EA200701819A1 - Новые соединения фосфиновой аминокислоты, способ их получения и фармацевтические композиции, содержащие их - Google Patents

Новые соединения фосфиновой аминокислоты, способ их получения и фармацевтические композиции, содержащие их

Info

Publication number
EA200701819A1
EA200701819A1 EA200701819A EA200701819A EA200701819A1 EA 200701819 A1 EA200701819 A1 EA 200701819A1 EA 200701819 A EA200701819 A EA 200701819A EA 200701819 A EA200701819 A EA 200701819A EA 200701819 A1 EA200701819 A1 EA 200701819A1
Authority
EA
Eurasian Patent Office
Prior art keywords
recovery
amino acids
pharmaceutical compositions
compositions containing
new compounds
Prior art date
Application number
EA200701819A
Other languages
English (en)
Other versions
EA012447B1 (ru
Inventor
Винсан Див
Никола Жюлльен
Элизабет Скальбер
Атанасиос Йотакис
Анастасиос Макаритис
Original Assignee
Ле Лаборатуар Сервье
Коммиссариа А Л`Энержи Атомик (Кэа)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ле Лаборатуар Сервье, Коммиссариа А Л`Энержи Атомик (Кэа) filed Critical Ле Лаборатуар Сервье
Publication of EA200701819A1 publication Critical patent/EA200701819A1/ru
Publication of EA012447B1 publication Critical patent/EA012447B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids R2P(=O)(OH); Thiophosphinic acids, i.e. R2P(=X)(XH) (X = S, Se)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07F9/653—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids R2P(=O)(OH); Thiophosphinic acids, i.e. R2P(=X)(XH) (X = S, Se)
    • C07F9/32—Esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6596—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having atoms other than oxygen, sulfur, selenium, tellurium, nitrogen or phosphorus as ring hetero atoms

Abstract

Соединения формулы (I):в которой Rпредставляет собой водород, алкилкарбонилоксиалкил или алкилкарбонилтиоалкил, Rпредставляет собой водород, алкилкарбонилоксиалкил, арилкарбонилтиоалкил или необязательно замещённый арилалкил, Rпредставляет собой фенил, который необязательно замещён, или индолил, их изомеры, а также их соли присоединения с фармацевтически приемлемой кислотой или основанием.
EA200701819A 2005-03-01 2006-02-28 Соединения фосфиновой аминокислоты и содержащие их фармацевтические композиции EA012447B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0502043A FR2882752B1 (fr) 2005-03-01 2005-03-01 Nouveaux derives d'aminoacides phosphiniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
PCT/FR2006/000446 WO2006092495A1 (fr) 2005-03-01 2006-02-28 Nouveaux derives d'aminoacides phosphiniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
EA200701819A1 true EA200701819A1 (ru) 2008-02-28
EA012447B1 EA012447B1 (ru) 2009-10-30

Family

ID=35033564

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200701819A EA012447B1 (ru) 2005-03-01 2006-02-28 Соединения фосфиновой аминокислоты и содержащие их фармацевтические композиции

Country Status (20)

Country Link
US (1) US7521469B2 (ru)
EP (1) EP1853615A1 (ru)
JP (1) JP4659843B2 (ru)
KR (1) KR20080011275A (ru)
CN (1) CN101133070A (ru)
AR (1) AR055565A1 (ru)
AU (1) AU2006219790B2 (ru)
BR (1) BRPI0607482A2 (ru)
CA (1) CA2601025C (ru)
EA (1) EA012447B1 (ru)
FR (1) FR2882752B1 (ru)
GE (1) GEP20105026B (ru)
MA (1) MA29315B1 (ru)
MX (1) MX2007010665A (ru)
MY (1) MY143558A (ru)
NO (1) NO20074942L (ru)
NZ (1) NZ560750A (ru)
UA (1) UA91214C2 (ru)
WO (1) WO2006092495A1 (ru)
ZA (1) ZA200707471B (ru)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2934267B1 (fr) * 2008-07-23 2010-08-13 Pharmaleads Derives aminophosphiniques utiles dans le traitement de la douleur

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5476847A (en) * 1994-06-29 1995-12-19 Schering Corporation Derivatives of phosphinic acid useful as endothelin converting enzyme inhibitors
IT1276710B1 (it) * 1995-06-14 1997-11-03 Zambon Spa Derivati dell'acido fosfinico ad attivita' inibitrice delle metallopeptidasi
FR2755135B1 (fr) * 1996-10-25 2002-12-27 Inst Nat Sante Rech Med Nouveaux derives d'(alpha-aminophosphino)peptides, leur procede de preparation et les compositions qui les contiennent

Also Published As

Publication number Publication date
NO20074942L (no) 2007-10-01
EP1853615A1 (fr) 2007-11-14
US7521469B2 (en) 2009-04-21
WO2006092495A1 (fr) 2006-09-08
MY143558A (en) 2011-05-31
AR055565A1 (es) 2007-08-22
FR2882752B1 (fr) 2007-05-04
JP2008531661A (ja) 2008-08-14
AU2006219790A1 (en) 2006-09-08
JP4659843B2 (ja) 2011-03-30
CA2601025C (fr) 2011-01-25
CN101133070A (zh) 2008-02-27
AU2006219790B2 (en) 2011-03-17
NZ560750A (en) 2010-12-24
KR20080011275A (ko) 2008-02-01
EA012447B1 (ru) 2009-10-30
CA2601025A1 (fr) 2006-09-08
GEP20105026B (en) 2010-06-25
UA91214C2 (ru) 2010-07-12
MX2007010665A (es) 2007-12-12
ZA200707471B (en) 2008-12-31
MA29315B1 (fr) 2008-03-03
FR2882752A1 (fr) 2006-09-08
BRPI0607482A2 (pt) 2009-09-08
US20080153890A1 (en) 2008-06-26

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Designated state(s): AM AZ BY KZ KG MD TJ TM RU