EA200501669A1 - Замещенные производные индолина и индола - Google Patents

Замещенные производные индолина и индола

Info

Publication number
EA200501669A1
EA200501669A1 EA200501669A EA200501669A EA200501669A1 EA 200501669 A1 EA200501669 A1 EA 200501669A1 EA 200501669 A EA200501669 A EA 200501669A EA 200501669 A EA200501669 A EA 200501669A EA 200501669 A1 EA200501669 A1 EA 200501669A1
Authority
EA
Eurasian Patent Office
Prior art keywords
indoline
indol
substituted derivatives
pharmaceutically acceptable
general formula
Prior art date
Application number
EA200501669A
Other languages
English (en)
Russian (ru)
Inventor
Николай Ханжин
Марио Роттлендер
Уилльям Патрик Ватсон
Original Assignee
Х. Лундбекк А/С
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Х. Лундбекк А/С filed Critical Х. Лундбекк А/С
Priority claimed from PCT/DK2004/000283 external-priority patent/WO2004096767A1/fr
Publication of EA200501669A1 publication Critical patent/EA200501669A1/ru

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/08Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404Indoles, e.g. pindolol
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
EA200501669A 2003-04-25 2004-04-23 Замещенные производные индолина и индола EA200501669A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200300631 2003-04-25
PCT/DK2004/000283 WO2004096767A1 (fr) 2003-04-25 2004-04-23 Derives indole et indoline substitues

Publications (1)

Publication Number Publication Date
EA200501669A1 true EA200501669A1 (ru) 2006-04-28

Family

ID=58707218

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200501669A EA200501669A1 (ru) 2003-04-25 2004-04-23 Замещенные производные индолина и индола

Country Status (10)

Country Link
KR (1) KR20060004957A (fr)
CN (1) CN1777582A (fr)
AR (1) AR044517A1 (fr)
BR (1) BRPI0409317A (fr)
CA (1) CA2523102A1 (fr)
EA (1) EA200501669A1 (fr)
IS (1) IS8002A (fr)
NZ (1) NZ541999A (fr)
UA (1) UA80190C2 (fr)
ZA (1) ZA200507186B (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103508960B (zh) * 2012-06-29 2017-12-12 江苏先声药业有限公司 苯并杂环衍生物
CN108863893A (zh) * 2018-07-09 2018-11-23 湖南博隽生物医药有限公司 二氢吲哚类衍生物及其在药物中的应用
CN112010808B (zh) * 2019-05-31 2021-11-30 上海挚盟医药科技有限公司 作为钾通道调节剂的四氢-1h-苯氮杂卓类化合物及其制备和应用

Also Published As

Publication number Publication date
CA2523102A1 (fr) 2004-11-11
UA80190C2 (en) 2007-08-27
ZA200507186B (en) 2006-11-29
CN1777582A (zh) 2006-05-24
AR044517A1 (es) 2005-09-14
IS8002A (is) 2005-08-29
KR20060004957A (ko) 2006-01-16
BRPI0409317A (pt) 2006-04-25
NZ541999A (en) 2009-03-31

Similar Documents

Publication Publication Date Title
NO20055562L (no) Substituerte indolin- og indolderivater
EA200601686A1 (ru) Замещенные производные морфолина и тиоморфолина
CY1110977T1 (el) Υποκατεστημενα παραγωγα ινδολης για φαρμακευτικη συνθεση για θεραπεια ασθενειων του αναπνευστικου
BRPI0414817A (pt) derivados de ácido indol substituìdos e seu uso como inibidores de pai-l
CY1110104T1 (el) Παραγωγα της πιπεραζινης ως αναστολεις ταχυκινινων
NO20054848L (no) Substituerte p-diaminobenzenderivater
EA200800760A1 (ru) ПИРИДОПИРИМИДИНОНОВЫЕ ИНГИБИТОРЫ PI3Kα
EA200700188A1 (ru) Производные замещенного 2-алкилхиназолинона как ингибиторы parp
ATE517882T1 (de) Chinolinderivate
EA201171081A1 (ru) Производные индола в качестве антагонистов рецептора crth2
NO20050666L (no) 2,7-substituerte indoler og deres anvendelse som 5-HT6 modulatorer
ATE449776T1 (de) Pyrroloä2,3-cüpyridinderivate
ATE467632T1 (de) Pyrroloä2,3-büpyridinderivate als modulatoren des h3-rezeptors
EA200700400A1 (ru) Производные n-(1h-индолил)-1н-индол-2-карбоксамидов, их получение и их применение в терапии
ATE374190T1 (de) Tetrahydrochinazolinderivate als cfr-antagonisten
ATE466007T1 (de) 5-substituierte indol-2-carbonsäureamidderivate
ATE492534T1 (de) 1h-indol-5-ylpiperazin-1-ylmethanonderivate
NO20054721L (no) Substituerte anilinderivater
MXPA05009282A (es) Derivados de anilina sustituidos.
EA200700555A1 (ru) Производные индола в качестве ингибиторов растворимой аденилатциклазы
EA200501900A1 (ru) Новый способ синтеза периндоприла и его фармацевтически приемлемых солей
EA200501925A1 (ru) Новый способ синтеза периндоприла и его фармацевтически приемлемых солей
EA200600898A1 (ru) Новый способ синтеза периндоприла и его фармацевтически приемлемых солей
ATE465151T1 (de) 4-aryloxy-chinolin-derivate als 5-ht6-modulatoren
EA200501557A1 (ru) Новый способ синтеза (2s)-индолин-2-карбоновой кислоты и использование в синтезе периндоприла