FR2882752B1 - Nouveaux derives d'aminoacides phosphiniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent - Google Patents

Nouveaux derives d'aminoacides phosphiniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Info

Publication number
FR2882752B1
FR2882752B1 FR0502043A FR0502043A FR2882752B1 FR 2882752 B1 FR2882752 B1 FR 2882752B1 FR 0502043 A FR0502043 A FR 0502043A FR 0502043 A FR0502043 A FR 0502043A FR 2882752 B1 FR2882752 B1 FR 2882752B1
Authority
FR
France
Prior art keywords
aminoacidic
derivatives
preparation
pharmaceutical compositions
compositions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0502043A
Other languages
English (en)
Other versions
FR2882752A1 (fr
Inventor
Vincent Dive
Nicolas Jullien
Elisabeth Scalbert
Athanasios Yiotakis
Anastasios Makaritis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Servier SAS
Commissariat a lEnergie Atomique et aux Energies Alternatives CEA
Original Assignee
Commissariat a lEnergie Atomique CEA
Laboratoires Servier SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Commissariat a lEnergie Atomique CEA, Laboratoires Servier SAS filed Critical Commissariat a lEnergie Atomique CEA
Priority to FR0502043A priority Critical patent/FR2882752B1/fr
Priority to MYPI20060824A priority patent/MY143558A/en
Priority to PCT/FR2006/000446 priority patent/WO2006092495A1/fr
Priority to GEAP200610296A priority patent/GEP20105026B/en
Priority to NZ560750A priority patent/NZ560750A/en
Priority to EA200701819A priority patent/EA012447B1/ru
Priority to JP2007557535A priority patent/JP4659843B2/ja
Priority to ZA200707471A priority patent/ZA200707471B/xx
Priority to KR1020077022456A priority patent/KR20080011275A/ko
Priority to BRPI0607482-0A priority patent/BRPI0607482A2/pt
Priority to US11/885,301 priority patent/US7521469B2/en
Priority to AU2006219790A priority patent/AU2006219790B2/en
Priority to CNA2006800068686A priority patent/CN101133070A/zh
Priority to CA2601025A priority patent/CA2601025C/fr
Priority to EP06725994A priority patent/EP1853615A1/fr
Priority to MX2007010665A priority patent/MX2007010665A/es
Priority to UAA200710758A priority patent/UA91214C2/ru
Priority to ARP060100755A priority patent/AR055565A1/es
Publication of FR2882752A1 publication Critical patent/FR2882752A1/fr
Application granted granted Critical
Publication of FR2882752B1 publication Critical patent/FR2882752B1/fr
Priority to MA30192A priority patent/MA29315B1/fr
Priority to NO20074942A priority patent/NO20074942L/no
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07F9/653—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids R2P(=O)(OH); Thiophosphinic acids, i.e. R2P(=X)(XH) (X = S, Se)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids R2P(=O)(OH); Thiophosphinic acids, i.e. R2P(=X)(XH) (X = S, Se)
    • C07F9/32—Esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6596—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having atoms other than oxygen, sulfur, selenium, tellurium, nitrogen or phosphorus as ring hetero atoms
FR0502043A 2005-03-01 2005-03-01 Nouveaux derives d'aminoacides phosphiniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent Expired - Fee Related FR2882752B1 (fr)

Priority Applications (20)

Application Number Priority Date Filing Date Title
FR0502043A FR2882752B1 (fr) 2005-03-01 2005-03-01 Nouveaux derives d'aminoacides phosphiniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
MYPI20060824A MY143558A (en) 2005-03-01 2006-02-27 Phosphinic amino acid compounds
CA2601025A CA2601025C (fr) 2005-03-01 2006-02-28 Nouveaux derives d'aminoacides phosphiniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
NZ560750A NZ560750A (en) 2005-03-01 2006-02-28 Novel derivatives of phosphinic amino acids, preparation method thereof and pharmaceutical compositions containing same
EA200701819A EA012447B1 (ru) 2005-03-01 2006-02-28 Соединения фосфиновой аминокислоты и содержащие их фармацевтические композиции
JP2007557535A JP4659843B2 (ja) 2005-03-01 2006-02-28 ホスフィニックアミノ酸（ｐｈｏｓｐｈｉｎｉｃａｍｉｎｏａｃｉｄｓ）の新規な誘導体、その製造方法およびそれを含有する医薬組成物
ZA200707471A ZA200707471B (en) 2005-03-01 2006-02-28 Novel derivatives of phosphinic amino acids, preparation method thereof and pharmaceutical compositions containing same
KR1020077022456A KR20080011275A (ko) 2005-03-01 2006-02-28 포스핀 아미노산의 유도체, 이의 제조 방법 및 이를함유하는 약제 조성물
BRPI0607482-0A BRPI0607482A2 (pt) 2005-03-01 2006-02-28 derivados de aminoácidos fosfìnicos, o respectivo processo de preparo e as composições farmacêuticas que os contêm
US11/885,301 US7521469B2 (en) 2005-03-01 2006-02-28 Phosphinic amino acid compounds
PCT/FR2006/000446 WO2006092495A1 (fr) 2005-03-01 2006-02-28 Nouveaux derives d'aminoacides phosphiniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CNA2006800068686A CN101133070A (zh) 2005-03-01 2006-02-28 新的次膦酸氨基酸衍生物、其制备方法以及含有它们的药物组合物
GEAP200610296A GEP20105026B (en) 2005-03-01 2006-02-28 Novel derivatives of phosphinic amino acids, preparation method thereof and pharmaceutical compositions containing same
EP06725994A EP1853615A1 (fr) 2005-03-01 2006-02-28 Nouveaux derives d'aminoacides phosphiniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
MX2007010665A MX2007010665A (es) 2005-03-01 2006-02-28 Nuevos derivados de aminoacidos fosfinicos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
UAA200710758A UA91214C2 (ru) 2005-03-01 2006-02-28 Соединения фосфиновой аминокислоты и фармацевтическая композиция, которая их содержит
AU2006219790A AU2006219790B2 (en) 2005-03-01 2006-02-28 Novel derivatives of phosphinic amino acids, preparation method thereof and pharmaceutical compositions containing same
ARP060100755A AR055565A1 (es) 2005-03-01 2006-03-01 Compuestos de aminoacidos fosfinicos a un procedimiento para su preparacion y a las composiciones farmaceuticas que los contienen
MA30192A MA29315B1 (fr) 2005-03-01 2007-09-06 Nouveaux derives d'aminoacides phosphiniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
NO20074942A NO20074942L (no) 2005-03-01 2007-10-01 Nye fosfinaminosyreforbindelser, fremgangsmate for deres fremstilling og farmasoytiske sammensetninger inneholdende dem

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0502043A FR2882752B1 (fr) 2005-03-01 2005-03-01 Nouveaux derives d'aminoacides phosphiniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
FR2882752A1 FR2882752A1 (fr) 2006-09-08
FR2882752B1 true FR2882752B1 (fr) 2007-05-04

Family

ID=35033564

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0502043A Expired - Fee Related FR2882752B1 (fr) 2005-03-01 2005-03-01 Nouveaux derives d'aminoacides phosphiniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Country Status (20)

Country Link
US (1) US7521469B2 (fr)
EP (1) EP1853615A1 (fr)
JP (1) JP4659843B2 (fr)
KR (1) KR20080011275A (fr)
CN (1) CN101133070A (fr)
AR (1) AR055565A1 (fr)
AU (1) AU2006219790B2 (fr)
BR (1) BRPI0607482A2 (fr)
CA (1) CA2601025C (fr)
EA (1) EA012447B1 (fr)
FR (1) FR2882752B1 (fr)
GE (1) GEP20105026B (fr)
MA (1) MA29315B1 (fr)
MX (1) MX2007010665A (fr)
MY (1) MY143558A (fr)
NO (1) NO20074942L (fr)
NZ (1) NZ560750A (fr)
UA (1) UA91214C2 (fr)
WO (1) WO2006092495A1 (fr)
ZA (1) ZA200707471B (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2934267B1 (fr) * 2008-07-23 2010-08-13 Pharmaleads Derives aminophosphiniques utiles dans le traitement de la douleur

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5476847A (en) * 1994-06-29 1995-12-19 Schering Corporation Derivatives of phosphinic acid useful as endothelin converting enzyme inhibitors
IT1276710B1 (it) * 1995-06-14 1997-11-03 Zambon Spa Derivati dell'acido fosfinico ad attivita' inibitrice delle metallopeptidasi
FR2755135B1 (fr) * 1996-10-25 2002-12-27 Inst Nat Sante Rech Med Nouveaux derives d'(alpha-aminophosphino)peptides, leur procede de preparation et les compositions qui les contiennent

Also Published As

Publication number Publication date
NO20074942L (no) 2007-10-01
EP1853615A1 (fr) 2007-11-14
US7521469B2 (en) 2009-04-21
WO2006092495A1 (fr) 2006-09-08
MY143558A (en) 2011-05-31
AR055565A1 (es) 2007-08-22
JP2008531661A (ja) 2008-08-14
AU2006219790A1 (en) 2006-09-08
JP4659843B2 (ja) 2011-03-30
CA2601025C (fr) 2011-01-25
CN101133070A (zh) 2008-02-27
AU2006219790B2 (en) 2011-03-17
EA200701819A1 (ru) 2008-02-28
NZ560750A (en) 2010-12-24
KR20080011275A (ko) 2008-02-01
EA012447B1 (ru) 2009-10-30
CA2601025A1 (fr) 2006-09-08
GEP20105026B (en) 2010-06-25
UA91214C2 (ru) 2010-07-12
MX2007010665A (es) 2007-12-12
ZA200707471B (en) 2008-12-31
MA29315B1 (fr) 2008-03-03
FR2882752A1 (fr) 2006-09-08
BRPI0607482A2 (pt) 2009-09-08
US20080153890A1 (en) 2008-06-26

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Effective date: 20111130