EA200401200A1 - Карбониламинопроизводные как новые ингибиторы гистондеацетилазы - Google Patents
Карбониламинопроизводные как новые ингибиторы гистондеацетилазыInfo
- Publication number
- EA200401200A1 EA200401200A1 EA200401200A EA200401200A EA200401200A1 EA 200401200 A1 EA200401200 A1 EA 200401200A1 EA 200401200 A EA200401200 A EA 200401200A EA 200401200 A EA200401200 A EA 200401200A EA 200401200 A1 EA200401200 A1 EA 200401200A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- histonedeacylase
- new inhibitors
- carbonylamino derivatives
- carbonylamino
- derivatives
- Prior art date
Links
- -1 CARBONYLAMINO Chemical class 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 102000003964 Histone deacetylase Human genes 0.000 abstract 1
- 108090000353 Histone deacetylase Proteins 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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Abstract
Данное изобретение относится к новым соединениям формулы (I)где n, m, t, R, R, R, R, R, L, Q, X, Y и (A) имеют определенные значения, обладающим ингибирующей ферментативной активностью в отношении гистондеацетилазы, их получению, композициям, содержащим указанные соединения, и их применению в качестве лекарственных средств.Международная заявка была опубликована вместе с отчетом о международном поиске.
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US36379902P | 2002-03-13 | 2002-03-13 | |
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PCT/EP2003/002512 WO2003076395A1 (en) | 2002-03-13 | 2003-03-11 | Carbonylamino-derivatives as novel inhibitors of histone deacetylase |
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EA200401200A1 true EA200401200A1 (ru) | 2005-02-24 |
EA007908B1 EA007908B1 (ru) | 2007-02-27 |
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EA200401200A EA007908B1 (ru) | 2002-03-13 | 2003-03-11 | Карбониламинопроизводные как новые ингибиторы гистондеацетилазы |
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CN (1) | CN100503599C (ru) |
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AU (1) | AU2003212336B2 (ru) |
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AU2002327627B2 (en) | 2001-09-14 | 2006-09-14 | Methylgene Inc. | Inhibitors of histone deacetylase |
US6897220B2 (en) | 2001-09-14 | 2005-05-24 | Methylgene, Inc. | Inhibitors of histone deacetylase |
US7868204B2 (en) | 2001-09-14 | 2011-01-11 | Methylgene Inc. | Inhibitors of histone deacetylase |
PL214279B1 (pl) | 2002-03-13 | 2013-07-31 | Janssen Pharmaceutica Nv | Pochodna sulfonyloaminowa, sposób jej wytwarzania i zastosowanie oraz kompozycja farmaceutyczna i sposób jej wytwarzania |
AU2003218735B2 (en) * | 2002-03-13 | 2009-03-12 | Janssen Pharmaceutica N.V. | Piperazinyl-, piperidinyl- and morpholinyl-derivatives as novel inhibitors of histone deacetylase |
KR20040090981A (ko) | 2002-03-13 | 2004-10-27 | 얀센 파마슈티카 엔.브이. | 신규한 히스톤 디아세틸라제 저해제로서의카보닐아미노-유도체 |
PL213783B1 (pl) | 2002-03-13 | 2013-05-31 | Janssen Pharmaceutica Nv | Podstawiona pochodna piperydyny lub piperazyny, jej zastosowanie i sposób wytwarzania oraz kompozycja farmaceutyczna |
TWI319387B (en) | 2002-04-05 | 2010-01-11 | Astrazeneca Ab | Benzamide derivatives |
US8163764B2 (en) * | 2002-04-26 | 2012-04-24 | Asan Laboratories Company (Cayman) Limited | Skincare methods |
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- 2003-03-11 PL PL370982A patent/PL205531B1/pl unknown
- 2003-03-11 JP JP2003574617A patent/JP4648628B2/ja not_active Expired - Lifetime
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- 2003-03-11 WO PCT/EP2003/002512 patent/WO2003076395A1/en active IP Right Grant
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- 2003-03-11 MX MXPA04008796A patent/MXPA04008796A/es active IP Right Grant
- 2003-03-11 BR BR0307607-5A patent/BR0307607A/pt not_active IP Right Cessation
- 2003-03-11 AU AU2003212336A patent/AU2003212336B2/en not_active Ceased
- 2003-03-11 CN CNB038058847A patent/CN100503599C/zh not_active Expired - Lifetime
- 2003-03-11 ES ES03708215T patent/ES2306858T3/es not_active Expired - Lifetime
- 2003-03-11 NZ NZ534831A patent/NZ534831A/en unknown
- 2003-03-11 EA EA200401200A patent/EA007908B1/ru not_active IP Right Cessation
- 2003-03-11 EP EP03708215A patent/EP1485348B1/en not_active Expired - Lifetime
- 2003-03-11 DE DE60321548T patent/DE60321548D1/de not_active Expired - Lifetime
- 2003-03-12 AR ARP030100852A patent/AR039564A1/es not_active Application Discontinuation
- 2003-03-12 TW TW092105281A patent/TW200404794A/zh unknown
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2004
- 2004-09-03 HR HR20040805A patent/HRP20040805A2/hr not_active Application Discontinuation
- 2004-09-30 NO NO20044146A patent/NO20044146L/no not_active Application Discontinuation
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2008
- 2008-09-19 US US12/233,977 patent/US8071615B2/en not_active Expired - Fee Related
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Also Published As
Publication number | Publication date |
---|---|
NZ534831A (en) | 2007-01-26 |
EP1485348A1 (en) | 2004-12-15 |
CA2476067C (en) | 2011-09-20 |
OA12789A (en) | 2006-07-10 |
WO2003076395A1 (en) | 2003-09-18 |
US7446109B2 (en) | 2008-11-04 |
KR20040090981A (ko) | 2004-10-27 |
AU2003212336B2 (en) | 2008-12-18 |
ES2306858T3 (es) | 2008-11-16 |
NO20044146L (no) | 2004-09-30 |
CN1642907A (zh) | 2005-07-20 |
PL370982A1 (en) | 2005-06-13 |
BR0307607A (pt) | 2004-12-21 |
EA007908B1 (ru) | 2007-02-27 |
US20090042920A1 (en) | 2009-02-12 |
DK1485348T3 (da) | 2008-09-29 |
PL205531B1 (pl) | 2010-04-30 |
AU2003212336A1 (en) | 2003-09-22 |
US8071615B2 (en) | 2011-12-06 |
CN100503599C (zh) | 2009-06-24 |
DE60321548D1 (de) | 2008-07-24 |
EP1485348B1 (en) | 2008-06-11 |
ATE398105T1 (de) | 2008-07-15 |
CA2476067A1 (en) | 2003-09-18 |
TW200404794A (en) | 2004-04-01 |
US20120041001A1 (en) | 2012-02-16 |
AR039564A1 (es) | 2005-02-23 |
JP4648628B2 (ja) | 2011-03-09 |
US20050148613A1 (en) | 2005-07-07 |
JP2005519950A (ja) | 2005-07-07 |
MXPA04008796A (es) | 2004-11-26 |
HRP20040805A2 (en) | 2005-04-30 |
US8394831B2 (en) | 2013-03-12 |
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