SI1564203T1 - Nov postopek za sintezo metoksi naftil acetonitrila in uporaba pri sintezi agomelatina - Google Patents

Nov postopek za sintezo metoksi naftil acetonitrila in uporaba pri sintezi agomelatina

Info

Publication number: SI1564203T1
Authority: SI; Slovenia
Prior art keywords: agomelatine; naphtyl; synthesizing; acetonitrile; methoxy
Prior art date: 2004-02-13

Application number

SI200530911T

Other languages

English (en)

Inventor

Jean-Claude Souvie

Blanco Isaac Gonzalez

Original Assignee

Servier Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-02-13

Filing date

2005-02-11

Publication date

2010-03-31

2005-02-11 Application filed by Servier Lab filed Critical Servier Lab

2010-03-31 Publication of SI1564203T1 publication Critical patent/SI1564203T1/sl

Links

WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 title 3
YJYPHIXNFHFHND-UHFFFAOYSA-N agomelatine Chemical compound C1=CC=C(CCNC(C)=O)C2=CC(OC)=CC=C21 YJYPHIXNFHFHND-UHFFFAOYSA-N 0.000 title 1
229960002629 agomelatine Drugs 0.000 title 1
230000015572 biosynthetic process Effects 0.000 title 1
238000000034 method Methods 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1
230000002194 synthesizing effect Effects 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
- F16B—DEVICES FOR FASTENING OR SECURING CONSTRUCTIONAL ELEMENTS OR MACHINE PARTS TOGETHER, e.g. NAILS, BOLTS, CIRCLIPS, CLAMPS, CLIPS OR WEDGES; JOINTS OR JOINTING
- F16B37/00—Nuts or like thread-engaging members
- F16B37/14—Cap nuts; Nut caps or bolt caps
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/37—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by etherified hydroxy groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

SI200530911T 2004-02-13 2005-02-11 Nov postopek za sintezo metoksi naftil acetonitrila in uporaba pri sintezi agomelatina SI1564203T1 (sl)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR0401438A FR2866334B1 (fr)	2004-02-13	2004-02-13	Nouveau procede de synthese du (7-methoxy-1-naphtyl) acetonitrile et application a la synthese de l'agomelatine
EP05290307A EP1564203B1 (fr)	2004-02-13	2005-02-11	Nouveau procédé de synthèse du (7-méthoxy-1-naphtyl)acétonitrile et application à la synthèse de l'agomélatine

Publications (1)

Publication Number	Publication Date
SI1564203T1 true SI1564203T1 (sl)	2010-03-31

Family

ID=34685018

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SI200530911T SI1564203T1 (sl)	2004-02-13	2005-02-11	Nov postopek za sintezo metoksi naftil acetonitrila in uporaba pri sintezi agomelatina

Country Status (33)

Country	Link
US (2)	US7476751B2 (sl)
EP (1)	EP1564203B1 (sl)
JP (1)	JP4252040B2 (sl)
KR (1)	KR100682697B1 (sl)
CN (1)	CN1315794C (sl)
AR (1)	AR047667A1 (sl)
AT (1)	ATE452873T1 (sl)
AU (1)	AU2005200620B8 (sl)
BR (1)	BRPI0500395B8 (sl)
CA (1)	CA2495960C (sl)
CY (1)	CY1109737T1 (sl)
DE (1)	DE602005018403D1 (sl)
DK (1)	DK1564203T3 (sl)
EA (1)	EA007789B1 (sl)
ES (1)	ES2338664T3 (sl)
FR (1)	FR2866334B1 (sl)
GE (1)	GEP20063961B (sl)
HK (1)	HK1079187A1 (sl)
HR (1)	HRP20100103T1 (sl)
MA (1)	MA27517A1 (sl)
ME (1)	ME01806B (sl)
MX (1)	MXPA05001634A (sl)
MY (2)	MY142270A (sl)
NO (1)	NO333488B1 (sl)
NZ (1)	NZ538192A (sl)
PL (1)	PL1564203T3 (sl)
PT (1)	PT1564203E (sl)
RS (1)	RS51212B (sl)
SG (1)	SG114702A1 (sl)
SI (1)	SI1564203T1 (sl)
UA (1)	UA79479C2 (sl)
WO (1)	WO2005077890A1 (sl)
ZA (1)	ZA200501256B (sl)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2866336B1 (fr) *	2004-02-13	2006-03-24	Servier Lab	Nouveau procede de synthese du (7-methoxy-3,4-dihydro-1-naphtalenyl) acetonitrile et application a la synthese de l'agomelatine
CN101161638B (zh) *	2006-10-13	2010-09-29	北京德众万全药物技术开发有限公司	一种新的阿戈美拉汀重要中间体的制备方法
CN101585779B (zh) *	2009-03-10	2014-04-02	上海医药工业研究院	阿戈美拉汀的晶型vi及其制备方法和应用
CN101723855B (zh) *	2009-12-03	2012-08-08	浙江科技学院	一种(7-甲氧基-1-萘基)乙腈的合成方法
CN101792400B (zh) *	2010-03-16	2013-01-30	华东师范大学	一种阿戈美拉汀的合成方法
CN102276492B (zh)	2010-06-08	2013-04-10	上海医药工业研究院	阿戈美拉汀中间体及其制备方法
CL2011001405A1 (es)	2010-06-10	2012-03-30	Gador S A Conicet	Procedimiento para la preparacion de n-[2-(7-metoxi-1-naftil)etil]acetamida, agometalina.
CN102060733B (zh) *	2010-12-06	2014-01-29	威海迪素制药有限公司	(7-甲氧基-3,4-二氢-1-萘基)乙腈的制备方法
FR2970000B1 (fr)	2011-01-05	2013-01-04	Servier Lab	Nouveau procede de synthese de l'agomelatine
WO2013054273A2 (en)	2011-10-11	2013-04-18	Ranbaxy Laboratories Limited	Process for the preparation of agomelatine
EP2785681A1 (en)	2011-12-01	2014-10-08	Ranbaxy Laboratories Limited	Process for the preparation of agomelatine
CN103319370B (zh) *	2012-03-21	2016-08-03	黑龙江福和华星制药集团股份有限公司	一种(7-甲氧基-1-萘基)乙腈的制备方法
ITMI20121444A1 (it)	2012-08-27	2014-02-28	Procos Spa	Processo per la produzione di agomelatine
CN102875415B (zh) *	2012-10-09	2014-08-20	江西同和药业有限责任公司	一种化合物及其制备方法和应用
CN102875408B (zh) *	2012-10-09	2014-07-16	江西同和药业有限责任公司	一种阿戈美拉汀的制备方法
WO2016046833A2 (en) *	2014-09-24	2016-03-31	Symed Labs Limited	Improved processes for the preparation of agomelatine using novel intermediates

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4327022A (en) *	1973-08-16	1982-04-27	Sterling Drug Inc.	Heterocyclic alkyl naphthols
US3931188A (en) *	1974-05-06	1976-01-06	Bristol-Myers Company	3-Hydroxy-5,6-benzomorphinan derivatives
US3992403A (en) *	1975-05-30	1976-11-16	Schering Corporation	2-Imidazolines and their use as hypoglycemic agents
FR2658818B1 (fr) *	1990-02-27	1993-12-31	Adir Cie	Nouveaux derives a structure naphtalenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
FR2866335B1 (fr) *	2004-02-13	2006-05-26	Servier Lab	Nouveau procede de synthese de l'agomelatine
FR2866336B1 (fr) *	2004-02-13	2006-03-24	Servier Lab	Nouveau procede de synthese du (7-methoxy-3,4-dihydro-1-naphtalenyl) acetonitrile et application a la synthese de l'agomelatine

2004
- 2004-02-13 FR FR0401438A patent/FR2866334B1/fr not_active Expired - Fee Related
2005
- 2005-02-03 CA CA002495960A patent/CA2495960C/fr active Active
- 2005-02-07 SG SG200500676A patent/SG114702A1/en unknown
- 2005-02-07 MY MYPI20050477A patent/MY142270A/en unknown
- 2005-02-07 MY MYPI20091874A patent/MY143737A/en unknown
- 2005-02-07 US US11/052,629 patent/US7476751B2/en active Active
- 2005-02-10 MX MXPA05001634A patent/MXPA05001634A/es active IP Right Grant
- 2005-02-11 ES ES05290307T patent/ES2338664T3/es active Active
- 2005-02-11 ME MEP-2010-42A patent/ME01806B/me unknown
- 2005-02-11 AT AT05290307T patent/ATE452873T1/de active
- 2005-02-11 EP EP05290307A patent/EP1564203B1/fr active Active
- 2005-02-11 DE DE602005018403T patent/DE602005018403D1/de active Active
- 2005-02-11 SI SI200530911T patent/SI1564203T1/sl unknown
- 2005-02-11 UA UAA200501278A patent/UA79479C2/uk unknown
- 2005-02-11 AU AU2005200620A patent/AU2005200620B8/en active Active
- 2005-02-11 RS RSP-2010/0042A patent/RS51212B/sr unknown
- 2005-02-11 DK DK05290307.7T patent/DK1564203T3/da active
- 2005-02-11 NO NO20050740A patent/NO333488B1/no unknown
- 2005-02-11 PL PL05290307T patent/PL1564203T3/pl unknown
- 2005-02-11 MA MA28100A patent/MA27517A1/fr unknown
- 2005-02-11 GE GEAP8624A patent/GEP20063961B/en unknown
- 2005-02-11 PT PT05290307T patent/PT1564203E/pt unknown
- 2005-02-11 WO PCT/FR2005/000326 patent/WO2005077890A1/fr active Application Filing
- 2005-02-11 AR ARP050100501A patent/AR047667A1/es unknown
- 2005-02-11 ZA ZA2005/01256A patent/ZA200501256B/en unknown
- 2005-02-11 NZ NZ538192A patent/NZ538192A/en unknown
- 2005-02-12 KR KR1020050011748A patent/KR100682697B1/ko active Protection Beyond IP Right Term
- 2005-02-14 EA EA200500201A patent/EA007789B1/ru unknown
- 2005-02-14 JP JP2005035757A patent/JP4252040B2/ja active Active
- 2005-02-14 BR BRPI0500395A patent/BRPI0500395B8/pt active IP Right Grant
- 2005-02-16 CN CNB200510007756XA patent/CN1315794C/zh active Active
- 2005-12-06 HK HK05111121A patent/HK1079187A1/xx unknown
2008
- 2008-12-09 US US12/315,983 patent/US7999129B2/en active Active
2010
- 2010-01-19 CY CY20101100052T patent/CY1109737T1/el unknown
- 2010-02-26 HR HR20100103T patent/HRP20100103T1/hr unknown

Also Published As

Publication number	Publication date
CY1109737T1 (el)	2014-09-10
US20050182267A1 (en)	2005-08-18
JP2005239718A (ja)	2005-09-08
NZ538192A (en)	2005-12-23
FR2866334A1 (fr)	2005-08-19
SG114702A1 (en)	2005-09-28
ME01806B (me)	2010-12-31
PT1564203E (pt)	2010-01-15
EP1564203A1 (fr)	2005-08-17
HRP20100103T1 (hr)	2010-04-30
BRPI0500395B1 (pt)	2018-11-06
AR047667A1 (es)	2006-02-01
PL1564203T3 (pl)	2010-06-30
RS51212B (sr)	2010-12-31
US20090131719A1 (en)	2009-05-21
ZA200501256B (en)	2005-11-30
MXPA05001634A (es)	2005-08-19
JP4252040B2 (ja)	2009-04-08
DK1564203T3 (da)	2010-04-12
NO333488B1 (no)	2013-06-24
HK1079187A1 (en)	2006-03-31
NO20050740L (no)	2005-08-15
KR20060041902A (ko)	2006-05-12
EA200500201A1 (ru)	2005-08-25
EP1564203B1 (fr)	2009-12-23
KR100682697B1 (ko)	2007-02-15
US7476751B2 (en)	2009-01-13
BRPI0500395B8 (pt)	2021-05-25
MY143737A (en)	2011-07-04
ATE452873T1 (de)	2010-01-15
WO2005077890A1 (fr)	2005-08-25
MY142270A (en)	2010-11-15
BRPI0500395A (pt)	2005-09-27
AU2005200620A8 (en)	2011-06-02
US7999129B2 (en)	2011-08-16
CA2495960A1 (fr)	2005-08-13
GEP20063961B (en)	2006-11-10
FR2866334B1 (fr)	2006-05-26
AU2005200620B2 (en)	2011-05-19
CN1315794C (zh)	2007-05-16
CN1680296A (zh)	2005-10-12
EA007789B1 (ru)	2007-02-27
CA2495960C (fr)	2007-11-27
ES2338664T3 (es)	2010-05-11
DE602005018403D1 (de)	2010-02-04
MA27517A1 (fr)	2005-09-01
UA79479C2 (en)	2007-06-25
NO20050740D0 (no)	2005-02-11
AU2005200620A1 (en)	2005-09-01
AU2005200620B8 (en)	2011-06-02

Publication	Publication Date	Title
ME01806B (me)	2010-12-31	Novi postupak sinteze (7-metoksi-1-naftil) acetonitrila i primena u sintezi agomelatina
SI1564204T1 (sl)	2008-04-30	Nov postopek za sintezo (7-metoksi-3,4-dihidro-1-naftalenil)-acetonitrila in njegova uporaba za sintezo aglomelatina
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