EA200000127A1 - Способ получения аминопроизводных алкилоксифуранона, получаемые этим способом соединения и применение этих соединений - Google Patents

Способ получения аминопроизводных алкилоксифуранона, получаемые этим способом соединения и применение этих соединений

Info

Publication number
EA200000127A1
EA200000127A1 EA200000127A EA200000127A EA200000127A1 EA 200000127 A1 EA200000127 A1 EA 200000127A1 EA 200000127 A EA200000127 A EA 200000127A EA 200000127 A EA200000127 A EA 200000127A EA 200000127 A1 EA200000127 A1 EA 200000127A1
Authority
EA
Eurasian Patent Office
Prior art keywords
compounds
alkyloxyfuranon
connection
formula
amino derivatives
Prior art date
Application number
EA200000127A
Other languages
English (en)
Other versions
EA002883B1 (ru
Inventor
Рафаэль Буше
Франсис Брион
Колетт Колладан
Жак Лагуарда
Original Assignee
Хехст Марион Руссель
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Хехст Марион Руссель filed Critical Хехст Марион Руссель
Publication of EA200000127A1 publication Critical patent/EA200000127A1/ru
Publication of EA002883B1 publication Critical patent/EA002883B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/60—Two oxygen atoms, e.g. succinic anhydride
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Предметом изобретения является новый способ получения соединений формулы (IV) или (I), исходя из рацемического алкилоксифуранона формулы (II), при этом Rи Rопределены в описании, новые соединения формулы (IV), а также промежуточные соединения этого способа и применение соединений формулы (IV) или (I) в способе синтеза соединений - ингибиторов фермента преобразования интерлейкина-1бета.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200000127A 1997-07-15 1998-07-09 Способ получения аминопроизводных алкилоксифуранона, получаемые этим способом соединения и применение этих соединений EA002883B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9708932A FR2766188B1 (fr) 1997-07-15 1997-07-15 Nouveau procede de preparation de derives amines d'alkyloxy furanone, composes issus de ce procede et utilisation de ces composes
PCT/FR1998/001480 WO1999003852A1 (fr) 1997-07-15 1998-07-09 Procede de preparation de derives amines d'alkyloxyfuranone, composes issus de ce procede et utilisation de ces composes

Publications (2)

Publication Number Publication Date
EA200000127A1 true EA200000127A1 (ru) 2000-08-28
EA002883B1 EA002883B1 (ru) 2002-10-31

Family

ID=9509210

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200000127A EA002883B1 (ru) 1997-07-15 1998-07-09 Способ получения аминопроизводных алкилоксифуранона, получаемые этим способом соединения и применение этих соединений

Country Status (34)

Country Link
US (1) US6235899B1 (ru)
EP (1) EP0998470B1 (ru)
JP (1) JP4450987B2 (ru)
KR (1) KR100519691B1 (ru)
CN (1) CN100363355C (ru)
AP (1) AP1071A (ru)
AR (1) AR015924A1 (ru)
AT (1) ATE239713T1 (ru)
AU (1) AU744272B2 (ru)
BG (1) BG64050B1 (ru)
BR (1) BR9810896A (ru)
CA (1) CA2296742C (ru)
CZ (1) CZ295312B6 (ru)
DE (1) DE69814395T2 (ru)
DK (1) DK0998470T3 (ru)
EA (1) EA002883B1 (ru)
EE (1) EE03873B1 (ru)
ES (1) ES2197489T3 (ru)
FR (1) FR2766188B1 (ru)
HR (1) HRP20000027B1 (ru)
HU (1) HU230148B1 (ru)
ID (1) ID23784A (ru)
IL (1) IL134031A (ru)
ME (1) ME01708B (ru)
NO (1) NO324508B1 (ru)
NZ (1) NZ502338A (ru)
PL (1) PL200820B1 (ru)
PT (1) PT998470E (ru)
RS (1) RS49832B (ru)
SK (1) SK284168B6 (ru)
TR (1) TR200000117T2 (ru)
UA (1) UA66364C2 (ru)
WO (1) WO1999003852A1 (ru)
ZA (1) ZA986203B (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7053056B2 (en) * 1998-07-02 2006-05-30 Idun Pharmaceuticals, Inc. C-terminal modified oxamyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
ATE472539T1 (de) * 2000-04-24 2010-07-15 Vertex Pharma Verfahren und zwischenprodukte zur herstellung von substituierten asparaginsäure-acetalen
PE20011350A1 (es) 2000-05-19 2002-01-15 Vertex Pharma PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE)
JP2003327568A (ja) * 2000-09-20 2003-11-19 Kanegafuchi Chem Ind Co Ltd 光学活性β−アミノ酸誘導体の製造方法
JPWO2002055478A1 (ja) * 2001-01-16 2004-05-13 鐘淵化学工業株式会社 光学活性アミノラクトン誘導体の製造法およびその中間体
NZ549665A (en) 2004-02-27 2010-09-30 Vertex Pharma Caspase inhibitors and uses thereof
HUE024556T2 (hu) 2004-03-12 2016-02-29 Vertex Pharma Eljárások és intermedierek aszparagin acetál kapszáz inhibitorok elõállítására

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6204261B1 (en) * 1995-12-20 2001-03-20 Vertex Pharmaceuticals Incorporated Inhibitors of interleukin-1β Converting enzyme inhibitors
US5716929A (en) * 1994-06-17 1998-02-10 Vertex Pharmaceuticals, Inc. Inhibitors of interleukin-1β converting enzyme

Also Published As

Publication number Publication date
DE69814395D1 (de) 2003-06-12
DE69814395T2 (de) 2003-12-11
ZA986203B (en) 1999-08-18
ATE239713T1 (de) 2003-05-15
EP0998470A1 (fr) 2000-05-10
ME01708B (me) 2008-08-07
US6235899B1 (en) 2001-05-22
SK302000A3 (en) 2000-11-07
ES2197489T3 (es) 2004-01-01
UA66364C2 (ru) 2004-05-17
CA2296742C (fr) 2009-12-08
AU8633398A (en) 1999-02-10
HUP0003857A3 (en) 2002-08-28
ID23784A (id) 2000-05-11
CZ200065A3 (cs) 2000-07-12
TR200000117T2 (tr) 2000-07-21
BG104073A (en) 2001-05-31
AP2000001732A0 (en) 2000-03-31
KR100519691B1 (ko) 2005-10-13
YU1500A (sh) 2002-10-18
AP1071A (en) 2002-05-20
FR2766188B1 (fr) 2000-02-11
KR20010021834A (ko) 2001-03-15
NO324508B1 (no) 2007-11-05
EE200000024A (et) 2000-10-16
JP4450987B2 (ja) 2010-04-14
BG64050B1 (bg) 2003-11-28
AR015924A1 (es) 2001-05-30
NO20000182D0 (no) 2000-01-14
AU744272B2 (en) 2002-02-21
IL134031A (en) 2004-06-01
CZ295312B6 (cs) 2005-07-13
EP0998470B1 (fr) 2003-05-07
HRP20000027A2 (en) 2000-10-31
NO20000182L (no) 2000-03-07
WO1999003852A1 (fr) 1999-01-28
HU230148B1 (hu) 2015-09-28
NZ502338A (en) 2001-09-28
PL200820B1 (pl) 2009-02-27
HUP0003857A2 (hu) 2001-04-28
DK0998470T3 (da) 2003-09-01
HRP20000027B1 (en) 2006-07-31
RS49832B (sr) 2008-08-07
BR9810896A (pt) 2000-09-26
SK284168B6 (sk) 2004-10-05
EE03873B1 (et) 2002-10-15
CN1269795A (zh) 2000-10-11
JP2001510191A (ja) 2001-07-31
PT998470E (pt) 2003-09-30
CA2296742A1 (fr) 1999-01-28
EA002883B1 (ru) 2002-10-31
PL338035A1 (en) 2000-09-25
CN100363355C (zh) 2008-01-23
FR2766188A1 (fr) 1999-01-22
IL134031A0 (en) 2001-04-30

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Legal Events

Date Code Title Description
PD4A Registration of transfer of a eurasian patent in accordance with the succession in title
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MK4A Patent expired

Designated state(s): RU