EA200701471A1 - Замещённые пиридинильные и пиримидинильные производные, используемые в качестве модуляторов метаболизма и лечение ассоциированных с ним расстройств - Google Patents
Замещённые пиридинильные и пиримидинильные производные, используемые в качестве модуляторов метаболизма и лечение ассоциированных с ним расстройствInfo
- Publication number
- EA200701471A1 EA200701471A1 EA200701471A EA200701471A EA200701471A1 EA 200701471 A1 EA200701471 A1 EA 200701471A1 EA 200701471 A EA200701471 A EA 200701471A EA 200701471 A EA200701471 A EA 200701471A EA 200701471 A1 EA200701471 A1 EA 200701471A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- modulators
- treatment
- substituted pyridinyl
- disorders associated
- metabolic disease
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Настоящее изобретение относится к некоторым замещенным пиридинильным и пиримидинильным производным формулы (Ia), которые являются модуляторами метаболизма. В соответствии с этим, соединения согласно изобретению могут быть использованы для лечения метаболических расстройств и их осложнений, таких как диабет и ожирение.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US64284005P | 2005-01-10 | 2005-01-10 | |
PCT/US2006/000567 WO2006083491A2 (en) | 2005-01-10 | 2006-01-09 | Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200701471A1 true EA200701471A1 (ru) | 2008-02-28 |
EA015714B1 EA015714B1 (ru) | 2011-10-31 |
Family
ID=36755755
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200701471A EA015714B1 (ru) | 2005-01-10 | 2006-01-09 | Замещённые пиридинильные и пиримидинильные производные, используемые в качестве модуляторов метаболизма, и лечение ассоциированных с ним рассройств |
Country Status (37)
Country | Link |
---|---|
US (3) | US20060155128A1 (ru) |
EP (2) | EP1911756B9 (ru) |
JP (1) | JP2008526882A (ru) |
KR (1) | KR20070098907A (ru) |
CN (2) | CN102125555A (ru) |
AR (1) | AR054320A1 (ru) |
AT (2) | ATE381558T1 (ru) |
AU (1) | AU2006211583C1 (ru) |
BR (1) | BRPI0606704A (ru) |
CA (1) | CA2594466A1 (ru) |
CR (1) | CR9225A (ru) |
CY (2) | CY1107215T1 (ru) |
DE (2) | DE602006000339T2 (ru) |
DK (2) | DK1732562T3 (ru) |
EA (1) | EA015714B1 (ru) |
ES (2) | ES2299167T4 (ru) |
GE (1) | GEP20094828B (ru) |
GT (1) | GT200600006A (ru) |
HK (2) | HK1094542A1 (ru) |
HN (2) | HN2006000969A (ru) |
HR (2) | HRP20080113T3 (ru) |
IL (1) | IL184363A0 (ru) |
MX (1) | MX2007008402A (ru) |
MY (1) | MY148521A (ru) |
NI (1) | NI200700169A (ru) |
NO (1) | NO20073806L (ru) |
NZ (1) | NZ556220A (ru) |
PE (2) | PE20060857A1 (ru) |
PL (2) | PL1911756T3 (ru) |
PT (2) | PT1732562E (ru) |
RS (2) | RS51007B (ru) |
SG (1) | SG158875A1 (ru) |
SI (2) | SI1911756T1 (ru) |
TW (1) | TW200637845A (ru) |
UA (1) | UA89812C2 (ru) |
WO (1) | WO2006083491A2 (ru) |
ZA (1) | ZA200705471B (ru) |
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