SI1606282T1 - Fenilni in piridilpiperidinski derivati kot modulatorji glukoznega metabolizma - Google Patents
Fenilni in piridilpiperidinski derivati kot modulatorji glukoznega metabolizmaInfo
- Publication number
- SI1606282T1 SI1606282T1 SI200431030T SI200431030T SI1606282T1 SI 1606282 T1 SI1606282 T1 SI 1606282T1 SI 200431030 T SI200431030 T SI 200431030T SI 200431030 T SI200431030 T SI 200431030T SI 1606282 T1 SI1606282 T1 SI 1606282T1
- Authority
- SI
- Slovenia
- Prior art keywords
- modulators
- derivatives
- pyridylpipereidinye
- phenyl
- glucose metabolism
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44978803P | 2003-02-24 | 2003-02-24 | |
| PCT/US2004/005555 WO2004076413A2 (en) | 2003-02-24 | 2004-02-23 | Phenyl- and pyridylpiperidine-derivatives as modulators of glucose metabolism |
| EP04713803A EP1606282B1 (en) | 2003-02-24 | 2004-02-23 | Phenyl- and pyridylpipereidinye-derivatives as modulators of glucose metabolism |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI1606282T1 true SI1606282T1 (sl) | 2009-04-30 |
Family
ID=32927568
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200431030T SI1606282T1 (sl) | 2003-02-24 | 2004-02-23 | Fenilni in piridilpiperidinski derivati kot modulatorji glukoznega metabolizma |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20070066590A1 (sl) |
| EP (1) | EP1606282B1 (sl) |
| JP (1) | JP2006518763A (sl) |
| KR (1) | KR20050106033A (sl) |
| CN (1) | CN1751038A (sl) |
| AT (1) | ATE414076T1 (sl) |
| AU (1) | AU2004215344B2 (sl) |
| BR (1) | BRPI0407620A (sl) |
| CA (1) | CA2515963A1 (sl) |
| CY (1) | CY1108736T1 (sl) |
| DE (1) | DE602004017703D1 (sl) |
| DK (1) | DK1606282T3 (sl) |
| EA (1) | EA200501348A1 (sl) |
| ES (1) | ES2316964T3 (sl) |
| HK (1) | HK1077305A1 (sl) |
| MX (1) | MXPA05007614A (sl) |
| PL (1) | PL378295A1 (sl) |
| PT (1) | PT1606282E (sl) |
| SI (1) | SI1606282T1 (sl) |
| WO (1) | WO2004076413A2 (sl) |
Families Citing this family (106)
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|---|---|---|---|---|
| FR2817257B1 (fr) | 2000-11-30 | 2009-03-20 | Sanofi Synthelabo | Cyclohexyl(alkyl)-propanolamines, leur preparation et compositions pharmaceutiques en contenant |
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| AR045047A1 (es) * | 2003-07-11 | 2005-10-12 | Arena Pharm Inc | Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos |
| TW200624427A (en) | 2004-09-20 | 2006-07-16 | Xenon Pharmaceuticals Inc | Heterocyclic derivatives and their use as therapeutic agents |
| BRPI0515482A (pt) | 2004-09-20 | 2008-07-22 | Xenon Pharmaceuticals Inc | derivados heterocìclicos e seus usos como agentes terapêuticos |
| WO2006034315A2 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-coa desaturase enzymes |
| US7829712B2 (en) | 2004-09-20 | 2010-11-09 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives for inhibiting human stearoyl-CoA-desaturase |
| BRPI0515488A (pt) | 2004-09-20 | 2008-07-29 | Xenon Pharmaceuticals Inc | derivados de heterocìclicos e seu uso como agentes terapêuticos |
| CN101083994A (zh) | 2004-09-20 | 2007-12-05 | 泽农医药公司 | 杂环衍生物及其用作硬脂酰CoA去饱和酶抑制剂的用途 |
| WO2006034338A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as mediators of stearoyl-coa desaturase |
| MX2007003913A (es) * | 2004-10-04 | 2007-05-21 | Hoffmann La Roche | Alquil-piridinas como inhibidores de 11 beta para diabetes. |
| NZ556017A (en) * | 2004-12-24 | 2009-10-30 | Prosidion Ltd | G-protein coupled receptor (gpr116) agonists and use thereof for treating obesity and diabetes |
| DOP2006000008A (es) * | 2005-01-10 | 2006-08-31 | Arena Pharm Inc | Terapia combinada para el tratamiento de la diabetes y afecciones relacionadas y para el tratamiento de afecciones que mejoran mediante un incremento de la concentración sanguínea de glp-1 |
| DOP2006000010A (es) * | 2005-01-10 | 2006-07-31 | Arena Pharm Inc | Procedimiento para preparar eteres aromáticos |
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| TWI417095B (zh) | 2006-03-15 | 2013-12-01 | Janssen Pharmaceuticals Inc | １，４-二取代之３-氰基-吡啶酮衍生物及其作為ｍＧｌｕＲ２-受體之正向異位性調節劑之用途 |
| AR060213A1 (es) | 2006-03-31 | 2008-06-04 | Glaxo Group Ltd | Compuesto de piperazinil - piridinil -bencensulfonamida , su uso para fabricar un medicamento proceso para la preparacion del mismo composicion farmaceutica que lo comprende y proceso para prepararla |
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-
2004
- 2004-02-23 CA CA002515963A patent/CA2515963A1/en not_active Withdrawn
- 2004-02-23 DK DK04713803T patent/DK1606282T3/da active
- 2004-02-23 ES ES04713803T patent/ES2316964T3/es not_active Expired - Lifetime
- 2004-02-23 AT AT04713803T patent/ATE414076T1/de active
- 2004-02-23 SI SI200431030T patent/SI1606282T1/sl unknown
- 2004-02-23 AU AU2004215344A patent/AU2004215344B2/en not_active Ceased
- 2004-02-23 PL PL378295A patent/PL378295A1/pl not_active Application Discontinuation
- 2004-02-23 WO PCT/US2004/005555 patent/WO2004076413A2/en active Application Filing
- 2004-02-23 CN CNA2004800044127A patent/CN1751038A/zh active Pending
- 2004-02-23 JP JP2006503856A patent/JP2006518763A/ja active Pending
- 2004-02-23 DE DE602004017703T patent/DE602004017703D1/de not_active Expired - Lifetime
- 2004-02-23 EA EA200501348A patent/EA200501348A1/ru unknown
- 2004-02-23 KR KR1020057015582A patent/KR20050106033A/ko not_active Application Discontinuation
- 2004-02-23 EP EP04713803A patent/EP1606282B1/en not_active Expired - Lifetime
- 2004-02-23 BR BRPI0407620-6A patent/BRPI0407620A/pt not_active IP Right Cessation
- 2004-02-23 PT PT04713803T patent/PT1606282E/pt unknown
- 2004-02-23 US US10/546,665 patent/US20070066590A1/en not_active Abandoned
- 2004-02-23 MX MXPA05007614A patent/MXPA05007614A/es active IP Right Grant
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2005
- 2005-12-28 HK HK05112041A patent/HK1077305A1/xx not_active IP Right Cessation
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2009
- 2009-01-29 CY CY20091100109T patent/CY1108736T1/el unknown
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| Publication number | Publication date |
|---|---|
| CY1108736T1 (el) | 2014-04-09 |
| WO2004076413A2 (en) | 2004-09-10 |
| CA2515963A1 (en) | 2004-09-10 |
| EA200501348A1 (ru) | 2006-02-24 |
| PT1606282E (pt) | 2009-02-10 |
| EP1606282A2 (en) | 2005-12-21 |
| DE602004017703D1 (de) | 2008-12-24 |
| EP1606282B1 (en) | 2008-11-12 |
| ES2316964T3 (es) | 2009-04-16 |
| CN1751038A (zh) | 2006-03-22 |
| KR20050106033A (ko) | 2005-11-08 |
| PL378295A1 (pl) | 2006-03-20 |
| WO2004076413A3 (en) | 2004-12-02 |
| BRPI0407620A (pt) | 2006-02-21 |
| US20070066590A1 (en) | 2007-03-22 |
| JP2006518763A (ja) | 2006-08-17 |
| DK1606282T3 (da) | 2009-03-16 |
| AU2004215344B2 (en) | 2010-06-24 |
| ATE414076T1 (de) | 2008-11-15 |
| MXPA05007614A (es) | 2006-05-25 |
| HK1077305A1 (en) | 2006-02-10 |
| AU2004215344A1 (en) | 2004-09-10 |
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