09 2009-02-11 CHIESI FARMACEUTICI S.p.A. Synthetic pulmonary surfactant peptides
WO2009049159A1 (en) * 2007-10-10 2009-04-16 Parion Sciences, Inc. Delivering osmolytes by nasal cannula
US8399406B2 (en) * 2009-06-05 2013-03-19 Chiesi Farmaceutici S.P.A. Reconstituted surfactant composition containing analogs of surfactant protein B (SP-B) and surfactant protein C (SP-C)
CA2838529C (en) 2011-06-07 2020-03-24 Parion Sciences, Inc. Methods of treatment
US8945605B2 (en) 2011-06-07 2015-02-03 Parion Sciences, Inc. Aerosol delivery systems, compositions and methods
AR086745A1 (es) 2011-06-27 2014-01-22 Parion Sciences Inc 3,5-diamino-6-cloro-n-(n-(4-(4-(2-(hexil(2,3,4,5,6-pentahidroxihexil)amino)etoxi)fenil)butil)carbamimidoil)pirazina-2-carboxamida
WO2013149013A1 (en) 2012-03-28 2013-10-03 Discovery Laboratories, Inc. Lyophilization of synthetic liposomal pulmonary surfactant
EA032734B1 (ru) 2012-05-29 2019-07-31 Парион Сайэнс, Инк. Дендримероподобные аминоамиды, обладающие активностью блокаторов натриевых каналов, для лечения сухости глаз и других заболеваний слизистых оболочек
KR102258469B1 (ko) 2012-12-17 2021-05-31 패리온 사이언스 인코퍼레이티드 불충분한 점막 수화에 의해 유발되는 질환의 치료에 유용한 클로로-피라진 카르복스아미드 유도체
EP3428153A1 (en) 2012-12-17 2019-01-16 Parion Sciences, Inc. 3,5-diamino-6-chloro-n-(n-(4-phenylbutyl)carbamimidoyl) pyrazine-2- carboxamide compounds
ES2674665T3 (es) 2012-12-17 2018-07-03 Parion Sciences, Inc. Compuestos de 3,5-diamino-6-cloro-N-(N-(4-fenilbutilo)carbamimidoilo)-pirazina-2-carboxamida
JP2017532981A (ja) 2014-10-01 2017-11-09 プラント ヘルス ケア インコーポレイテッド 破壊された過敏感反応ボックスを有するエリシターペプチド及びその使用
BR112017006575B1 (pt) * 2014-10-01 2023-11-21 Plant Health Care, Inc Peptídeo isolado, polipeptídeo de fusão, composição e métodos de conferir resistência à doença às plantas, de potencializar o crescimento da planta, de aumentar a tolerância da planta ao estresse biótico ou ao estresse abiótico e de modular a sinalização bioquímica da planta
US10793608B2 (en) 2016-04-06 2020-10-06 Plant Health Care, Inc. Hypersensitive response elicitor-derived peptides and use thereof
WO2017176588A1 (en) 2016-04-06 2017-10-12 Plant Health Care, Inc. Beneficial microbes for delivery of effector peptides or proteins and use thereof
PL3558376T3 (pl) 2016-12-22 2022-02-14 Chiesi Farmaceutici S.P.A. Kombinacja terapeutyczna zawierająca surfaktant płucny i steroid do leczenia rozwijającej się BPD
JP7378425B2 (ja) 2018-04-23 2023-11-13 シエシー ファルマセウティチィ ソシエタ ペル アチオニ 肺サーファクタントおよびｂｐｄの予防のためのステロイドを含む治療的組合せ
US20230097886A1 (en) * 2021-07-30 2023-03-30 Ayuvis Research, Inc. Compositions and methods for the treatment of bronchopulmonary dysplasia (bpd) and bpd-associated pulmonary hypertension

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5260273A (en) 1988-01-06 1993-11-09 The Scripps Research Institute Pulmonary surfactant protein and related polypeptide
IT1308180B1 (it) 1999-02-12 2001-12-07 Chiesi Farma Spa Peptidi sintetici aventi la capacita' di diminuire la tensionesuperficiale e loro impiego nella preparazione di un surfattante
EP1189625A1 (en) * 1999-06-11 2002-03-27 Byk Gulden Lomberg Chemische Fabrik GmbH Pharmaceutical preparation containing modifications of surfactant protein b (sp-b) and surfactant protein c (sp-c)
CN1838964A (zh) * 2002-04-25 2006-09-27 斯克里普斯研究学院 肺病的治疗与预防
ITMI20021058A1 (it) 2002-05-17 2003-11-17 Chiesi Farma Spa Miscele di lipidi sintetici ottimizzate per la preparazione di un surfattante ricostituito
EP1481665A1 (en) * 2003-05-30 2004-12-01 CHIESI FARMACEUTICI S.p.A. Novel lipid mixtures for synthetic surfactants
US7582312B2 (en) 2004-11-15 2009-09-01 Discovery Laboratories, Inc. Methods to produce lung surfactant formulations via lyophilization and formulations and uses thereof
ME02326B (me) * 2006-10-13 2016-06-20 Chiesi Farm Spa Rekonstituisani surfaktanti sa poboljšanim svojstvima
EP2022798A1 (en) 2007-08-09 2009-02-11 CHIESI FARMACEUTICI S.p.A. Synthetic pulmonary surfactant peptides

Also Published As

Publication number Publication date
EP2152288A1 (en) 2010-02-17
AU2008256449A1 (en) 2008-12-04
ZA200908445B (en) 2011-02-23
CA2689066C (en) 2016-03-29
KR101516443B1 (ko) 2015-05-07
CA2689066A1 (en) 2008-12-04
US20090088379A1 (en) 2009-04-02
WO2008145298A1 (en) 2008-12-04
EP1997502A1 (en) 2008-12-03
AU2008256449B2 (en) 2012-09-13
CN101687006A (zh) 2010-03-31
CN101687006B (zh) 2013-10-16
JP5575639B2 (ja) 2014-08-20
EA017697B1 (ru) 2013-02-28
JP2010528997A (ja) 2010-08-26
KR20100015802A (ko) 2010-02-12
HK1140420A1 (en) 2010-10-15
US7897577B2 (en) 2011-03-01
BRPI0811320A2 (pt) 2014-10-21
ATE544461T1 (de) 2012-02-15
EP2152288B1 (en) 2012-02-08
MX2009012675A (es) 2009-12-14

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM