EA200300525A1 - Гликозидирование индолкарбазола с применением межфазного катализа - Google Patents

Гликозидирование индолкарбазола с применением межфазного катализа

Info

Publication number
EA200300525A1
EA200300525A1 EA200300525A EA200300525A EA200300525A1 EA 200300525 A1 EA200300525 A1 EA 200300525A1 EA 200300525 A EA200300525 A EA 200300525A EA 200300525 A EA200300525 A EA 200300525A EA 200300525 A1 EA200300525 A1 EA 200300525A1
Authority
EA
Eurasian Patent Office
Prior art keywords
glycosidation
indolcarbazole
interphase
catalysis
interphase catalysis
Prior art date
Application number
EA200300525A
Other languages
English (en)
Other versions
EA005209B1 (ru
Inventor
Дэниел Е. Петрилло
Стивен А. Вайссман
Кай Россен
Соуити Хирага
Нобуя Сатаке
Original Assignee
Мерк Энд Ко., Инк.
Баниу Фармасьютикал Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мерк Энд Ко., Инк., Баниу Фармасьютикал Ко., Лтд. filed Critical Мерк Энд Ко., Инк.
Publication of EA200300525A1 publication Critical patent/EA200300525A1/ru
Publication of EA005209B1 publication Critical patent/EA005209B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Настоящее изобретение относится к новому способу гликозидирования для получения промежуточных соединений, пригодных для изготовления производных индолпирролкарбазола, ингибирующих рост опухолевых клеток и, следовательно, пригодных для лечения злокачественных опухолей млекопитающих и им подобных.Отчет о международном поиске был опубликован 2002.11.28.
EA200300525A 2000-10-31 2001-10-26 Гликозидирование индолкарбазола с применением межфазного катализа EA005209B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24467500P 2000-10-31 2000-10-31
PCT/US2001/047603 WO2002036601A2 (en) 2000-10-31 2001-10-26 Phase transfer catalyzed glycosidation of an indolocarbazole

Publications (2)

Publication Number Publication Date
EA200300525A1 true EA200300525A1 (ru) 2003-08-28
EA005209B1 EA005209B1 (ru) 2004-12-30

Family

ID=22923680

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200300525A EA005209B1 (ru) 2000-10-31 2001-10-26 Гликозидирование индолкарбазола с применением межфазного катализа

Country Status (21)

Country Link
US (2) US6555677B2 (ru)
EP (1) EP1333826A2 (ru)
JP (1) JP3554560B2 (ru)
KR (1) KR100813086B1 (ru)
CN (1) CN1240380C (ru)
AU (2) AU2894502A (ru)
BG (1) BG107737A (ru)
BR (1) BR0115036A (ru)
CA (1) CA2426815A1 (ru)
CZ (1) CZ20031209A3 (ru)
EA (1) EA005209B1 (ru)
HK (1) HK1064053A1 (ru)
HU (1) HUP0302923A3 (ru)
IL (1) IL155543A0 (ru)
IS (1) IS6791A (ru)
MX (1) MXPA03003871A (ru)
NO (1) NO20031922L (ru)
NZ (1) NZ525398A (ru)
PL (1) PL365574A1 (ru)
WO (1) WO2002036601A2 (ru)
ZA (1) ZA200303198B (ru)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6555677B2 (en) * 2000-10-31 2003-04-29 Merck & Co., Inc. Phase transfer catalyzed glycosidation of an indolocarbazole
RU2358979C2 (ru) 2003-05-30 2009-06-20 Фармассет, Инк. Модифицированные фторированные аналоги нуклеозида
CN1852914A (zh) * 2003-09-16 2006-10-25 万有制药株式会社 抗肿瘤性新型吲哚并吡咯并咔唑衍生物
EP1754711A4 (en) * 2004-05-28 2010-06-23 Banyu Pharma Co Ltd PROCESS FOR THE PREPARATION OF AN INDOLOPYRROLOCARBAZOLE DERIVATIVE
CN101023094B (zh) * 2004-07-21 2011-05-18 法莫赛特股份有限公司 烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备
KR101177590B1 (ko) * 2004-09-14 2012-08-27 파마셋 인코포레이티드 2'-플루오로-2'-알킬 치환되거나 또는 다른 선택적으로치환된 리보퓨라노실 피리미딘 및 퓨린 및 그 유도체의제조
US7537774B2 (en) * 2005-12-23 2009-05-26 Orion Therapeautics, Llc Therapeutic formulation
US7964580B2 (en) 2007-03-30 2011-06-21 Pharmasset, Inc. Nucleoside phosphoramidate prodrugs
US8173621B2 (en) * 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
US8551973B2 (en) 2008-12-23 2013-10-08 Gilead Pharmasset Llc Nucleoside analogs
KR20110104074A (ko) 2008-12-23 2011-09-21 파마셋 인코포레이티드 퓨린 뉴클레오시드의 합성
PA8855601A1 (es) 2008-12-23 2010-07-27 Forformidatos de nucleósidos
US8618076B2 (en) 2009-05-20 2013-12-31 Gilead Pharmasset Llc Nucleoside phosphoramidates
TWI583692B (zh) 2009-05-20 2017-05-21 基利法瑪席特有限責任公司 核苷磷醯胺
US8563530B2 (en) 2010-03-31 2013-10-22 Gilead Pharmassel LLC Purine nucleoside phosphoramidate
CA2794671C (en) 2010-03-31 2018-05-01 Gilead Pharmasset Llc Stereoselective synthesis of phosphorus containing actives
WO2012075140A1 (en) 2010-11-30 2012-06-07 Pharmasset, Inc. Compounds
US8889159B2 (en) 2011-11-29 2014-11-18 Gilead Pharmasset Llc Compositions and methods for treating hepatitis C virus
EP4005560A1 (en) 2013-08-27 2022-06-01 Gilead Pharmasset LLC Combination formulation of two antiviral compounds

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4808613A (en) 1986-11-21 1989-02-28 Bristol-Myers Company Rebeccamycin derivative containing pharmaceutical composition
GB8818430D0 (en) * 1988-08-03 1988-09-07 Tate & Lyle Plc Process
US5668271A (en) 1991-11-29 1997-09-16 Banyu Pharmaceutical Co., Ltd. Indolopyrrolocarbazole derivatives
US5437996A (en) 1992-11-24 1995-08-01 Banyu Pharmaceutical Co., Ltd. Microtetraspora strain for preparation of indolopyrrolocarbazole derivatives
US5591842A (en) 1991-11-29 1997-01-07 Banyu Pharmaceutical Co., Ltd. Indolopyrrolocarbazole derivatives
NZ245203A (en) 1991-11-29 1997-07-27 Banyu Pharma Co Ltd 5h-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6h)-dione derivatives substituted in position-13 by a pentose or hexose group; corresponding indolo-furano(anhydride)intermediates
US5589365A (en) 1991-11-29 1996-12-31 Banyu Pharmaceutical Co., Ltd. Process for producing glycosylated indolopyrrolocarbazole derivatives by culturing certain microorganisms
US5468872A (en) 1993-09-16 1995-11-21 Cephalon, Inc. K-252a functional derivatives potentiate neurotrophin-3 for the treatment of neurological disorders
CA2144940A1 (en) 1994-03-18 1995-09-19 Chikara Murakata Therapeutic agent for thrombocytopenia and indolocarbazole derivatives
US5804564A (en) 1994-05-09 1998-09-08 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyrrolocarbazole derivatives
US5922860A (en) * 1994-05-09 1999-07-13 Banyu Pharmaceutical Co., Ltd. Antitumor indolopyrrolocarbazole derivatives
FR2750135B1 (fr) * 1996-06-20 1998-08-14 Ceca Sa Acides fluoroalkyl glycosides uroniques et lactones-6(3) correspondantes, preparation et utilisations
IL127918A0 (en) 1996-08-22 1999-11-30 Bristol Myers Squibb Co Novel amino sugar and related sugar derivatives of indolylopyrrolocarbazoles their use as antitumor agents and pharmaceutical formulations
US6555677B2 (en) * 2000-10-31 2003-04-29 Merck & Co., Inc. Phase transfer catalyzed glycosidation of an indolocarbazole

Also Published As

Publication number Publication date
IL155543A0 (en) 2003-11-23
NO20031922D0 (no) 2003-04-29
WO2002036601A3 (en) 2002-11-28
AU2894502A (en) 2002-05-15
US20020058803A1 (en) 2002-05-16
WO2002036601A2 (en) 2002-05-10
US20040024196A1 (en) 2004-02-05
HUP0302923A2 (hu) 2003-12-29
IS6791A (is) 2003-04-16
BR0115036A (pt) 2004-02-25
PL365574A1 (en) 2005-01-10
KR100813086B1 (ko) 2008-03-17
BG107737A (bg) 2004-01-30
ZA200303198B (en) 2004-04-23
NO20031922L (no) 2003-06-27
HK1064053A1 (en) 2005-01-21
CZ20031209A3 (cs) 2003-10-15
EP1333826A2 (en) 2003-08-13
CN1482908A (zh) 2004-03-17
EA005209B1 (ru) 2004-12-30
NZ525398A (en) 2004-12-24
CN1240380C (zh) 2006-02-08
MXPA03003871A (es) 2003-07-28
JP3554560B2 (ja) 2004-08-18
US6555677B2 (en) 2003-04-29
AU2002228945B2 (en) 2006-02-02
HUP0302923A3 (en) 2005-02-28
CA2426815A1 (en) 2002-05-10
JP2004513131A (ja) 2004-04-30
KR20030082545A (ko) 2003-10-22

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Legal Events

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU